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Seeking Health Adeno B12 is a dietary supplement which contains the bioactive, mitochondrial form of vitamin B12, adenosylcobalamin. The product positively affects the health of the nervous and cardiovascular systems as well as can be an effective alternative to methylcobalamin for people hypersensitive to methylated forms of B-vitamins.
Vitamin B12 (cobalamin) is a water-soluble substance made out of a corrin ring, which contains a tetra-pyrrole ring and a cobalt element in the centre. Vitamin B12 is the only vitamin whose synthesis is possible only in the bacterial cells. Cobalamin is known for its positive influence on the nervous and cardiovascular systems. Vitamin B12, in form of adenosylcobalamin, is involved in energy transformations in the body system and in the conversion of methylmalonyl-CoA into succinyl-CoA.
Causes and consequences of vitamin B12 deficiency
Cobalamin deficiency negatively affects neural transmission, increases DNA vulnerability to damage and can lead to the wide spectrum of neurological symptoms, such as paraesthesia, impaired coordination, skin numbness, mood swings, memory problems, depression and impaired concentration.
Moreover, it is also associated with reduced synthesis of an enzyme involved in the conversion of homocysteine to methionine, which increases the risk of cardiovascular diseases (infarction, venous thrombosis). Vitamin B12 deficiency impairs hematopoietic processes, which can result in pernicious anaemia.
Causes for vitamin B12 deficiency include mainly impaired cobalamin absorption, excessive growth of bacterial flora, intestinal diseases and intestine resection. Increased demand for this vitamin is observed in case of overproduction of hydrochloric acid, atrophic gastritis, parasites and bacteria (H. pylori) as well as using particular drugs (proton pump inhibitors).
Better protection of the circulatory system
Vitamin B12 shows cardioprotective properties and supports the proper functioning of the circulatory system. Homocysteine is an amino acid whose excess in the body system increases the risk of cardiovascular diseases. Vitamin B12 is a cofactor for methionine synthase, the core enzyme involved in homocysteine transformation into methionine, which is why it can reduce homocysteine level in blood serum.
Positive influence on the hematopoietic system
Vitamin B12 is essential for the proper conduction of haematopoiesis. The vitamin is absorbed in the final part of the ileum, with participation of the Castle’s factor (an internal factor) which is released by the gastric parietal cells. From the combination of vitamin B12 with the internal factor results a haematopoiesis factor which is involved in formation of blood cells, erythrocytes, DNA and RNA in the erythroblasts.
Support for mental health
Vitamin B12 is essential for the maintenance of the nervous system integrity. It is involved in formation of myelin sheath and neurotransmitter production as well as plays an important role in the maintenance of stability of human genome.
Higher homocysteine level can negatively affect not only the circulatory system but also the nervous system. It has been demonstrated that hyperhomocysteinemia can be associated with an increased risk of dementia disorders (especially Alzheimer’s disease) and depression. Moreover, in elderly psychiatric patients, vitamin B12 deficiencies are quite common, and their symptoms include memory problems, depression, hypomania and personality changes. What is interesting, dysfunctions of the nervous system can be the only visible symptoms of vitamin B12 deficiency.
To sum it all up, Seeking Health, Adeno B12 is a dietary supplement which can complement even deep deficiencies of vitamin B12. The product is recommended especially for people exposed to the increased risk of B12 hypovitaminoses – vegans, vegetarians, elderly people (after the age of 50) and people after intestine resection.
Vitamin B12 supplementation is especially important in case of chronic deficiencies. Short B12 deficiencies are less dangerous, however they can reduce body system efficiency.
The optimal dose of vitamin B12 depends on the individual demands of the organism. Even high doses are safe, however they are rather intended for people exposed to increased risk of deficiencies and in case of homocysteine reduction.
Seeking Health is a brand which makes sure that the products it produces are characterized by high quality and purity, therefore the majority of their products is free from magnesium stearate, allergens and GMO.
This brand is directed at fighting the causes and not the symptoms, therefore the aim of the company is primarily to help in ensuring optimal work of the digestive system, among others by launching on the market high-class products supporting digestion and regenerating and nourishing the intestines, which consequently improves bioavailability of the substances beneficial to health and increases organism’s resistance to the effect of toxins coming from external environment.
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|per 1 lozenge||amount||%DV|
|Vitamin B12 (as adenosylcobalamin)||3000 mcg||125,000%|
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Adenosylcobalamin - a biologically active form of vitamin B12, which similarly to its methylated form does not need to undergo additional biochemical transformations in order to enter metabolic pathways in the human organism.
Apart from the best assimilability, adenosylcobalamin is distinguished from other forms of vitamin B12 by its high affinity for regeneration of nervous tissue. It is indicated that this form of cobalamin is engaged in the production of myelin sheaths with key meaning for proper neurotransmission. Apart from this, vitamin B12 is conducive to maintaining optimal functionality of the nervous system, being conducive to the synthesis of neurotransmitters.
Vitamin B12 is also an incredibly important regulator of methylation process, thanks to which its supplementation positively influences metabolism of the whole organism. It is a coenzyme in the conversion reactions of homocysteine to methionine as well as methylmalonyl-CoA to succinyl-CoA. Because of the first reaction, proper supply of vitamin B12 is also conducive to maintaining high concentrations of S-adenosylmethionine, thanks to which it positively influences mental functions.
Moreover, vitamin B12 is a key regulatory factor, taking part in erythropoiesis, i.e. the process of forming red cells. Its improper supply may be the cause of the development of the so-called vitamin B12 deficiency anemia.
Supplementation with vitamin B12 should be considered especially be people on vegetable diets and those who take drugs from the group of proton-pump inhibitors (PPIs) and metformin.
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