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|IntiMe 30 caps.
Saccharomyces Boulardii + MOS is a supplement containing probiotic yeast cultures: Saccharomyces boulardii, and mannan oligosaccharides (MOS) that function as prebiotics. Using the preparation helps to maintain the normal condition and functions of the intestinal microbiome; it also exhibits strong antidiarrhoeal properties.
Saccharomyces boulardii is a non-pathogenic yeast strain characterised by the growth temperature of 37oC, resistance to the activity of antibiotics, low pH and bile. Thanks to the above-described properties, the probiotic can easily reach the intestine, develop there and influence the human organism in a positive way. Saccharomyces boulardii is believed to be a safe and well-tolerated strain.
When it comes to lipopolysaccharides produced by E. coli (LPS), Clostridium difficile toxins A and B, as well as the cholera toxin, Saccharomyces boulardii exhibits antitoxic properties. The strain synthesises antitoxins – proteins characterised by great enzymatic activity which allows them to reduce water and sodium secretion to the lumen of the small intestine, alleviate the troublesome symptoms of diarrhoea, and neutralise the harmful substances produced by pathogenic bacteria.
Its antimicrobial effect stems from the fact that the strain Saccharomyces boulardii helps to stabilise the intestinal mucosa and inhibit the development of pathogenic strains (for example, C. difficile, Salmonella spp., Shigella spp., Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and E. coli). When the intestine is infected with various pathogenic bacteria, the tight junctions between enterocytes are destroyed. Pathogens stick to intestinal cells, permeate inside them and cause their death. That leads to the set of negative symptoms we call diarrhoea.
Using antibiotics distorts the balance of the intestinal microflora composition, which, in turn, disturbs its functioning. Saccharomyces boulardii participate in the modulation of the intestinal microflora by reactivating the formation of short-chain fatty acids (SCFAs) that play an important role in water and electrolyte resorption and in preventing acute diarrhoeas.
The oral administration of Saccharomyces boulardii helps to strengthen the immune system and modulate both the innate and the acquired immune response. Supplementing the probiotic stimulates antibody synthesis, cytokine production and regulatory lymphocyte T activation. It is worth noting that its positive effects is observed even in the case of underdeveloped immune systems.
One of the most typical properties of the Saccharomyces boulardii yeast is its enzymatic activity, particularly helpful in the case of viral infections. The yeast participates in the formation of polyamines, which accelerate the maturation of enterocytes, cells that produce major digestive enzymes – disaccharidase and metalloprotease. Disaccharidases participate in the breakdown of disaccharides (sucrose, lactose and maltose) into monosaccharides. They are found along the brush border membrane of differentiated mature enterocytes.
Weakened activity of the enzymes leads to the deposition of osmotically active polysaccharides (such as lactose, maltose and sucrose) in the intestinal lumen and excess water along with them, which may result in acute diarrhoea. Only fully developed enterocytes are able to synthesise disaccharidases.
Scientific studies demonstrate that using S. boulardii in acute infectious diarrhoea treatment among children is justifiable, as well as in preventing the diarrhoea caused by antibiotic treatment both in children and in adults. The probiotic yeast strain is also believed to be efficient in preventing recurrent Clostridium difficile infections and travellers’ diarrhoea. Using Saccharomyces boulardii during therapy against Helicobacter pylori increases the efficacy of eradication and reduces the risk of undesirable symptoms occurring, particularly diarrhoea.
Mannan oligosaccharides (MOS) provide nutritional substances that have a beneficial effect on the growth of healthy intestinal bacteria and exhibit positive activity in the lower parts of the gastrointestinal tract. By modulating the pH of the environment, they limit the development of pathogens, and thanks to their ability to bind pathogenic bacteria, they prevent their adhesion to the intestinal walls and help to excrete them with stool.
To sum up, Jarrow Saccharomyces Boulardii + MOS is a dietary supplement that proves fantastic as prevention and treatment in any type of diarrhoea (bacterial, viral, antibiotic-induced, travellers’, caused by enteral feeding).
1 capsule, 1-2 times a day.
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