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Doctor's Best Bacopa With Synapsa is a dietary supplement which restores natural balance of the nervous system and increases its efficiency. The preparation containes patented form of Bacopa monnieri, standardised for the 55% content of bacosides, which positively influences cognitive functions – improves memory, responsiveness and mind sharpness as well as shows adaptogenic properties.
Bacopa monnieri is considered to be the most valuable plant in the Ayurveda, the traditional Indian medicine. The plant is also known under the name Brahmi, which originates from the name “Brahma”, one of the gods in Hinduism. The raw material has been used for more than 5 thousand years in India for calming down, reducing anxiety and supporting treatment of epilepsy and insomnia. B. monnieri extracts are used for improving memory and concentration in both young and elderly people.
Bacopa monnieri is a source of many bioactive substances. The most powerful ones are steroid saponins – bacosides A and B. Other substances include i.a. phenolic compounds and flavonoids (luteolin and apigenin), which show antioxidant and anti-inflammatory properties, betulinic acid of anticancer properties and phytosterols which positively affect lipid management.
Anti-stress and memory-improving properties
Bacopa monnieri belong to adaptogenic plants. This means that the plant improves body system adaptation to changing environmental conditions and increases resistance to stress.
B. monnieri can modulate expression of Hsp70 gene, concentration of P450 cytochrome and functions of superoxide dismutase (SOD) as well as contributes to an increase in kinase activity and stimulates neurogenesis, so that it has also anti-stress and anti-anxiety properties.
It has been also observe that, in contrary to some anxiolytic drugs, the plant does not cause such side effects as amnesia. This is because Bacopa monnieri affects functioning of the limbic system and stimulates transmission of nerve impulses, which improves concentration and cognitive functions. Moreover, it contributes to an increase in acetylcholine availability in the hippocampus and parietal lobe, which is also associated with an increase in cognitive skills.
Antioxidant potential of B. monnieri
The presence of phenolic compounds and triterpenoid fraction in B. monnieri is responsible for its strong antioxidant properties. The plant extract stimulates activity of catalase (KAT), superoxide dismutase (GPx) oraz superoxide dismutase (SOD). Moreover, B. monnieri extract minimises damages caused by aluminium, a neurotoxic heavy metal which increases oxidative stress.
B. monnieri in depression treatment
It is assumed that bacosides contained in B. monnieri show antidepressant and antianxiety activity as well as reduce mental fatigue. The mechanism of plant action is not fully investigated yet, however, bacosides are supposed to be responsible for the whole process, as they contribute to the increase in dopamine and serotonin concentration.
The main role in the nervous system is credited to bacosides, which contribute to i.a. an increase in acetylcholine production, inhibition of lipid peroxidation in brain cells and modulation of monoaminergic transmitter metabolism. Moreover, B. monnieri participates in chelation of heavy metal ions, neutralisation of excessive free radicals and stimulation of antioxidant enzymes, so that it shows neuroprotective properties.
Protection of the digestive system
B. monnieri extract shows anti-ulcer properties, mainly thanks to the stimulation of factors responsible for the protection of mucous membranes and reduction in oxidative stress. It has been observed that B. monnieri affects also reduction in Helicobacter pylori activity, a bacterium which i.a. causes diseases of digestive system, especially gastric and duodenal ulcers.
To sum it all up, Doctor's Best, Bacopa With Synapsa is a dietary supplement which will be perfect in case of increased mental activity, stress reduction and improvement in well-being, memory and concentration, both in young and elderly people. The supplement can also bring additional benefits, such as support for body system detoxification, regulation of menstrual cycle, protection of digestive system and alleviating skin inflammations.
Standard dose established for B. monnieri amounts for about 300 mg (by the content of 55% of bacosides), which is a dose contained in one capsule and recommended by the manufacturer.
It seems that supplementation with B. monnieri with food is associated with higher tolerance of the body system and smaller risk of side effects. For better results, the manufacturer recommends regular supplementation for 8–12 weeks.
Physician-founded in 1990, Doctor’s Best is a science-based nutritional supplement company, offering more than 200 products, made primarily with branded ingredients that are thoroughly researched, manufactured to the highest quality standards, and rigorously tested every step of the way—from raw materials to finished product. We use only cGMP-certified manufacturing facilities. Doctor’s Best is committed to transparency through education and communication and strives to be crystal clear in what we offer, why and how we offer it.
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|per 1 capsule||amount||%DV|
|Bacopa Monnieri Whole Plant Extract (from Synapsa, Standardized to 55% Bacosides)||320 mg||†|
Modified Cellulose (vegetarian capsule), Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate (vegetable source).
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