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Swanson Folian Quatrefolic is a dietary supplement containing a carefully selected dose of easily available 4th generation folate – Quatrefolic®, in the form of the (6S)-5-methyltetrahydrofolic acid glucosamine salt.
Quatrefolic® is the glucosamine salt of (6S) -5-methyltetrahydrofolate (5-MTHF), which is structurally similar to the reduced and active form of folic acid. This patented ingredient is the 4th generation folate with high stability, very good solubility in water, improved bioavailability with the thoroughly-tested safety of use.
Unlike folic acid, which is a synthetic version of folate, 5-MTHF occurs naturally in food. It is believed that folate deficiency is one of the most common vitamin deficiencies in the world. The reason for this is mainly food processing, inadequate selection of the products consumed and intestinal disorders. In a human body, 5-MTHF can be transformed into any other form of active folate.
Folates are involved in the formation of purines and pyrimidines, which in turn are needed for the synthesis of DNA and RNA nucleic acids. This is particularly important during fetal development during the first trimester of pregnancy. In addition, they are responsible for heme biosynthesis, formation and development of red and white blood cells, as well as amino acid conversion, including glycine to serine, methionine to homocysteine, phenylalanine from tyrosine and glutamine acid from histidine.
Hyperhomocysteinemia is widely regarded as an independent risk factor for peripheral, coronary and cerebral vessel diseases. Molecular mechanisms of homocysteine-induced cellular dysfunction include an increased expression of inflammatory cytokines, altered bioavailability of nitric oxide, induction of oxidative stress, activation of apoptosis, and defective methylation. Reduction of elevated plasma homocysteine levels means lowering of occurrence of not only an independent risk factor for cardiovascular disease, neural tube defects or congenital defects, male and female fertility decrease but also Alzheimer's disease, cognitive impairment, osteoporosis, rheumatoid arthritis, kidney failure, and tumors.
Supplementation of 5-MTHF is more beneficial than administration of folic acid. 5-MTHF is immediately available to react with homocysteine, thus reducing the chance of developing hyperhomocysteinemia. The folate coenzymes in combination with vitamin B12 enable the conversion of the homocysteine amino acid to methionine.
The conversion of the tetrahydrofolic acid to 5-methyltetrahydrofolate takes place via the methylenetetrahydrofolate reductase enzyme. In people with a genetic disorder of this enzyme, the transformations of folates are impaired, predisposing them to an increased risk of the above-mentioned health problems. For both reasons, it is recommended to supplement the active form of folates in the form of the (6S)-5-methyltetrahydrofolic acid glucosamine salt contained in Swanson Folian Quatrefolic.
Depression, cognitive impairment, dementia and Alzheimer's disease
Research suggests that there is a connection between mental vitality, dementia, Alzheimer's disease, and the number of folates in the brain. In addition, there is a direct relationship between the amount of this component in plasma and depression. It has been noticed that the level of folate in the cerebrospinal fluid decreases with age and that there is a correlation of this phenomenon with a mental activity, especially with depression and dementia. Folate deficiency may contribute to a depressed mood, which is why folate supplementation may be useful in patients with depression.
Folates are used to treat megaloblastic anemia, which is characterized by deformation and a larger size of red blood cells, as well as a slower rate of their production and a shorter lifespan. This type of anemia is most common among infants, adolescents, pregnant and breastfeeding women, alcoholics, the elderly and those who suffer from malnutrition of nutrients.
The demand for folate increases during the increased growth of human cells, e.g. during pregnancy. The period before and right after the fertilization is particularly important when it comes to folate supplementation because it is when a woman often does not know that she is pregnant. It is recommended that the level of folic acid is high for at least a month before possible fertilization and remain at this level for the first three months of pregnancy. Studies have shown that a low folate intake increases the risk of poor fetal or placenta growth and the birth of a child with congenital defects, in particular of the neural tube, such as spina bifida or brain defect.
Infants and children
Foliates are especially important nutrient when the growth of human cells is very active, so their deficiency can slow down the overall development of the body. Infants, children and adolescents are in a critical growth phase, and an appropriate level of folate is recommended to prevent various diseases, such as anemia, and to allow their proper development.
Aging of the body causes many physiological changes. Several studies have focused on understanding how these transformations may affect the nutritional requirements of adults and the elderly people, as well as how diet and nutrition may affect or modify these changing functions. Study results indicate that the occurrence of heart disease can be controlled with nutritional ingredients.
Recent studies show that hyperhomocysteinemia, just as in case of high levels of LDL cholesterol in the blood, is a factor that contributes to the risk of coronary disease. The level of homocysteine in the blood is largely controlled by vitamin B12, vitamin B6, and folate. In addition, epidemiological studies and case studies suggest that low concentrations of folate in the blood are associated with an impairment of cognitive functions, dementia and Alzheimer's disease. It was hypothesized that there is a connection between folate deficiency and cognitive impairment, which most probably results from the lack of active folates potent to reduce homocysteine levels and their impact on the vascular system.
In conclusion, Swanson Folian Quatrefolic is a dietary supplement, whose intake is recommended primarily to women before and during the early stages of pregnancy, as well as in the treatment of anemia caused by folate deficiency. The product is also recommended for people with genetic load or predisposed to an increased risk of cardiovascular disease.
Many drugs reduce body’s ability to use folates properly. These include: aspirin, cholesterol-lowering drugs, oral contraceptive pills, gastric acid neutralizers, as well as ametopterin, a known cytostatic drug used in cancer therapy and rheumatoid arthritis. When taking these drugs (and many others) the recommended dose of folates is 800-1,000 mcg per day, preferably in the form of 5-MTHF. When taking folates, it is recommended to take an appropriate amount of vitamin B12 in the form of methylcobalamin.
SWANSON is a well known company operating since 1969, which offers a wide selection of diet and nutritional supplements. Among their products are antioxidants, amino acid supplements, products improving immunity, probiotics, minerals and vitamins. At SWANSON you can also purchase of supplements enhancing your cardiovascular stamina, urinary, nervous and digestive systems. The offer includes products designed specifically for women or men, as well as supplements helping to loose weight.
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Brown rice flour, capsule shell: hydroxypropylmethylcellulose, anti-caking agents: fatty acids magnesium salts and silicon dioxide.
Vitamin B9 (folic acid, folacin, vitamin M) is part of a complex of B vitamins soluble in water. It takes part in the production of red blood cells, in cooperation with vitamin B12, preventing anaemia progression, its molecules are involved in catalysis of hematopoietic processes. Together with vitamins B6 and B12 it helps in the treatment of hyperhomocysteinemia. It eliminates disturbances in the gastrointestinal tract. It affects the proper functioning of the immune system. Necessary during pregnancy, because its deficiency causes neural tube defects in the fetus. The natural ingredient of yeast, eggs, liver, green vegetables and it is synthesized in the gastrointestinal tract by intestinal bacteria.
Dosage: The daily requirement is 0.1-0.2 mg.
Quatrefolic is the glucosamine salt of (6S)-5-methyltetrahydrofolate and also an active form of folic acid. It is an innovative nutrient (fourth generation folate) which is well soluble in water and thus absorbed effectively by the body. As an organic compound ranked among B vitamins, it is necessary for normal functioning at the cellular level.
Adding folates to a diet is recommended especially to pregnant and lactating women. These compounds may contribute to healthy foetal development. According to studies, their intake may reduce the incidence of pregnancy complications.
Some sources report that folate supplementation supports cardiovascular function (blood production) and contribute to healthy immune function.
Quatrefolic may affect the metabolism of homocysteine whose levels increase in the body over time. Adding it to a diet may thus prevent the development of dementia and maintain healthy cognitive functions which is vital to adults, especially the elderly.
What is 5-methyltetrahydrofolate (5-MTHF)?
5-methyltetrahydrofolate (5-MTHF) is a methylated, biologically active form of folate. It is especially willingly used by people with folic acid metabolism disorders, especially by polymorphisms of the gene coding the production of methyltetrahydrofolate reductase. Using this form allows to skip narrow gorge created by this polymorphism and enjoy all effects induced by folates. It is also a good substitute for synthetic folic acid (pteroylmonoglutamic acid), which in clinical trials demonstrates the ability to increase the frequency of developing cancers.
Folates, also called vitamin B9 have a wide contribution to the development of the nervous system. They contribute to converting homocysteine to methionine and then to s-Adenosyl methionine, which is the main donor of methyl groups. Thanks to this, the condition of the circulatory system is increased, as the amount of pro-inflammatory homocysteine is decreased and the intensity of the production processes of creatine and neurotransmitter synthesis is higher, which is reflected in the reduction of fatigue and better psychological condition.
5-MTHF in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
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