• Optimizes he level of triglycerides and cholesterol, protecting cardiovascular system
• Slows down the progression of neurodegenerative diseases
• Stabilizes mood, helping in depression states
• Effectively stabilizesthe level of glucose in blood
• High dose of antioxidant substances
• Modulates the activity of GLUT4 receptors
• Improves insulin-sensitivity of cells
• Helps to better control body mass
• Inhibits the development of atherosclerotic plaque
• Influences the activity of AMPK kinase
• Cardioprotective effect
• Improves neurotransmission
• Supports liver work
• Friendly to vegetarians
• Metformin analogue

Douglas Labs Berberine Balance is a dietary supplement of the highest-quality, which offers the ingredients with multidirectional molecular activity - high-quality berberine with a wide spectrum of applications, promoting homeostasis of cardiovascular system, hormonal system, digestive and nervous systems. An additional advantage of this product is the presence of alpha-lipoic acid and extract from grape seeds - ingredients, which maximize the pace of activity of the main active substance, while they additionally have hepatoprotective and anti-inflammatory activity.

Berberine is a chemical substance extracted from the plant Berberis aristata, the main task of which is stabilization of glucose level in blood, however, it can also i.a. improve lipid profile and prevent the creation of atherosclerotic plaque and consequently - its negative complications.

Alpha-lipoic acid - a compound classified to active antioxidants, the spectrum of activities of which overlaps with the effects of berberine, which provides a cumulative effect and helps to protect health even better.

Grape seed extract constitutes richness of natural chemical compounds, the anti-inflammatory and antithrombotic activity of which allows to protect homeostasis of the organism in quite a different way.

Amazing power of the extract
Berberine is a chemical substance belonging to alkaloids, widely used in Chinese medicine, where locals derived it from various plant extract. The most popular plant, from which this compound is obtained is Berberisaristata.

On the molecular level, berberine is an activator of AMP kinase pathway, responsible for a range of positive metabolic effects, depending on the tissue, in which its activation took place. Studies carried out on the cells of the liver, adipose and muscle tissues proved that improper regulation of molecular processes in their insides leads to the problems with lipid-carbohydrate metabolism (i.a. hypertriglyceridemia and diabetes).

The activity of this alkaloid may be compared to the effects that popular hypoglycemic drugs cause (e.g. metformin) - they disturb the work of the respiratory chain, as a result of which lower amount of ATP is produced in cells. As a consequence, the accumulation of large amounts of AMP takes place, which is an inducer of AMPK pathway and is responsible for related effects.

The application of berberine results in decreasing the concentration of cholesterol and triglycerides in the blood serum, due to their decreased production in the liver. This supports the condition of the cardiovascular system at many levels, as this alkaloid not only limits the production of cholesterol, but also inhibits the uptake of oxidized cholesterol by phagocytes of the immune system, preventing the processes of development of atherosclerotic plaque.

Hypoglycemic influence of berberine is also appreciated, which consists in sensitizing muscle and adipose tissue to the presence of glucose in blood. The influence on the former tissue consists in increasing sensitivity to insulin (among people with insulin-resistance) or the uptake of glucose in the mechanism dependent on AMPK, the former, adipose tissue, under the influence of berberine secretes decidedly more adiponectin, which is an adipokine with anti-inflammatory and hypoglycemic effect.

Berberine in the face of other ailments
Scientific studies, which went beyond the scope of analyzing the influence of berberine on carbohydrate-lipid metabolism, proved that its positive effect is concerned with many systems.

One of the diseases, in which this alkaloid turns out to be helpful is polycystic ovary syndrome (PCOS). It was proven that “only” the stabilization of glycemia contributes to the elimination of a few symptoms - the concentration of insulin is decreased (reduction of hyperinsulinism), which helps to fight hyperandrogenism, which may be one of the causes of acne. An additional “bonus” is its antibacterial effect, which is reflected in the improvement of the composition of intestinal microflora.

Also neurological ailments are withheld or considerably limited under the influence of berberine. Alzheimer’s disease is characterized by the retention of structurally improper protein, which is beta-amyloid. Berberine inhibits its retention in nerve cells, preventing their degeneration.

Another positive effect in the central nervous system is inhibition of the activity of monoaminoxidase A - an enzyme braking down serotonin, i.e. endorphin responsible for good mood, the deficiency of which is noted in depression states. Berberine decidedly contributes to the improvement of mood and mitigation of depression states.

Multidirectional activity of the antioxidant
Alpha-lipoic acid belongs to the group of saturated carboxyl acids, which plays an important function in metabolic processes. Its supplementation clearly limits food intake, which is probably responsible for the “central system of appetite stimulation” placed in the hypothalamus. It is especially helpful during a monotonous process of weight loss.

Moreover, ALA intensifies the effects of berberine, related to the normalization of glucose concentration in blood, as it not only supports berberine in the influence on the AMPK pathway, but also, in its presence, more glucose transporters GLUT4 are produced, which are responsible for transporting glucose to muscles. Moreover, alpha-lipoic acid is a great antioxidant and therefore it considerably decreases the concentration of free radicals, which are the cause of many metabolic diseases.

Additional supporting activity of grape seeds
Grape seed extract plays a supportive role for the above mentioned ingredients - it is the source of many active substances, such as flavonoids, unsaturated fatty acids, proanthocyanidins and also vitamin E. All of them play an important anti-inflammatory, anti-aggregative role, protecting primarily cardiovascular system.

To sum up, Douglas Labs Berberine Balance is a supplement addressed to all people who want to universally take care of health. It is especially recommended to people prone to problems with carbohydrate-fat balance and consequently the risk of the cardiovascular system diseases.