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|Servings: 1mg 60 lozenges|
Life Extension Methylcobalamin is a dietary supplement containing 1mg of vitamin B12 in one lozenge in the form of methylocobalamin. This sort of cobalamin may be a cofactor of enzymatic reactions, while other vitamin B12 forms has to be reshaped in order to play a similar role. Its main biological functions are: participation in carbohydrates, proteins and fats metabolism, regulation of red cells production and influence on proper nerve system functioning.
The main method of leveling serious deficits of vitamin B12 in the organism is intramuscular injection. The problem with administering cobalamin orally is that it cannot be converted in the proper methylocobalamin amounts, required by the organism to level deficits and counteract their effects.
The easiest way to circumvent this problem is missing the liver. Taking methylocobalamin in the form of sublingual lozenges enables the substance to be transmitted directly to the bloodstream. It has been proven that such a way of its administration in comparison to the classic form is characterized by fivefold higher absorption.
Vitamin B12 (cobalamin) is the most chemically complexed vitamin and, at the same time, the most beautiful. Its amazing look can be owed to rich, ruby red taint of crystals, in the form of which it appears. It was discovered as the last vitamin from B group and its chemical properties and the spectrum of potential impact on the human organism deserve special attention.
Vitamin B12 helps in the proper production of red cells
Cobalamin is essential in the treatment of Thiamine Responsive Megaloblastic Anemia (malignant), caused by this vitamin deficits. As a result of this, we face inappropriate DNA synthesis, which entails the dysfunction of blood cells maturation in bone marrow. We observe then the decrease of the general erythrocytes number in blood and the appearance of huge cells supersaturated with hemoglobin.
Insufficient supply of vitamin B12 may appear among people using poorly balanced vegan diets, too little varied diets, overusing alcohol or suffering diseases causing low bowel absorption. Also, the lack or insufficient amount of the factor responsible for this vitamin absorption (Castle factor) may lead to deficits. This may appear among people after stomach resection and may diminish with age.
Homocysteine level regulation
The research show, that vitamin B12 may play an important role in protein synthesis, responsible for the cardiovascular system health. Deficits of cobalamin lead to the decreased production of the methionine synthase enzyme, which plays a crucial role in the conversion of homocysteine amino acid to methionine. The effect of this may be hyperhomocysteinemia, which is thought to be and independent risk factor of the development of cardiovascular and neurodegenerative diseases as well as fetal malformation and cancers.
The influence on the nervous system
It is believed that neurological effects of vitamin B12 deficiency may appear even in case of the absence of anemia, especially above the age of 60. Excessively low level of cobalamin mainly influences peripheral nerves and in the subsequent stages it may also affect the spinal cord, which may result in mental functions disorders. Frequently the first symptoms are “slower thinking”, confusion and memory loss. Even the levels only slightly below the optimal may lead to nervous system damages.
Moreover, it is known that the substantial number of cognitive and emotional abilities depends on the optimal level of vitamin B12. Among elderly people, subjected to cognitive tests, low scores were correlated to low cobalamin concentration in blood. It is worth mentioning that people with diagnosed depression have low plasma cobalt concentration, a mineral which constitutes a central part of vitamin B12.
Fatigue and weariness reduction
The researchers also show that there is a relationship between vitamin B12 intake and decreased exhaustion and weariness. Insufficient cobalamin intake and related anemia symptoms contribute to decreased energy and effort tolerance, fatigue, dyspnea and palpitations.
In relation to the fact that low toxicity and high safety of usage even in large doses were proven, the supplement can be used for a long period of time. According to the recent data, the supplementation of 2mg per day is recommended in case of the deficit syndromes appearance, such as increased homocysteine level and neurological problems.
Summing up, Life Extension Methylcobalamin is a product addressed to all the people exposed to vitamin B12 deficiencies, to which we may qualify: the people with absorption disorders, elderly people and the people who do not eat properly, use vegan diet, overuse alcohol or suffer anorexia nervosa.
Cobalamin delivered with food is not absorbed best, therefore its supplementation is recommended, preferably in the biologically and metabolically active form. Such a form may be found in methylocobalamin contained in the preparation Life Extension Methylcobalamin.
Vitamin B12 is good for mental health - it improves mood and increases resistance to stress. Deficiencies of this vitamin are very common - it is estimated that only ten percent of the population has proper levels. Due to the fact that it naturally occurs mainly in animal products, its supplementation is a must for vegetarians and vegans, but considering all the health promoting properties of vitamin B12 it should be taken by everyone. When planning supplementation take into consideration both your dose, as well as its form, because the absorption of vitamin B12 is a complicated process. I recommend vitamin B12 in the form of methylated (i.e., methylcobalamin) Vitamin B12 is difficult to overdose. It dissolves in water and is rapidly cleared from the body. You should know that the absorption of vitamin B12 very improves contained in the popular spice - black pepper, piperine. Vitamin B12 should also be combined with calcium, which improves its absorption. If you take vitamin C, be sure to keep an hour break between Vitamin C and vitamin B12. Vitamin C weakens the absorption of B12.
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|per 1 lozenge||amount||%DV|
|Vitamin B12 (as methylcobalamin)||1 mg||-|
xylitol, sorbitol, maltodextrin, stearic acid, vegetable stearate, microcrystalline cellulose, natural vanilla flavor, rice starch, modified food starch.
What is methylcobalamin?
Methylcobalamin is a biologically active form of vitamin B12. It is one of the two forms of this vitamin that may be used as cofactors in various reactions. It differs from popular cyanocobalamin in the presence of methyl group instead of cyanide, thanks to which it releases the organism from the need of neutralizing this harmful factor.
The methyl group from methylcobalamin may be transferred to homocysteine, thanks to which it comes back in the form of methionine in order to be further converted to SAMe, which is the main donor of methyl groups in our organism. These methyl groups may be then used in the processes of creatine production, in neurotransmitter metabolism and as DNA methylation, thanks to which we achieve proper energy level, better well-being and generally better condition of the organism. B12 is a coenzyme for three enzymes: isomerase, methyltransferase and dehalogenase.
Apart from the influence on the nervous system, the supply of vitamin B12 is also very important for the proper synthesis of red cells as well as hemoglobin and anemia prevention.
Methylcobalamin in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
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