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This supplement balances the level of group B vitamins in an excellent way and prevents form potential deficiencies. Because of the presence of vitamin B12 active forms and folic acid it is suitable for people with methylation disorders (e.g. as a result of MTHFR gene mutation) or increased homocysteine level.
Why methyl forms?
When using a multiwitamin formulation it is worth checking if the contained in the composition compounds are in such a form, which will allow for their unproblematic use according to the organism’s needs. The biggest problem concerns folic acid and vitamin B12. Vast majority of available on market supplements is based on their synthetic forms which are not suitable for everyone.
Scientists estimate that every fourth person is struggling with the problem of MTHFR gene polymorphism, often without even realizing it. This gene has a very important task in the organism - it codes the enzyme responsible for homocysteine metabolism. This defect closely correlates with folate deficiency because it prevents the transformation of biologically inactive folic acid to the active form of folates. So supplementation with regular folic acid in such people will be purposeless and will not bring any effects.
Similar is the case of vitamin B12. The cyanocobalamin available in most supplements, in order to be absorbed by the organism, has to go through a series of complicated processes. People with mutation of the MTHFR gene will not be able to properly metabolize it, which will further worsen health problems and methylation disorders. The solution to this is supplementation with an active, methylated form, exactly the same is put in the presented supplement.
Vitamin B1 (thiamine) – influences the work of the nervous, cardiovascular and muscular systems. The organism needs it to convert the carbohydrates supplied with food to glucose, which is the preferred source of energy. Moreover, it supports the breakdown of proteins and fats. Thiamine is also used by the nervous system. This vitamin is involved in the synthesis of GABA – a neurotransmitter responsible for mental well-being. In addition, it helps in the creation of myelin sheaths that surround the neurons, protecting them from damage.
Vitamin B2 (riboflavin) – similarly to the abovementioned thiamine mentioned it is involved in the conversion of carbohydrates into the energy necessary for life. What is more, it prevents diseases of the cardiovascular system – it cooperates with folates to reduce the level of homocysteine. In addition, it helps to reduce the high blood pressure. High doses of this vitamin are used in the treatment of migraine pain and anemia. They also have a beneficial influence on bone density and reduce the risk of bone fractures.
Vitamin B3 (niacin) – supports the health of the cardiovascular system and inhibits the intensity of inflammation. It is an excellent regulator of the lipid panel, it allows to lower the level of LDL cholesterol and triglycerides, and at the same time promotes an increase in the level of the beneficial HDL fraction. In the context of niacin, longevity is often mentioned. Researchers believe that as a precursor to NAD + it can slow down the aging process of the organism and increase its psychophysical efficiency. It is also often used to improve the condition of hair and skin.
Vitamin B4 (choline) – as a matter of fact, it is a vitamin-derived substance, although due to its functions and importance for the nervous system, it has long been included in the vitamin B group. It is still referred to as vitamin B4. It is essential for the construction of myelin, which determines mental abilities and proper motor coordination. In addition, it takes part in the synthesis of acetylcholine, which memory and other cognitive functions depend on. Choline deficiency is especially dangerous for pregnant women, as it can impair fetal development.
Vitamin B5 (pantothenic acid) – helps to convert food into energy and improves the process of using proteins and fats. It acts as a precursor of coenzyme A, which activates a very large group of enzymes. It is also necessary for the production of adrenocortical hormones and promotes the correct response of the organism to stress. Moreover, it helps to maintain normal skin condition and prevents hair loss.
Vitamin B6 (pyridoxine) – promotes protein metabolism, reduces the intensity of inflammation in the organism and participates in the synthesis of key neurotransmitters. What is more, it is essential for the proper functioning of the DAO enzyme, which is responsible for the breakdown of histamine. Therefore, supplementation can be beneficial for people with intolerance or hypersensitivity to histamine. Low levels of vitamin B6 correlate with high levels of homocysteine, therefore people with homocysteine disorders must take into account not only the supply of adequate amounts of vitamin B12 and folic acid, but also vitamin B6.
Vitamin B7 (biotin) – similarly to other group B vitamins, it affects the conversion of proteins, fats and carbohydrates. It is important for maintaining the proper function of the nervous system, it helps to improve the condition of the skin and hair. Moreover, it is essential for the production of myelin sheath that surrounds the nerves and facilitates the transmission of nerve impulses. Biotin deficiency is associated with reduced antibody synthesis and increased breakdown of T lymphocytes, which can impair the function of the immune system.
Vitamin B8 (inositol) – is a chemical compound that belongs to sugar alcohols, and because it can be synthesized in the organism it technically does not meet the requirements to be a vitamin. Like choline, it is a precursor to phospholipids that are part of cell membranes. In supplementation, it is often used in the treatment of PCOS (polycystic ovarian syndrome) and accompanying metabolic disorders. In addition, it positively affects mental well-being, reduces depressive-anxiety symptoms and reduces the frequency of panic attacks.
Vitamin B9 (folic acid) – in the presented supplement it appears as Quatrefolic®, or glucosamine salt of (6S)-5-methyltetrahydrofolic acid. It is a natural form of folate, which is characterized by the highest bioavailability and can be directly used in the organism. This compound is essential for pregnant women – supports fetal development, prevents neural tube defects, reduces the risk of perinatal complications. Additionally, it participates in the synthesis of the most important neurotransmitters. Finally, it conditions the proper metabolism of homocysteine, which is crucial for the health of the cardiovascular system.
Vitamin B10 (PABA acid) – it is a compound from the group of non-protein amino acids. It is commonly called a vitamin, although technically it should be classified as a vitamin-derived substance. It is an essential component of THF, i.e. tetrahydrofolic acid, which is involved in the methylation process and influences the transformation of homocysteine to methionine. It is also necessary for the organism to properly absorb vitamin B5. Moreover, it has a great ability to protect against the harmful effects of sunlight.
Vitamin B12 (cobalamin) – in the presented supplement as methylcobalamin, the most bioavailable form of this vitamin. It is responsible for the proper course of methylation processes. It acts as a cofactor of methionine synthase, which catalyzes the conversion of homocysteine to methionine. Additionally, it participates in the production of red blood cells. It also affects the functions of the nervous system and the synthesis of key neurotransmitters.
To sum up, Aliness Vitamin B Complex B-15 Methyl is a highly effective supplement which contains group B vitamins in the forms that can be directly used by the organism. It is recommended especially for people with elevated homocysteine level which indicates to disorders in methylation processes. It will have a great effect in people diagnosed with MTHFR gene polymorphism.
The supplement contains 11 vitamins from group B. Appropriately large doses and bioactive forms make 1 capsule a day enough to achieve the desired effects. Specialists suggest that you take group B vitamins in the first half of the day. Taken in the evening can make it difficult to fall asleep.
Even though group B vitamins dissolve in water, due to the presence of niacin, one should not take the supplement on an empty stomach. Supplementation during a meal reduces the risk of so-called vascular blush (severe redness of the skin, burning and tingling sensation). The so-called flushing quickly subsides and does not threaten health, however, it is usually quite unpleasant, and the intense red coloring of the face in some people causes embarrassment.
Aliness is a Polish brand owned by Medicaline. The company has advanced development and research facilities and meets the demanding European Standards of Production and Storage based on the pharmaceutical standard GMP and HACCP. A team of experienced specialists supervises the quality of manufactured dietary supplements. The company uses only the highest quality certified raw materials, often occurring in patented forms.
Aliness cooperates with the research laboratories accredited by the Main Pharmaceutical Inspectorate - SGS Poland and J.S. Hamilton Poland S.A., and also with the National Institute of Medicines, responsible for quality and safety control in research and development. Many Aliness products have an ecological certificate, which is a guarantee of the lack of use of artificial fertilizers, pesticides and chemical plant protection products at all stages of the production of the raw material.
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|per 1 capsule||amount||%DV|
|Vitamin B5 (Pantothenic acid) (as D-Calcium Pantothenate)||15 mg||250%|
|Vitamin B1 (Thiamine) (as Thiamine HCL)||15 mg||1364%|
|Vitamin B2 (Riboflavin)||15 mg||1071%|
|Vitamin B6 (as Pyridoxal-5-Phosphate)||15 mg||1071%|
|Vitamin B3 (Niacin) (as Nicotinic acid)||15 mg||94%|
|Para-Aminobenzoic Acid (PABA)||15 mg||**|
|Quatrefolic® (6S)-5-methyltetrahydrofolic acid glucosamine salt||232 µg||60%|
|- of which folate||120 µg|
|Vitamin B12 (Metylokobalamina)||15 µg||600%|
Microcrystalline cellulose, glazing agent: hydroxypropyl methylcellulose.
Choline belongs to the soluble in liquids group of B vitamins. It is an organic nitrogen base containing lecithin, and acetylcholine. Together with inositol is involved in the metabolism of fats and cholesterol metabolism, preventing its accumulation on the walls of arteries and deposits in the gallbladder. With the penetration of the brain, contained lecithin improves its action and improves memory. Used in the treatment of age-related diseases (Alzheimer's). It occurs in plant foods: yeast, wheat germ, lecithin, green leafy vegetables and egg yolks.
Vitamin B5 (calcium pantothenate, pantothenic acid, pantotenol) is part of a complex of B vitamins affects the development of the central nervous system, is the building substance of cells. In the body synthesized by the intestinal bacteria. It occurs in animal products (meat, kidneys, liver) and plants (wheat germ, wheat bran, nuts, grains, green vegetables). Prevents fatigue and excessive stress, accelerates the healing of cuts and wounds, acts as a stimulant for the side effects of the use of antibiotics. Deficiency causes skin changes, and difficulty in blood clotting.
Calcium (element chem. symbol Ca, atomic no. 20, the group of alkaline earth metals) is the basic building substance of bones and teeth, in which stored is 99% of the element, in the form of hydroxylapatite. When building bones and teeth, phosphorus is very important in the right proportion. It is a base-forming element and activator of many enzymes (ATPase) necessary to release the energy of ATP. It has a significant effect on blood clotting and regulates blood pressure and neuromuscular conductivity. Thanks to the reduced permeability of cell membranes, it soothes the symptoms of food allergies. Calcium is actively involved in the metabolism of iron interacts with vitamins A, C and D and phosphorus, magnesium. Natural source of calcium are animal products (dairy products, sardines, salmon, sprats eaten with bones) and plant products (nuts, soybeans, sunflower seeds). Absorption takes place in the small intestine (less in the colon), it has an effect on the level of lactose, insoluble fibre, organic acids, alkalinity (low pH). The best absorption have organic compounds (lactates, amino acid chelates etc.). Obstructing the absorption of calcium is caused by: phytic acid and oxalic acid as well as excess fat. Scientific studies have confirmed that the combination of calcium, magnesium, boron and vitamin D in dose 3 mg / 24h effectively prevent osteoporosis. Supplements on the market are both mono-preparation supplements (enriched with vitamin D3) and multi-component supplements, available at www.muscle-zone.pl.
Calcium deficiency disorders manifested in the construction of the bones (osteoporosis) and iron metabolism. The symptoms are: rickets, cramps and muscle tremor, osteoporosis.
Excess resulting from an overdose of calcium supplements containing vitamin D3 for children and adults overdose of calcium (hypercalcemia). Symptoms of hypercalcemia are: lack of appetite, vomiting and constipation.
The dosage administered in various publications are inconsistent: 800 - 1000 mg / 24 h (100 - 500 mg / 24h)
Vitamin B1 (thiamin, vitamin B) improves mental alertness and strengthens the nervous system ensuring the proper functioning of the brain. It improves cardiac and muscular system. It is suportive in the treatment of shingles. Involved in the metabolism of carbohydrates and fats. Natural source of vitamin B1 are brown bread, yeast, eggs, raw vegetables, meat, milk, legumes, cheese.
Vitamin B1 deficiency hinders the processes of decomposition of sugars (catabolism), causes a loss of appetite and disorders in the functioning of the digestive tract, can cause polyneuritis and disease beriberi.
Dosage: Recommended daily intake is 1-2 mg.
Vitamin B2 (riboflavin) is soluble in liquids, is involved in the metabolism of proteins, fats and carbohydrates. Required for growth of the organism. Takes part in the production of erythrocytes (red blood cells). It is located in natural foods, such as yeast, meat (especially liver, kidney, heart), milk, fish and green leafy vegetables.
A deficiency of vitamin B2 inhibits the growth, diseases of the mouth, loss and greasy hair, seborrhea and stratification of nails. Increases skin roughness and susceptibility to acne and oily skin.
Dosage: 1-2 mg per day.
Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) is soluble in the liquid. It participates in the metabolism of proteins, fats and carbohydrates. By reducing the amount of fat in the blood do not enable deposition of the body. It helps the absorption of magnesium and vitamin B12 (cobalamin). It works on the muscle antispasmodic and anti-inflammatory pain in the joints. It acts anti. It provides efficient operation of the brain. It increases energy increasing vigor of a man. The demand for vitamin B6 increases during pregnancy and breast-feeding infants. The natural product is: yeast, eggs, wheat germ, meat (liver), wheat bran, nuts, peanuts peanuts, soybeans. There is a hypothesis that can be synthesized by intestinal bacteria.
Deficiency of vitamin B6 causes abnormal metabolism of proteins, decrease in lymphocytes in the blood, causes a feeling of lethargy and fatigue intensifies.
Dosage: 1.5-2.5 mg daily (increased demand during pregnancy and lactation).
Vitamin B3 (vitamin PP, niacin, nicotinic acid, nicotinamide) is niacinamide niacin. It is used in interaction with vitamins B1, B2 and B6 in the synthesis of hormones during lactation. It provides proper functioning of the brain and nervous system. It is helpful in inflammatory conditions of the skin. Required for synthesis of sex hormone, estrogen, testosterone, cortisone, and insulin. It does not lose its properties in the manufacturing and storage. The source of acquiring vitamins PP are both products of animal origin (the lean meat, eggs, fish) and vegetable origin (dates, figs, hazelnuts, plums).
Dosage: 2-12 mg / day for children, 14 mg / day for women, 16 mg / day for men and 17-18 mg / day for pregnant or nursing women.
Inositol is an organic compound from the group of B vitamins soluble in fluids, present in the natural or synthetic form, synthesized in plants, such as brewer's yeast, beans, grapefruit, cabbage, sprout of wheat, melons and animal (liver). Along with choline is included in the lecithin. It affects the cell nutrition of the central nervous system (brain) by reducing the level of LDL (bad cholesterol), this makes it applicable in treatment of Alzheimer's disease and atherosclerosis. It has a calming effect. There has been a beneficial effect of inositol on the skin and hair reported.
Para-aminobenzoic acid (PABA) is soluble in water, part of the vitamin B complex. Synthesized in the body. Participates in energy conversion (metabolism) of proteins. Used in ointments to prevent excessive sun exposure, protecting against ultraviolet radiation. Positive effect on the condition of the skin and hair. According to a recent study, in conjunction with folic acid, allows to restore hair natural colour on gray. Synthesized in the body. Natural source of acquisition are: brewer's yeast, wheat germ, bran, whole grains, and rice and products of animal origin: liver and kidneys.
Dosage - the lack of strict standards daily dose
Quatrefolic is the glucosamine salt of (6S)-5-methyltetrahydrofolate and also an active form of folic acid. It is an innovative nutrient (fourth generation folate) which is well soluble in water and thus absorbed effectively by the body. As an organic compound ranked among B vitamins, it is necessary for normal functioning at the cellular level.
Adding folates to a diet is recommended especially to pregnant and lactating women. These compounds may contribute to healthy foetal development. According to studies, their intake may reduce the incidence of pregnancy complications.
Some sources report that folate supplementation supports cardiovascular function (blood production) and contribute to healthy immune function.
Quatrefolic may affect the metabolism of homocysteine whose levels increase in the body over time. Adding it to a diet may thus prevent the development of dementia and maintain healthy cognitive functions which is vital to adults, especially the elderly.
Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl
Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).
Biotin (vitamin H, co-enzyme R) is in a group of B vitamins, due to the presence of sulphur compounds it is involved in the synthesis of ascorbic acid (vitamin C). Also synthesized in the intestines. It enhances the production of hormones and regulates cholesterol levels. It reduces muscle pain. It prevents hair loss and graying of hair. It soothes the skin inflammations. No toxic effects. Often combined with other B group vitamins and vitamin A. The natural sources of biotin are: whole grain bread, yeast, eggs (yolk), milk, brown rice and cheese.
Daily demand: 100-300 mg per day
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