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Life Extension TMG is a supplement containing 100 mg of trimethylglycine (betaine anhydrous, TMG) in one portion. Its most important functions are the ability to osmoprotection and to move methyl groups. Thanks to these properties, TMG protects cells from osmotic pressure fluctuations and also takes part in many biochemical transformations especially important for the human organism, including homocysteine level.
Betaine anhydrous (trimethylglycine, TMG) structurally it is a glycine molecule with three methyl groups attached. It is obtained from such cereals as: rye, wheat, barley and also spinach, soya, shellfish and sugar beet. Trimethylglycine plays an important role in animals and humans in maintaining water balance of cells, coordinating the most important metabolic functions and inhibiting many disease-causing processes. Moreover, TMG may serve as a donor for methyl groups with the aim of lowering homocysteine concentration in the system.
Betaine takes part in biosynthesis of many key compounds which play an important role in protein metabolism. Thanks to the fact that it is the source of methyl groups, it takes part in creating such substances as: methionine, S-adenosylmethionine (SAM), carnitine and phosphatidylcholine.
Its physiological level in the human serum amounts to 20 to 75 µmol/l, but in certain organs, such as kidneys or liver, the presence of this substance is much higher. It easily permeates to, among others, kidney cells and accumulates there thanks to which it takes part in protecting the organism against high concentration of electrolytes and urea. Betaine is a lipoprotein, which means that it may prevent and limit fat accumulation in the liver. This activity is also related to efficient liver metabolism and prevention of excessive production of harmful ethanol and carbon tetrachloride.
TMG works as osmolyte and influences maintaining proper water balance in cells and tissues. Osmolytes are small, soluble organic cells. They positively influence stabilization of membranes and cell proteins as well as relocation of water between cells and the surrounding environment. At the same time, they don’t disturb metabolism and they don’t have any negative influence on cells. They can interchangeably be inside and outside a cell affecting its state of hydration. Additionally, they protect cellular micro-molecules (enzymes) from inactivation.
The influence on anabolism
Research showed that adding betaine to food positively influences the growth of bodyweight of animals and quality composition of meat. Similarly as in the case of creatine, increased intercellular betaine concentration promotes cell rehydration and it makes the environment even more prone to anabolic processes and increases the resistance to the activity of stress-forming factors. Such properties make TMG a great additive to sportsmen supplementation and physically active people which can contribute to the improvement of their scores.
Participation in homocysteine metabolism
TMG is an important functional, regulating element during the production of methionine from homocysteine. Blockages in homocysteine metabolism lead to its intercellular accumulation with the subsequent export to blood. Depending on the size of the disorders, its level in the plasma may increase to various degrees. Hyperhomocysteinemia is considered among people to be a risk factor of the development of cardiovascular and neurodegenerative diseases, developmental defects of the fetus and cancers. In the health statements of EFSA it is said that positive influence of betaine is observed at the doses of 0,5-2,5 g a day.
Summing up, Life Extension TMG is a dietary supplement which brings many health benefits. The product also constitutes a perfect element of cardiovascular diseases prophylaxis. It effectively regulates homocysteine metabolism and is recommended especially to people with methylation disorders, which are created as a result of polymorphism of MRHFR gene. The benefits of taking the preparation may be also derived by physically active people and sportsmen.
It is recommended to take 1 to 5 capsules a day, preferably in the morning during a meal. It is not recommended to take more than 5 capsules a day.
In order to increase the effectiveness, TMG should be taken with cooperating factors, such as vitamin B6, B12 and folic acid.
In case of muscle tensions or the appearance of headaches, the dose should be decreased or the application should be stopped until the symptoms resolve and then resume the supplementation starting from the lowest possible dose.
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Glycine is belongs to 22 essential amino acids (synthesized within the body) constructing proteins, and non-protein component of enzymes i.e. heme. It is a inhibiting neurotransmitter allowing for improvement in sleep comfort even at a dose of 3 g at bedtime. Glycine (as arginine) is a precursor of creatine. It is essential for the synthesis of a strong antioxidant - removing free radicals out of the body - glutathione. It is cholagogic and cholepoiteic. By interfering with the synthesis of growth hormone, accelerates the biological recovery of an organism. Naturally present in foods of plant and animal origin. In the sports supplementation is a component creatine stacks, amino acid supplements, protein supplements based on natural ingredients and carbohydrate and protein.
Betaine (N, N, N-trimethylglycine, the TMG) is methyl glycine derivative participating in the conversion of homocysteine to methionine. It is present in food of plant origin and produced by the body in the liver or kidneys. The medicine uses it in the treatment of gastrointestinal and digestive disorders and hyperhomocysteinemia. In the supplements that increase the level of homocysteine used together with glycocyamine, indirectly influences the endogenous synthesis of creatine. There is no mono-preparation supplement containing betaine. Available in creatine stacks and the detoxicating supplements.
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