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Thanks to combining two the most bioavailable forms of vitamin B12 in the appropriate dose, the product becomes a great means to level up severe deficiency caused by improperly balanced diet. Active forms may be immediately utilized by the organism and do not undergo complicated transformations, as in the case of a synthetic and incredibly popular form of vitamin B12 – cyanocobalamin. For this reason, the product is recommended to people with MTHFR gene impairment disenabling the production of MTHFR enzyme, essential for the proper metabolism of vitamin B12.
Vitamin B12 – is and organic chemical compound soluble in water, containing central atom in the form of cobalt. It abundantly appears in foods of animal origin, therefore especially vegetarians are prone to deep deficiencies of this valuable element. It takes part in cell divisions, erythrocyte production and fatty acid breakdown.
Vitamin B12 demonstrates high blood-forming activity. It takes part in the production of red cells in bone marrow, therefore its deficiency leads to the development of anemia.
The most dangerous complication related to vitamin B12 deficiency is the so-called malignant anemia, which is characterized by the inability of the organism to absorb this vitamin from the digestive system. Immature cells, called megaloblasts are released to the bloodstream. Malignant anemia is a kind of autoimmune disease, as a result of which the immune system emits antibodies attacking IF factor, essential to absorb vitamin B12 through stomach mucosa.
Vitamin B12 and methylation
Vitamin B12 plays a very important function of a cofactor in methylation processes in the whole organism. It is primarily responsible for proper conversion of homocysteine to methionine. Methylation disorders lead to the increased homocysteine level in the plasma, which results in the increased risk of developing atherosclerosis, stroke, heart attack and other disorders in the cardiovascular system.
Regulation of the nervous system
Vitamin B12 is responsible for the synthesis of nucleotides and choline, which are in the composition of myelin sheath, protecting neurons and ensuring communication. Therefore, one of the symptoms of vitamin B12 deficiency from the side of the nervous system which is the most difficult to recognize are balance disorders, limb numbness and the feeling of tingling.
Cobalamin takes part in the synthesis of serotonin – one of the most important neurotransmitters protecting from depression, bad mood and irritation.
Elderly people are the most prone to serotonin deficiency, among whom we observe decreased secretion of stomach juice, essential for the absorption of vitamin B12 and subsequent neurotransmitter synthesis. Starting supplementation in this case results in energy growth, boost of concentration, memory and mental ability.
Vitamin B12 takes part in the processes of transforming proteins, carbohydrates and fats, which conditions proper energy metabolism of the organism. By the same token, it decreases fatigue, adds energy and vital powers.
Proper concentration of vitamin B12 in blood conditions long, steady and efficient sleep – cobalamin supports the production of a very important hormone, melatonin, which by its antagonist activity towards cortisol level allows to fall deeply asleep.
Summing up, Active B12 is an ideal product to supplement vitamin B12 deficiency in the organism. Thanks to its active forms, it is especially recommended to people with methylation problems and vegetarians. Large dose of the product also works well in case of anemia.
The dose of 1000 mg per day is sufficient to cover basic needs for this vitamin. The doses above the recommended amount should be considered by vegans and elderly people.
In order to increase the absorption of vitamin B12, it is recommended to take the supplement with calcium.
In case of additional supplementation with vitamin C, it is recommended to take a few hour break between taking these two vitamins.
Seeking Health is a brand which makes sure that the products it produces are characterized by high quality and purity, therefore the majority of their products is free from magnesium stearate, allergens and GMO.
This brand is directed at fighting the causes and not the symptoms, therefore the aim of the company is primarily to help in ensuring optimal work of the digestive system, among others by launching on the market high-class products supporting digestion and regenerating and nourishing the intestines, which consequently improves bioavailability of the substances beneficial to health and increases organism’s resistance to the effect of toxins coming from external environment.
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What is methylcobalamin?
Methylcobalamin is a biologically active form of vitamin B12. It is one of the two forms of this vitamin that may be used as cofactors in various reactions. It differs from popular cyanocobalamin in the presence of methyl group instead of cyanide, thanks to which it releases the organism from the need of neutralizing this harmful factor.
The methyl group from methylcobalamin may be transferred to homocysteine, thanks to which it comes back in the form of methionine in order to be further converted to SAMe, which is the main donor of methyl groups in our organism. These methyl groups may be then used in the processes of creatine production, in neurotransmitter metabolism and as DNA methylation, thanks to which we achieve proper energy level, better well-being and generally better condition of the organism. B12 is a coenzyme for three enzymes: isomerase, methyltransferase and dehalogenase.
Apart from the influence on the nervous system, the supply of vitamin B12 is also very important for the proper synthesis of red cells as well as hemoglobin and anemia prevention.
Methylcobalamin in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
Adenosylcobalamin - a biologically active form of vitamin B12, which similarly to its methylated form does not need to undergo additional biochemical transformations in order to enter metabolic pathways in the human organism.
Apart from the best assimilability, adenosylcobalamin is distinguished from other forms of vitamin B12 by its high affinity for regeneration of nervous tissue. It is indicated that this form of cobalamin is engaged in the production of myelin sheaths with key meaning for proper neurotransmission. Apart from this, vitamin B12 is conducive to maintaining optimal functionality of the nervous system, being conducive to the synthesis of neurotransmitters.
Vitamin B12 is also an incredibly important regulator of methylation process, thanks to which its supplementation positively influences metabolism of the whole organism. It is a coenzyme in the conversion reactions of homocysteine to methionine as well as methylmalonyl-CoA to succinyl-CoA. Because of the first reaction, proper supply of vitamin B12 is also conducive to maintaining high concentrations of S-adenosylmethionine, thanks to which it positively influences mental functions.
Moreover, vitamin B12 is a key regulatory factor, taking part in erythropoiesis, i.e. the process of forming red cells. Its improper supply may be the cause of the development of the so-called vitamin B12 deficiency anemia.
Supplementation with vitamin B12 should be considered especially be people on vegetable diets and those who take drugs from the group of proton-pump inhibitors (PPIs) and metformin.
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