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Life Extension TMG Powder is a dietary supplement containing pure trimethylglycine (TMG), also called betaine anhydrous, in the form of powder. The preparation supports maintaining proper homocysteine concentration in the organism.
TMG (trimethylglycine) also called betaine anhydrous, is a compound, which is an active metabolite of choline. This substance was discovered for the first time in beets (Beta vulgaris), to which it owes its name.
TMG can be found in plants (i.a. broccoli, spinach), animals and also naturally in the human organism and is responsible for lowering the level of homocysteine and also it takes part in the process of cell proliferation, facilitates carnitine production and supports liver functions.
TMG as a source of methyl groups
Betaine is a donor for three methyl groups (–CH3), which are crucial in the processes of many biochemical reactions. Thanks to them, such compounds may be created as: S-adenosylmethionine (SAM), phosphatidylcholine and carnitine.
By taking part in the process of methylation, which consists in passing one methyl group between molecules and then binding it to the enzyme responsible for a given function, betaine is a key element responsible for maintaining health.
It is commonly believed that problems with methylation, and more precisely mutation of MTHFR gene may concern even every second person. It results in, among others, the disorders of detoxification functions, improper synthesis of neurotransmitters and increased homocysteine level, which in turn may lead to the intensification of inflammations, circulatory system diseases and neurodegenerative disorders.
TMG and homocysteine concentration
Homocysteine is a sulfuric amino acid created as a result of methionine and cysteine transformations. Hyperhomocysteinemia distorts homeostasis and negatively influences the structure of endothelium cells and vessel elasticity, as a result of which it constitutes one of the risk factors of atherosclerosis and thromboembolic diseases and moreover it may lead to obstetric complications (neural tube damage, miscarriage, fetus development retardation).
Betaine anhydrous is considered to be one of homocysteine modulators. TMG moves the methyl group through the enzyme betaine-homocysteine S-methyltransferase (BHMT) and next it is transformed to dimethylglycine. TMG hands over one methyl group to homocysteine, which contributes to its methylation and causes the transformation to methionine.
Scientific research indicates that taking TMG reduces the level of this amino acid in the system and helps to restore its optimal level, which lowers the risk of vascular diseases.
TMG as creatine precursor
Betaine takes part in the process of creatine synthesis, thanks to which it may contribute to the increase of its intercellular level. Creatine fulfills many metabolic functions, i.a. it takes part in energy production in the system, supports strength growth and has anabolic properties as well as facilitates organism regeneration.
Anticatabolic properties of betaine
TMG increases the level of lean body mass and protects from storing fatty tissue. This amino acid has anabolic effect, which is connected to its important role in the process of methylation. TMG, by facilitating the reactions of methylation, limits the activity of ubiquitin, responsible for the activity of catabolic enzymes and the breakdown of muscle proteins.
Hepatoprotective effect of TMG
TMG is a substance soluble in water and belongs to the group of lipotropic substances, thanks to which it may counteract or reduce accumulating fat in the liver. Moreover, it protects liver cells against hepatotoxic substances, such as for example ethanol and carbon tetrachloride.
Summing up, Life Extension, TMG Powder is a dietary supplement recommended for general health and life quality improvement, especially among people prone to increased homocysteine concentration in the organism. Moreover, the preparation is recommended to people who want to reduce the excess of fatty tissue and to sportsmen who take care about high level of muscle tissue.
According to the European Food Safety Authority (EFSA), the beneficial effect resulting from using betaine is visible at the dose of 0,5-2,5 g a day.
In order to increase the effectiveness of the preparation, it is recommended to take it with cobalamin (vitamin B12), folic acid or choline. It is also possible to increase the level of these components by using food products which are their sources: choline (egg yolks, liver), folic acid (liver, lentil, asparagus), cobalamin (fish – salmon, mackerel and giblets).
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Glycine is belongs to 22 essential amino acids (synthesized within the body) constructing proteins, and non-protein component of enzymes i.e. heme. It is a inhibiting neurotransmitter allowing for improvement in sleep comfort even at a dose of 3 g at bedtime. Glycine (as arginine) is a precursor of creatine. It is essential for the synthesis of a strong antioxidant - removing free radicals out of the body - glutathione. It is cholagogic and cholepoiteic. By interfering with the synthesis of growth hormone, accelerates the biological recovery of an organism. Naturally present in foods of plant and animal origin. In the sports supplementation is a component creatine stacks, amino acid supplements, protein supplements based on natural ingredients and carbohydrate and protein.
Betaine (N, N, N-trimethylglycine, the TMG) is methyl glycine derivative participating in the conversion of homocysteine to methionine. It is present in food of plant origin and produced by the body in the liver or kidneys. The medicine uses it in the treatment of gastrointestinal and digestive disorders and hyperhomocysteinemia. In the supplements that increase the level of homocysteine used together with glycocyamine, indirectly influences the endogenous synthesis of creatine. There is no mono-preparation supplement containing betaine. Available in creatine stacks and the detoxicating supplements.
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