Blog us   | en | USD
0 0.00 $  +1 844-530-3647
Since 2005
Notify me of availability
Synadrene Synadrene 45 caps. (US version)
49.31 $
Location: eu


All variants:

From 3 units only: 48.32 $ / Units. -2%

Shipping weight: 180g

As an alternative, we recommend:

Mesomorph v4 388g
Mesomorph v4 388g
49.31 $
Compare composition
49.31 $With VAT
1.10 $ / serving
We can let you know you when the product will be available again
  • Accelerates metabolism
  • Helps to burn fatty tissue
  • Helps to reduce feeling of hunger
  • Boosts energy and vitality
  • Enhances CNS functions
  • Improves concentration
  • Enhances cognitive functions
  • Increases exercise capacity

HI-TECH Synadrene is a fat burner containing vitamins of the B complex (B12, B3, B6), chromium, and a proprietary blend of such ingredients as: DMAA, yohimbine, ALA, sulbutiamine, a green tea extract, and methylxanthine. Thanks to its amazing contents, the preparation can increase the level of physical and mental energy, reduce appetite, and stimulate metabolism, which translates into better results during the periods of fatty tissue reduction.

The group of methylxanthines consists of caffeine, theobromine, and theophylline. Their effects stem not only from the ability to inhibit the breakdown of cAMP and cGMP in cells, but also from their antagonist activity to adenosine receptors. The substances exhibit various affinity and power of activity regarding the enzymes phosphodiesterases and adenosine receptors, thanks to which they have different pharmacological properties. Theophylline causes the dilation of bronchi and blood vessels, while caffeine and theobromine exhibit the ability to stimulate the organism, increase heat production and reduce the symptoms of tiredness. Methylxanthines have a beneficial effect on the oxygen management of the organism on the activation of other effects, thanks to which they increase exercise capacity.

The green tea extract helps to lose weight effectively by affecting the reduction of appetite and the inhibition of fat digestion. The main active components, polyphenols, are one of the most powerful substances when it comes to antioxidant potential. Moreover, green tea contains a large amount of epigallocatechin gallate (EGCG) whose antioxidant properties can be even 100 times stronger than those of vitamin C. When combined with the other ingredients of the supplement, the extract helps to maintain good health and supports your efforts during the periods of fat burning.

1,3-Dimethylamylamine HCL (DMAA, geranamine) is one of the stronger components you can find in pre-workout supplements and thermogenics. DMAA leads to an increase in noradrenaline levels, which causes the stimulation of the CNS, an improvement in exercise capacity, and an increase of concentration and thermogenesis.

Sulbutiamine is a vitamin B1 derivative; it is built from its two subunits, and its main property is the nootropic effect. The substance helps to increase the performance of the nervous system, stimulate mental processes, and enhance cognitive functions.

Thanks to its lipolytic properties, yohimbine is a substance commonly used in order to reduce fatty tissue. There is plenty of scientific evidence that it is a blocker of α2-adrenergic receptors, thanks to which it enables more efficient energy generation from free fatty acids stored in cells, which speeds up the process of weight loss. Because of its possible effect on the increase in adrenaline and noradrenaline secretion, it is used as a stimulant for increasing the activity of the sympathetic nervous system. Its unique property reported by its users is the ability to eliminate fat from the most resistant spots, such as the abdomen, thighs or buttocks. Moreover, it is worth noting that yohimbine can improve sexual experience and performance and increase the libido.

Alpha-lipoic acid (ALA) is an antioxidant that improves the organism’s ability to absorb and transform carbohydrates into energy (an insulin-like effect), which makes it a perfect help for reducing fatty tissue. ALA supplementation is safe and recommended on a diet rich in carbohydrates because it increases their absorption as well as that of other nutrients directly to muscles.

Poly-iiodo-thyronine is a thyroid hormone analogue that can become a product for triiodothyronine (T3) synthesis through deionisation. Having entered a cell, T3 binds with its specific nuclear receptor which initiates the right DNA sequence, affecting gene transcription. There occurs increased production of mitochondrial enzymes, which leads to a metabolic boost, increased oxygen consumption and heat production in the entire organism.

The main functions of vitamin B12 (cyanocobalamin) are: participating in carbohydrate, fat and protein metabolism, regulating the production of red blood cells, and affecting the normal functioning of the nervous system. Moreover, it takes part in regulating the level of homocysteine, which is believed to be an independent risk factor of developing neurodegenerative and cardiovascular system diseases, foetal malformations, and cancer.

Vitamin B3 (niacin) participates in energy metabolism, regulating blood cholesterol levels, erythrocyte production, reducing the toxic effect of drugs and chemical compounds, it has a beneficial effect on the nervous system and the mental condition, and improves the blood supply of the skin and the condition of hair.

Vitamin B6 (pyridoxine hydrochloride) increases the organism’s immunity and participates in the production of antibodies. It takes part in energy metabolism and the transformation of tryptophan into vitamin PP and increases the level of the vitamin in the organism. Pyridoxine is also essential for the production of porphyrins (haem synthesis for haemoglobin in the production of red blood cells) and hormones (like histamine, serotonin).

The addition of chromium in thermogenics helps to reduce appetite, control metabolism and maintain the results achieved. The element also plays an important role in the normal functioning of insulin receptors as a part of the glucose tolerance factor (GTF). The substance is produced in the liver and released to the blood during an increase in glucose or insulin levels. Along with insulin, it enables the permeation of glucose, amino acids and fatty acids to cells, and accelerates their metabolism.

To sum up, HI-TECH Synadrene is a dietary supplement that can boost energy for the entire day and accelerate metabolism when taken in the morning. When used before workout, it can help to increase concentration and the level of exercise capacity. It plays the role of a powerful fat burner and a strong stimulant. It is a perfect preparation for people who want to get rid of excess fatty tissue and enhance muscle definition. The product can also reduce appetite and eliminate the feeling of hunger. Thanks to the content of high-quality stimulants, you can feel an energy boost that will motivate you more to raise the game and achieve your goals. 

Directions for use
Reviews (0)


Container size: 45 capsulesServing size: 1 capsuleServings per container: 45
per 1 capsuleamount%DV
Vitamin B12 (as Cyanocobalamin)100 mcg1,666%
Vitamin B3 (as Niacin)20 mg100%
Chromium (from Chromium Polynicotinate)175 mcg146%
Vitamin B6 (as pyrdoxine HCL)4,25 mg212%
Synadrene Proprietary Blend:815 mg **
Caffeine Anhydrous, Green Tea Extract (leaves), 2-Aminoisoheptane HCl, Walnut Extract (bark), Sulbutiamine, Sandalwood Extract, Yohimbine Extract (bark), Alpha Lipoic Acid, Poly Thyronine

Other ingrednients

DiPotassium Phosphate, MCMC, Silicone Dioxide, Magnesium Stearate, Titanium Dioxide, FD&C Blue #1, FD&C Red #40, Gelatin

Similar products
Best to combine with



What is cyanocobalamin?

Cyanocobalamin is a basic, the most commonly met form of vitamin B12 in vitamin B complexes and multivitamins available on the market.

Vitamin B12 is the most known for its influence on neurology. It takes part in building and regenerating myelin sheaths of neurons, thanks to which it contributes to the protection of the nervous system against damages. Because of the ability to increase the level of S-Adenosyl methionine, vitamin B12 may contribute to more efficient synthesis of many neurotransmitters, thanks to which it positively influences well-being and psychical condition.

This vitamin is also engaged in the process of blood production and its deficiencies contribute to the creation of megaloblastic anemia. Its deficits may also concern vegetarians and vegans, elderly people, people with absorption disorders and those using drugs neutralizing gastric acid.

Cyanocobalamin is included in the composition of many complex vitamin supplements that may be found in the offer of

Vitamin B3


Vitamin B3 (vitamin PP, niacin, nicotinic acid, nicotinamide) is niacinamide niacin. It is used in interaction with vitamins B1, B2 and B6 in the synthesis of hormones during lactation. It provides proper functioning of the brain and nervous system. It is helpful in inflammatory conditions of the skin. Required for synthesis of sex hormone, estrogen, testosterone, cortisone, and insulin. It does not lose its properties in the manufacturing and storage. The source of acquiring vitamins PP are both products of animal origin (the lean meat, eggs, fish) and vegetable origin (dates, figs, hazelnuts, plums).
Dosage: 2-12 mg / day for children, 14 mg / day for women, 16 mg / day for men and 17-18 mg / day for pregnant or nursing women.




Chromium (chemical element from transition group of the chromium, chemically active) is actively involved in the metabolism of fats and carbohydrates. It comes in the easily assimilable organic form and inorganic. Along with insulin, as a component of the glucose tolerance factor (GTF), is used in insulin-dependent diabetes treatment, insulin involved in the metabolism of glucose in t proteins transport. Activator of enzymes involved in the metabolism of fats and cholesterol. Available in animal origin products (liver, veal, chicken, turkey meat, oysters) and plant-origin (bananas, broccoli, cereal, wheat germ, spinach). Supplements containing chromium are recommended for fat loss (also thermogenic), and improving the functioning of the body. The sports supplementation used chromium in the form of mono-preparations or in the form of vitamin-mineral minerals supplements.
Chromium deficiency results in impaired glucose, reducing the insulin sensitivity. It causes a decrease in immunity and endurance of the body. It may be a cause of coronary heart disease. Sometimes it causes neurological disorders.
Dosage: A varied diet prevents from the deficiency of chromium in the body.

Dosage: The recommended dose of 50-150 mg per day.


Chromium polynicotinate


Chromium polynicotinate, is an organic chemical compound made from the combination of trivalent chromium with vitamin PP (niacin, vitamin B3) included in the glucose tolerance factor (GTF), synthesized in the liver and increasing functional properties of insulin. Polynicotinate chromium has stabilizing effect on blood pressure. It has thermogenic potential, allowing for decreased appetite (especially for sweets), reduces the risk of developing diabetes, keeps the body in good physical condition. In the dietary supplementation, polynicotinate chromium is used in programs to reduce body fat and improve body composition, it is in the form of mono-preparation supplement and is a component of weight loss preparations (thermogenic), and vitamin and mineralizing supplements, available at
Dosage: 50 - 150ug / 24

Vitamin B6


Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) is soluble in the liquid. It participates in the metabolism of proteins, fats and carbohydrates. By reducing the amount of fat in the blood do not enable deposition of the body. It helps the absorption of magnesium and vitamin B12 (cobalamin). It works on the muscle antispasmodic and anti-inflammatory pain in the joints. It acts anti. It provides efficient operation of the brain. It increases energy increasing vigor of a man. The demand for vitamin B6 increases during pregnancy and breast-feeding infants. The natural product is: yeast, eggs, wheat germ, meat (liver), wheat bran, nuts, peanuts peanuts, soybeans. There is a hypothesis that can be synthesized by intestinal bacteria.
Deficiency of vitamin B6 causes abnormal metabolism of proteins, decrease in lymphocytes in the blood, causes a feeling of lethargy and fatigue intensifies.
Dosage: 1.5-2.5 mg daily (increased demand during pregnancy and lactation).


Proprietary blend


Proprietary blend - is a complex of bioactive ingredients in the proportions, which are covered by the manufacturer's patent. According to the law in force in Poland, the components of the blend are known, and , by the place on the packaging, you can identify which components are in bigger amount (the components are listed in the decreasing order of amounts).
Proprietary blends are used in many food supplements, such as creatine stacks, no-boosters, fat burners and pro-testosterone supplements, improving libido.




Caffeine (1,3,7-trimethylxanthine, 1-methylotheobromine) is a purine alkaloid occurring in the natural state in plants (Coffea arabica, Camelia sinensis, Paulinia cupana, Ilex paraguariensis), which acts as a natural pesticide, acting toxic to insects. Peculiar smell and taste also deters herbivores. Caffeine in the body inhibits the adenosine receptors in the brain, fighting fatigue and allowing for action activation. It has a beneficial effect on the metabolism of oxygen, which increases the exercise capacity (strength and endurance) and rapid post-workout recovery. In the sports supplementation, caffeine is used as a stimulant nervous system. It has the thermogenic potential and in combination with other substances (e.g. Polyphenols, both occurring in coffee beans, such as cocoa beans, tea leaves and mate) can effectively participate in the reduction of body fat. It is included in many dietary stimulants (creatine stacks, no-boosters, beverages). It is a component of fat burners. It is also in the form of mono-preparation supplements.
Dosage: 100-600 mg per day. Due to the long release of activity should not be used in the evening, before


Green tea extract


Green tea extract is a concentrate that contains biologically active compounds: polyphenols (e.g. catechin, in the form of EGCG - epigallocatechin gallate), having antioxidant properties and a small thermogenic potential, modifies the action of testosterone metabolites, DTH. Green tea extract is an ingredient of many sports supplements containing fat burners, having pro-health and vitaminizing effect; also for those with low physical activity as an antioxidant and slimming supplement. Available either as mono-preparations, ready drinks, and above all as an extract.
Dosage: 200-500 mg per day (depending of the content of other active bio-components).




Sulbutiamine – a syntetic derivative of vitamin B1, characterised by much higher absorption. It can penetrate biological membranes and cross the blood-brain barrier. According to studies, it shows neuroprotective properties (improves cognitive functions, mainly creativity, motivation and memory) and has health-promoting effects.

Due to its ability to penetrate the brain, it may increase levels of thiamine (to which it is metabolised). This influences greatly the modulation of neurotransmitters (as reported by studies, it increases the amount of dopamine receptors in the brain and is an important cofactor in acetylcholine synthesis) and neurons. Its nootropic effect is connected with the stimulation of metabolism in the central nervous system.

According to some sources, sulbutiamine may be effective also in individuals with different states of anxiety and depression. It has probably the ability to boost confidence and reduce inhibitions in persons with depressive disorders.

Sulbutiamine may be used successfully by athletes. As stated by scientists, it helps increase the body’s endurance, reduce time needed for recovery and boost energy required for physical activity. It may probably speed up blood flow and increase oxygenation levels.



Yohimbine is a natural component of the indole alkaloid yohimbine, ingredient of bark of yohimbe (Corynanthe yohimbe), a recognized aphrodisiac and increasing potency mean. It stimulates the nervous system by blocking the adrenergic receptors alpha-2. Tree bark of yohimbe is also a source of alkaloids (isoyohimbine, aloyohimbine), which can enhance its performance. With the right dosage, taken with caffeine on an empty stomach and a longer period before taking a meal, it enhances the process of lipolysis due to increased levels of norepinephrine in the body.
In the sports supplementation
it helps to reduce body fat (especially in programs of weight control and its composition), taken before physical activity. It comes in the form of mono-preparation supplements, extracts from yohimbe tree bark, synthetics and in supplements with thermogenic effect. Available for purchase at
Dosage: No specific dosage standards. Some sources give optimal dose of 0.2 mg / kg
of body weight (usually used at 5-10 mg per day).


Latest on blog

#21 Supplements review –Apollo’s Hegemony Zinc Bisglycinate

#21 Supplements review –Apollo’s Hegemony Zinc Bisglycinate

Zinc is one of the most important minerals in our diet. There is no doubt about it. Its adequate supply in our diet determines, among other things, the optimal...

Read more

Young barley – a natural weight loss remedy!

Young barley – a natural weight loss remedy!

Young barley has been gaining popularity over time especially for people who want to lose weight. The history of green barley dates back to ancient times. In...

Read more

Citrulline – a amino acid that supports workouts

Citrulline – a amino acid that supports workouts

Bodybuilding isn’t just about increasing muscle mass, it’s also about improving your body’s overall shape. If you follow an intensive training...

Read more

Roll out your pain!

Roll out your pain!

Achieving your dream figure and constant improvement of your performance depends not only on diet but also on regular physical activity. An important part of...

Read more

Moringa – an ancient plant with modern uses

Moringa – an ancient plant with modern uses

Most of today’s medicines are found due to the natural discoveries of our ancestors. For hundreds of years, nature has provided an opportunity to extract...

Read more

Refeed Day

Refeed Day

Have you been on a weight loss protocol for a few months? In the beginning, the weight was falling off nicely until you reached the stagnation, you continue to...

Read more

Sign up for our newsletter
And receive coupons, news, special offers and much more!

Customer service

MZCatalog - recommended dietitians

MZCatalog - recommended trainers

MZCatalog - recommended clubs

Also check out our excellent ratings on  Opineo
Supps4You LLC
Unit 3 Enterprise Court, Farfield Park Rotherham S63 5DB +44 7767803657