Blog us   | en | USD
0 0.00 $  +1 844-530-3647
Since 2005
Notify me of availability
SAMe SAMe 400mg 30 tab.
Life Extension
40.80 $
Location: eu


All variants:

From 3 units only: 39.99 $ / Units. -2%

Shipping weight: 200g
40.80 $With VAT
1.36 $ / serving
We can let you know you when the product will be available again
  • Positively influences psychological well-being
  • Supports health of osteoarticular system
  • Prevention of neurodegenerative diseases
  • Restores proper functioning of the liver
  • Has anti-inflammatory and analgesic effect
  • Takes part in methylation processes
  • Protects from dementia
  • Decreases the symptoms of fibromyalgia
  • Facilitates detoxification process
  • Supports the immune system
  • Improves learning abilities
  • Supports cognitive functions
  • Stimulates glutathione synthesis
  • Has nootropic properties
  • Alleviates the symptoms of depression

Life Extension SAMe is a dietary supplement in the composition of which there is S-adenosylmethionine – endogenous compound conditioning proper course of several dozen most important biochemical reactions in the organism. Each tablet provides 400 mg of pure S-adenosylmethionine and the form of gastro-resistant capsule secures the active substance from damage or deactivation in acidic gastric environment.

The preparation has multidirectional effect. It may play the function of gentle antidepressant – it facilitates maintaining positive, stable mood, decreases depression-anxiety disorders, is ideal for people dealing with lower mood and blues. It has nootropic properties, therefore it is recommended to people aiming at increasing cognitive functions and supporting memory. It is worth applying also to mitigate the symptoms of osteoarticular system and in liver disorders.

S-adenosylmethionine (Adomet, SAMe, SAM) is a substance naturally appearing in the human organism, synthesized from methionine and adenosine triphosphate with the participation of folic acid and vitamin B12. The presence of SAMe conditions proper course of more than 50 different chemical reactions taking place in the system, including one of the most important – methylation.

All changes in the availability of SAMe in the organism are negatively reflected in cellular functions. SAMe deficiencies are primarily reflected in the impairment of liver work and neurological disorders. Researchers suggest that increasing the concentration of SAMe in the system may facilitate many processes taking place in the body, which in turn affects the improvement of general physical and mental well-being.

SAMe for good mood
SAMe is one of very few substances, which have the ability to permeate blood-brain barrier. Thanks to this, it quickly gets directly to the target place of its activity, i.e. central nervous system.

The basic benefit from using SAMe is decreasing the symptoms of depression. This substance influences the synthesis of the group of neurotransmitters, on which mental well-being depends. It increases the level of serotonin and dopamine. Its strength and effectiveness is comparable to popular antidepressants (e.g. imipramine). Similarly to them, it stabilizes our mood, decreases anxiety, ensures psychical peace, proper energy level and motivation. It was proven in a few studies that even patients, among whom traditional treatment with drugs from the group SSRI did not bring benefits, reacted to SAMe.

Importantly, SAMe brought effects quicker than in case of synthetic antidepressants. It is also safer than classic drugs, does not cause typical side-effects for antidepressant drugs, such as weight gain, constipation or lower libido.

SAMe for mental ability
SAMe has nootropic properties, therefore it is worth applying in order to improve mental efficiency. It reacts with cholinergic system and contributes to increasing density of cholinergic receptors, thanks to which it supports learning processes and strengthens memory.

SAMe takes part in the synthesis of phosphatidylcholine – the substance responsible for maintaining proper liquidity and permeability of mucous membranes and proper cellular signaling. SAMe deficits impair the production of phosphatidylcholine, due to which cognitive efficiency is decreased, the ability to concentrate drops and the pace of knowledge acquisition is slowed down.  

SAMe is used in the processes of forming myelin sheaths, which surround neurites of nervous cells and are responsible for proper conduction of nerve impulses. Efficient synaptic transmission in practice means immediate fact association, lack of difficulties in recalling necessary information, the ability of logical and analytical thinking and fast acquisition of new knowledge.

Research shows that SAMe has neuroprotective potential and may be used both in prevention and therapy of Alzheimer’s disease. Practically in all patients with neurodegenerative diseases lower concentration of SAMe in the brain and cerebrospinal fluid is observed. Supplementing its level may prevent the deterioration of cognitive functions and in case of benign dementia to a certain extent it may even restore lost mental efficiency.

SAMe for the musculoskeletal system
SAMe has analgesic, anti-inflammatory and anti-swelling effect. It works well especially in the symptoms of osteoarticular system.

SAMe conditions binding sulfate groups to proteoglycans, which create the structure of bones and influence the compressibility of cartilage. Thanks to this, it intensifies the production of cartilage and protects it from degradation, caused by the activity of the factor TFN-alpha. It limits the production of pro-inflammatory cytokines, decreasing swelling in joints, attacked by a disease.

It was proven in the studies carried out on people with a degenerative disease that therapy with SAMe slowed down the development of the disease and contributed to increasing mobility in joints. SAMe was equally effective in treating pain as NSAIDs, while contrary to them, it did not cause any side-effects.

SAMe effectively decreases the symptoms of fibromyalgia and may contribute to permanent remission of the disease. People applying 400 mg of SAMe for a few weeks observed considerable reduction of pain symptoms. The number of trigger points, that usually reacted on pressure with pain was also decreased.  

SAMe for liver protection
SAMe deficiency at first impairs liver functions. SAMe plays a leading role in regeneration of this organ and supports therapies of liver function disorders. It may be helpful in case of hepatocirrhosis (also due to alcohol), prevents damages of hepatocytes caused by pharmaceuticals, especially paracetamol and steroids.

SAMe contributes to increasing the concentration of glutathione – the most important endogenous cellular antioxidant. It is responsible for sweeping the excess of free radicals, protects liver cells from oxidative stress, unburdens the liver, supporting the process of detoxification.

Summing up, SAMe contains a safe compound, as naturally produced in the organism, which when used as a supplement brings many benefits to health. It is recommended especially to elderly people, complaining about symptoms of the osteoarticular system and lowering mental ability. It may be also helpful in case of depression and in disorders of liver work. 

Directions for use
Reviews (0)


Container size: 30 tabletsServing size: 1 tabletServings per container: 30
per 1 tabletamount%DV
S-Adenosyl Methionine400 mg-

Other ingrednients

cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, stearic acid, silica, glyceryl triacetate, sodium starch glycolate, croscarmellose sodium, titanium dioxide, yellow ochre.

Similar products
Best to combine with



Exogenous methionine is an amino acid containing sulphur in its composition. It provides multi metabolism, with the indispensable help of vitamin B6. Participates in the synthesis of phospholipids (e.g. Lecithin), carnitine responsible for transport in the body of long-chain fatty acids, burned in the mitochondria cells (organelles in cells with a separate kernel), along with cystine forms cysteine. It is in the body antioxidant function. Natural source of acquisition of methionine are high-protein foods of animal origin (eggs, meat, fish), vegetable (sesame seeds, grain products). Available in all protein and carbohydrate protein and amino acid supplements such EAA and contain so-called all-day amino acids, supporting the liver preparations and cosmetics supporting the growth and condition of hair, skin and nails.


Latest on blog

Moringa – an ancient plant with modern uses

Moringa – an ancient plant with modern uses

Most of today’s medicines are found due to the natural discoveries of our ancestors. For hundreds of years, nature has provided an opportunity to extract...

Read more

Refeed Day

Refeed Day

Have you been on a weight loss protocol for a few months? In the beginning, the weight was falling off nicely until you reached the stagnation, you continue to...

Read more

Curcumin – natural anti-inflammation drug

Curcumin – natural anti-inflammation drug

Curcumin – infoHow to take curcumin? Curcumin – info Regular use of curcumin reduces inflammation and blood sugar levels. Researchers studied 117...

Read more

How to protect yourself from smog?

How to protect yourself from smog?

The level of pollution in our cities is unfortunately constantly increasing. There are many reasons for this and while we should start from ourselves to start...

Read more

Best Vitamin C sources

Best Vitamin C sources

Vitamin C (ascorbic acid) is an ever hot topic that is constantly up due to frequent news of more and more potential health properties. Many people pay attention...

Read more

How to start losing weight?

How to start losing weight?

The decision to start losing weight often comes surprisingly easy. For some people, the critical look at the mirror is enough, for others health is the main...

Read more

Sign up for our newsletter
And receive coupons, news, special offers and much more!

Customer service

MZCatalog - recommended dietitians

MZCatalog - recommended trainers

MZCatalog - recommended clubs

Also check out our excellent ratings on  Opineo
Supps4You LLC
Unit 3 Enterprise Court, Farfield Park Rotherham S63 5DB +44 7767803657