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A complex of substances that maximally enhance stimulation and motivation
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Maximizes the rate of burning extra body fat
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Stimulates the physiological mechanisms involved in fat burning
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Helps to reduce the absorption of unnecessary calories from food
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Supports insulin and carbohydrate metabolism
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Inhibits the development of harmful inflammatory processes
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Intensifies cAMP production
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Helps to control the appetite
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Safe to use
Hi-Tech Pharmaceuticals Lipodrene Hardcore is a complex of ingredients containing many plant extracts, as well as isolated active substances that will effectively ensure an increase in metabolic rate and effective fat burning, as well as contribute to the delaying of the feeling of hunger.
Ephedra leaf extract is a source of substances that affect adrenergic receptors, which act using mainly beta receptors and may contribute to increased heat production in muscle tissue, thereby stimulating the burning of energy substrates, including fats released from adipocytes. Besides, the extract may reduce glucose uptake by adipose tissue cells, preventing fat deposition. Moreover, supplementation with Ephedra extract may promote an increase in blood pressure since it binds to alpha receptors on the precapillary sphincters.
Senegalia Berlanderi leaf extract contains a set of centrally acting substances. They facilitate adrenergic transmission, mainly with regards to norepinephrine, which contributes to increased peripheral lipolysis. Besides, their derivatives as well as phenylethylamine itself are known for their euphoric effect, thanks to which they improve well-being.
Citrus Aurantium extract is the main source of phenylethylamine, which at the molecular level binds to TAAR1 receptors in the central nervous system, inhibiting the reuptake of dopamine, serotonin, and noradrenaline. Dopamine and serotonin, as "happiness hormones", are responsible for improving mood and a feeling of pleasure, while noradrenaline increases blood pressure and helps to release triglycerides from adipocytes.
1,3-Dimethylamylamine (DMAA), otherwise known as geranium, is a substance whose action is based on blocking noradrenaline reuptake, thanks to which it stimulates the central nervous system, affecting the increase of exercise capacity, reduction of fatigue and acceleration of metabolism. Another desirable action of geranamine is a significant increase in thermogenesis.
Cassia Nomame extract has an inhibitory effect on the action of an enzyme called pancreatic lipase, which is involved in the process of breaking down fats. It enables their conversion into monoglycerides and fatty acids, followed by their absorption in the small intestine. The lack of this process reduces the amount of calories consumed with food, thus facilitating the achievement of caloric deficit and reduction of body fat by initiating lipolysis.
Naringen is a plant-derived compound belonging to flavonoids that has a broad spectrum of activity. It helps in the fight against excess body fat and lipid panel disorders, as it can induce adipocyte apoptosis and also inhibit one of the key enzymes in cholesterol production – HMG-CoA reductase. In addition, it has been proven to have anti-inflammatory and antioxidant effects.
6,7-Dihydroxybergamotin is contained in grapefruit juice and shows quite a specific inhibitory activity against the enzymatic complex in the liver – cytochrome P450. It is responsible for the metabolism of many substances, including drugs. As an addition to supplements, it is designed to facilitate their bioavailability.
Evodiamine is an alkaloid isolated from fruit found in China. It contributes to the increased production of catecholamines, which directly increase the concentration of cAMP in adipose tissue cells, enabling their emptying.
5-methoxytryptamine hydrochloride is a full agonist of serotonin receptors in the central nervous system. The compound is credited with the ability to affect the secretion of leptin, a 'satiety hormone' that prevents excessive snacking and facilitates weight control.
Yohimbe extract is characterized by the presence of yohimbine, a chemical compound that acts as an alpha2 receptor antagonist, thanks to which it allows the release of noradrenaline without its inhibition. Substances belonging to polyphenols and other chemical compounds found in the extract, in turn, contribute to the improvement of insulin sensitivity of cells, blood lipid profile, and muting existing inflammatory processes.
Yerba Mate Extract – an extract of dried leaves of Ilex Paraguariensis, a tree growing in South America. It is rich in various bioactive substances, including polyphenols and purine alkaloids. Yerba Mate, by modulating the signaling pathways that regulate the process of adipogenesis, inhibits the preadipocyte differentiation and decreases the accumulation of fat and inflammation occurring within the fat tissue. Thanks to the content of chlorogenic acid, it modulates the activity of glucose-6-phosphatase, an enzyme involved in glucose metabolism. Also, it optimizes the lipid profile and has antioxidant and stimulating effects.
Green tea extract is a wealth of ingredients, mainly methylxanthines, as well as epicatechins. The latter contribute, among others, to decreasing the perceived hunger by affecting the secretion of neurotransmitters as well as delaying gastric emptying. They may also sensitize the tissues to insulin.
Theobroma Cacao extract – a source of theobromine, methylxanthine, which in addition to the participation in fat burning allows for more effective absorption of epicatechins contained in green tea extract. It also improves the lipid profile, shows anti-inflammatory properties, and may also lower blood pressure.
To sum up, Hi-Tech Pharmaceuticals Lipodrene Hardcore is a supplement intended primarily for people who want to intensify the process of body fat reduction. The combination of ingredients inducing catecholamine and methylxanthine secretion will enable the enzymatic apparatus of the lipolysis process, whereas the polyphenols, epicatechins, and pancreatic lipase inhibitors will contribute to additional effects in the form of delayed hunger, tissue sensitization to insulin, or reduction in caloric intake.
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