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Methyl B-12 Methyl B-12

Jarrow Formulas Methyl B12 is a dietary supplement in tasty lozenges with a biologically active form of vitamin B12 (methylcobalamin), which is the best assimilable form, as it does not have to be transformed in the organism.

The main biological function of vitamin B12 are: participating in carbohydrate, protein and fat metabolism, regulating erythropoiesis (the production of red blood cells) and affecting the normal functioning of the nervous system.

Methylcobalamin - methylated vitamin B12 (cobalamin) in the form of an active coenzyme; it takes part in homocysteine remethylation to methionine through methionine synthase. Disorders of homocysteine metabolism result in its accumulation in intracellular space and its subsequent export to the blood.

Regulation of homocysteine level
Depending on the degree of vitamin B12 deficiency, other deficiencies and genetic factors, impaired homocysteine remethylation may occur, leading to its slight, medium or serious increase in plasma. Hyperhomocysteinaemia in people is thought to be a risk factor of developing cardiovascular and neurodegenerative diseases, congenital malformations and cancer.

Synthesis of proteins and nucleic acids
Vitamin B12 participates in cell division. As methylcobalamin, it performs the function of a coenzyme needed to transform homocysteine into methionine. Methionine is an amino acid necessary for protein synthesis. It is also a donor of the methyl group after the activation of S-adenosyl methionine (SAM). SAM is a source of methyl group essential for the synthesis of phospholipids and neurotransmitters as well as DNA, RNA and protein methylation.

Erythropoiesis
There is a cause and effect relationship between vitamin B12 consumption and normal erythropoiesis in the organism. Together with folic acid, vitamin B12 is needed for the transformations of methyl groups involved in nucleotide synthesis.

Cobalamin deficiency leads to distorted DNA synthesis which, in turn, causes megaloblastic anaemia. The nuclei of erythropoietic precursor cells maturing in the bone marrow stay immature compared to those from cytoplasm. Such a cell is characterised by a larger average volume.

Role in energy production
Its role in metabolism stems from the fact that cobalamin is needed as a coenzyme in the form of deoxyadenosylcobalamin in the isomerisation of coenzyme A into succinyl-CoA, an intermediate in the cycle of citric acid, responsible for energy production during cellular respiration in the organism.

Brain and nervous system functions
Vitamin B12 plays a role in maintaining the normal functioning of the brain and the nervous system. Clinical studies have confirmed that its deficiency causes negative neurological effects, caused by demyelination in the spinal cord, the brain and the optic and peripheral nerves.

Moreover, its serious deficiencies lead to irreversible polyneuropathy - a syndrome of peripheral nerve damage whose clinical symptoms include autotopagnosia, taste, smell and sight disorders, irritability, memory losses, dementia and ataxia.

Reduction of the feeling of fatigue and tiredness
Researchers also state that there is a correlation between vitamin B12 consumption and the reduction of fatigue and tiredness. Insufficient cobalamin consumption and related anaemia symptoms contribute to the decrease of energy and exercise tolerance, as well as tiredness, dyspnoea and palpitation.

Recommended supplementation - for whom?
Vitamin B12 supplementation is particularly recommended for all people vulnerable to its deficiencies, that is: those who have problems with absorbing it, the elderly whose diet is not adjusted, people who are on a vegan diet, excessively drink alcohol or suffer from anorexia nervosa.

Vitamin B12 delivered with food is not very well absorbed, so supplementation is recommended, preferably in the biologically and metabolically active form. That is exactly methylcobalamin used in the product Jarrow Formulas Methyl B12 (!). 

Out Of Stock
Since 2005
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Methyl B-12 Methyl B-12 2500mcg 100 tab.
Jarrow Formulas
20.26 $

Methyl B-12 2500mcg 100 tab.

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Concentration:
Health:
Regeneration:

- Delivery even day after tomorrow

- Foreign shippment from 5.57 $ Every 81.03 $ reduces shipping costs by 2.70 $

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sales@mz-store.co.uk

01709231594 (mon.-fri 900-1700)

Description
  • Bioactive (methylated) form of vitamin B12
  • In the form of tasty lozenges
  • Large and effective dosage
  • Normal metabolism
  • Supports nervous system functions
  • Regulates the level of homocysteine
  • Maintains normal psychological functions
  • Participates in erythropoiesis
  • Supports the immune system
  • Reduces the feeling of fatigue and tiredness
  • Participates in the processes of cell division

Jarrow Formulas Methyl B12 is a dietary supplement in tasty lozenges with a biologically active form of vitamin B12 (methylcobalamin), which is the best assimilable form, as it does not have to be transformed in the organism.

The main biological function of vitamin B12 are: participating in carbohydrate, protein and fat metabolism, regulating erythropoiesis (the production of red blood cells) and affecting the normal functioning of the nervous system.

Methylcobalamin - methylated vitamin B12 (cobalamin) in the form of an active coenzyme; it takes part in homocysteine remethylation to methionine through methionine synthase. Disorders of homocysteine metabolism result in its accumulation in intracellular space and its subsequent export to the blood.

Regulation of homocysteine level
Depending on the degree of vitamin B12 deficiency, other deficiencies and genetic factors, impaired homocysteine remethylation may occur, leading to its slight, medium or serious increase in plasma. Hyperhomocysteinaemia in people is thought to be a risk factor of developing cardiovascular and neurodegenerative diseases, congenital malformations and cancer.

Synthesis of proteins and nucleic acids
Vitamin B12 participates in cell division. As methylcobalamin, it performs the function of a coenzyme needed to transform homocysteine into methionine. Methionine is an amino acid necessary for protein synthesis. It is also a donor of the methyl group after the activation of S-adenosyl methionine (SAM). SAM is a source of methyl group essential for the synthesis of phospholipids and neurotransmitters as well as DNA, RNA and protein methylation.

Erythropoiesis
There is a cause and effect relationship between vitamin B12 consumption and normal erythropoiesis in the organism. Together with folic acid, vitamin B12 is needed for the transformations of methyl groups involved in nucleotide synthesis.

Cobalamin deficiency leads to distorted DNA synthesis which, in turn, causes megaloblastic anaemia. The nuclei of erythropoietic precursor cells maturing in the bone marrow stay immature compared to those from cytoplasm. Such a cell is characterised by a larger average volume.

Role in energy production
Its role in metabolism stems from the fact that cobalamin is needed as a coenzyme in the form of deoxyadenosylcobalamin in the isomerisation of coenzyme A into succinyl-CoA, an intermediate in the cycle of citric acid, responsible for energy production during cellular respiration in the organism.

Brain and nervous system functions
Vitamin B12 plays a role in maintaining the normal functioning of the brain and the nervous system. Clinical studies have confirmed that its deficiency causes negative neurological effects, caused by demyelination in the spinal cord, the brain and the optic and peripheral nerves.

Moreover, its serious deficiencies lead to irreversible polyneuropathy - a syndrome of peripheral nerve damage whose clinical symptoms include autotopagnosia, taste, smell and sight disorders, irritability, memory losses, dementia and ataxia.

Reduction of the feeling of fatigue and tiredness
Researchers also state that there is a correlation between vitamin B12 consumption and the reduction of fatigue and tiredness. Insufficient cobalamin consumption and related anaemia symptoms contribute to the decrease of energy and exercise tolerance, as well as tiredness, dyspnoea and palpitation.

Recommended supplementation - for whom?
Vitamin B12 supplementation is particularly recommended for all people vulnerable to its deficiencies, that is: those who have problems with absorbing it, the elderly whose diet is not adjusted, people who are on a vegan diet, excessively drink alcohol or suffer from anorexia nervosa.

Vitamin B12 delivered with food is not very well absorbed, so supplementation is recommended, preferably in the biologically and metabolically active form. That is exactly methylcobalamin used in the product Jarrow Formulas Methyl B12 (!). 

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Composition

Composition

Container size: 100 lozengesServing size: 1 lozengeServings per container: 100
per 1 lozengeamount%DV
Vitamin B-12 (as Methylcobalamin)2,500 mcg104,170%

Other ingrednients

Xylitol, cellulose, stearic acid (vegetable source), natural flavor, magnesium stearate (vegetable source), citric acid and silicon dioxide.

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Methylcobalamin

Information

What is methylcobalamin?

Methylcobalamin is a biologically active form of vitamin B12. It is one of the two forms of this vitamin that may be used as cofactors in various reactions. It differs from popular cyanocobalamin in the presence of methyl group instead of cyanide, thanks to which it releases the organism from the need of neutralizing this harmful factor.

The methyl group from methylcobalamin may be transferred to homocysteine, thanks to which it comes back in the form of methionine in order to be further converted to SAMe, which is the main donor of methyl groups in our organism. These methyl groups may be then used in the processes of creatine production, in neurotransmitter metabolism and as DNA methylation, thanks to which we achieve proper energy level, better well-being and generally better condition of the organism. B12 is a coenzyme for three enzymes: isomerase, methyltransferase and dehalogenase.

Apart from the influence on the nervous system, the supply of vitamin B12 is also very important for the proper synthesis of red cells as well as hemoglobin and anemia prevention.

 

Methylcobalamin in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.

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