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Life Extension SAMe is a dietary supplement in the composition of which there is S-adenosylmethionine – endogenous compound conditioning proper course of several dozen most important biochemical reactions in the organism. Each tablet provides 400 mg of pure S-adenosylmethionine and the form of gastro-resistant capsule secures the active substance from damage or deactivation in acidic gastric environment.
The preparation has multidirectional effect. It may play the function of gentle antidepressant – it facilitates maintaining positive, stable mood, decreases depression-anxiety disorders, is ideal for people dealing with lower mood and blues. It has nootropic properties, therefore it is recommended to people aiming at increasing cognitive functions and supporting memory. It is worth applying also to mitigate the symptoms of osteoarticular system and in liver disorders.
S-adenosylmethionine (Adomet, SAMe, SAM) is a substance naturally appearing in the human organism, synthesized from methionine and adenosine triphosphate with the participation of folic acid and vitamin B12. The presence of SAMe conditions proper course of more than 50 different chemical reactions taking place in the system, including one of the most important – methylation.
All changes in the availability of SAMe in the organism are negatively reflected in cellular functions. SAMe deficiencies are primarily reflected in the impairment of liver work and neurological disorders. Researchers suggest that increasing the concentration of SAMe in the system may facilitate many processes taking place in the body, which in turn affects the improvement of general physical and mental well-being.
SAMe for good mood
SAMe is one of very few substances, which have the ability to permeate blood-brain barrier. Thanks to this, it quickly gets directly to the target place of its activity, i.e. central nervous system.
The basic benefit from using SAMe is decreasing the symptoms of depression. This substance influences the synthesis of the group of neurotransmitters, on which mental well-being depends. It increases the level of serotonin and dopamine. Its strength and effectiveness is comparable to popular antidepressants (e.g. imipramine). Similarly to them, it stabilizes our mood, decreases anxiety, ensures psychical peace, proper energy level and motivation. It was proven in a few studies that even patients, among whom traditional treatment with drugs from the group SSRI did not bring benefits, reacted to SAMe.
Importantly, SAMe brought effects quicker than in case of synthetic antidepressants. It is also safer than classic drugs, does not cause typical side-effects for antidepressant drugs, such as weight gain, constipation or lower libido.
SAMe for mental ability
SAMe has nootropic properties, therefore it is worth applying in order to improve mental efficiency. It reacts with cholinergic system and contributes to increasing density of cholinergic receptors, thanks to which it supports learning processes and strengthens memory.
SAMe takes part in the synthesis of phosphatidylcholine – the substance responsible for maintaining proper liquidity and permeability of mucous membranes and proper cellular signaling. SAMe deficits impair the production of phosphatidylcholine, due to which cognitive efficiency is decreased, the ability to concentrate drops and the pace of knowledge acquisition is slowed down.
SAMe is used in the processes of forming myelin sheaths, which surround neurites of nervous cells and are responsible for proper conduction of nerve impulses. Efficient synaptic transmission in practice means immediate fact association, lack of difficulties in recalling necessary information, the ability of logical and analytical thinking and fast acquisition of new knowledge.
Research shows that SAMe has neuroprotective potential and may be used both in prevention and therapy of Alzheimer’s disease. Practically in all patients with neurodegenerative diseases lower concentration of SAMe in the brain and cerebrospinal fluid is observed. Supplementing its level may prevent the deterioration of cognitive functions and in case of benign dementia to a certain extent it may even restore lost mental efficiency.
SAMe for the musculoskeletal system
SAMe has analgesic, anti-inflammatory and anti-swelling effect. It works well especially in the symptoms of osteoarticular system.
SAMe conditions binding sulfate groups to proteoglycans, which create the structure of bones and influence the compressibility of cartilage. Thanks to this, it intensifies the production of cartilage and protects it from degradation, caused by the activity of the factor TFN-alpha. It limits the production of pro-inflammatory cytokines, decreasing swelling in joints, attacked by a disease.
It was proven in the studies carried out on people with a degenerative disease that therapy with SAMe slowed down the development of the disease and contributed to increasing mobility in joints. SAMe was equally effective in treating pain as NSAIDs, while contrary to them, it did not cause any side-effects.
SAMe effectively decreases the symptoms of fibromyalgia and may contribute to permanent remission of the disease. People applying 400 mg of SAMe for a few weeks observed considerable reduction of pain symptoms. The number of trigger points, that usually reacted on pressure with pain was also decreased.
SAMe for liver protection
SAMe deficiency at first impairs liver functions. SAMe plays a leading role in regeneration of this organ and supports therapies of liver function disorders. It may be helpful in case of hepatocirrhosis (also due to alcohol), prevents damages of hepatocytes caused by pharmaceuticals, especially paracetamol and steroids.
SAMe contributes to increasing the concentration of glutathione – the most important endogenous cellular antioxidant. It is responsible for sweeping the excess of free radicals, protects liver cells from oxidative stress, unburdens the liver, supporting the process of detoxification.
Summing up, SAMe contains a safe compound, as naturally produced in the organism, which when used as a supplement brings many benefits to health. It is recommended especially to elderly people, complaining about symptoms of the osteoarticular system and lowering mental ability. It may be also helpful in case of depression and in disorders of liver work.
The supplement with nootropic and antidepressant effect. It may be also used in case of liver function disorders and in order to mitigate osteoarticular symptoms.
SAM is a safe, non-toxic and usually well-tolerated substance. Regardless of the aim of the therapy (improvement of liver function, support for the osteoarticular system, help in the fight with depression), tablets should be applied in divided doses, preferably on an empty stomach.
For optimal effects, supplementation should be enriched in vitamin B12 and folic acid.
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|per 1 tablet||amount||%DV|
|S-Adenosyl Methionine||400 mg||-|
cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, stearic acid, silica, glyceryl triacetate, sodium starch glycolate, croscarmellose sodium, titanium dioxide, yellow ochre.
Exogenous methionine is an amino acid containing sulphur in its composition. It provides multi metabolism, with the indispensable help of vitamin B6. Participates in the synthesis of phospholipids (e.g. Lecithin), carnitine responsible for transport in the body of long-chain fatty acids, burned in the mitochondria cells (organelles in cells with a separate kernel), along with cystine forms cysteine. It is in the body antioxidant function. Natural source of acquisition of methionine are high-protein foods of animal origin (eggs, meat, fish), vegetable (sesame seeds, grain products). Available in all protein and carbohydrate protein and amino acid supplements such EAA and contain so-called all-day amino acids, supporting the liver preparations and cosmetics supporting the growth and condition of hair, skin and nails.
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