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Doctor's Best Best Curcumin C3 Complex is a dietary supplement whose single capsule contains 1000 mg of a standardized and concentrated turmeric extract and 5 mg of the black pepper extract. Curcumin is known for its anti-inflammatory, anticancer and antioxidant properties. Moreover, the presence of piperine helps to increase the bioavailability of the product.
Curcumin is a yellow dye which is present in curcuma and ginger. It belongs to the antioxidants from the family of polyphenols. This compound has been popular for more than 2,500 years. Already the ancient Ayurvedic texts (Ayurveda is an Indian system of medicine) have reported its numerous advantages. In the traditional medicine, it is used in the treatment of numerous diseases, such as: asthma, cough, allergies, jaundice, diarrhea, nervous system disorders, anorexia, wounds caused by diabetes, sprains and post-traumatic oedema. However, it is clear that only the modern medicine allowed us to benefit from numerous pro-health advantages of this unique compound.
Curcumin C3 Complex® is obtained from the dried rhizomes of Curcuma longa and it is standardized to a minimum 95% content of curcuminoids. The standardization of herbal remedies is necessary in order to evaluate the quality of the products on the basis of the concentration of the active substances. The name “C3 Complex®” refers to the three main chemical compounds which are contained in the product: curcumin, dimethoxy curcumin and bis-dimethoxy curcumin.
This is the main health promoting effect which results from the curcumins consumption, which leads to the neutralization of very unstable molecules (free radicals) which threaten the integrity of the cell structure.
The research conducted on cell cultures of human skin demonstrated the protective properties of curcuminoids from the influence of free radicals. Moreover, the study provides information that the combination of the three main representatives may amplify the effect because of the synergistic action.
The experiments on rats, which were exposed to neurotoxins and which were consuming curcumin, demonstrated that this compound can have an influence on the protection of the structure of the brain molecules and the promotion of glutathione levels – the main antioxidant which is present in the human body system.
Curcumin has a very strong inhibitory influence on the activation of macrophages and their recruitment to the place of inflammation. Moreover, it can reduce inflammation thanks to various mechanisms, among which the most famous is the inhibition of TNF-alpha factor, which induces the production of cytokines and inflammatory process.
Other possibilities to block inflammatory processes are: limiting the ability of immune cells to move into the place of inflammation and the reduction of development of the already existing inflammation by reducing the activity of inflammatory enzymes.
In 8-month-long pilot studies among people who suffered from rheumatoid arthritis of the knee joints, the researchers noted that general disease symptoms decreased by 41% in comparison to their initial number. Also decreases in pain and stiffness as well as an improvement of their functions have been observed. The test subjects consumed daily 200 mg of curcuminoids, which contained 75% of curcumins.
The anti-cancer properties of curcumin are attributer to its inhibiting influence on NF-kB proteins, which can affects the transcriptions and genetic coding when they are active. Normally, TNF-alpha (proinflammatory factor) positively influences the activity of NF-kB protein, which causes the cells growth and inflammations as well as enables the cells to survive.
Curcumin may inhibit the interactions between those two molecules by reducing the activity of F-kB without reducing TNF-alpha. It can also have an influence on the death and the deactivation of the proteins which contribute to the formation of cancer cells.
Currently, a research is conducted which pays attention to the possible chemopreventive properties of curcumins. Such an action of the curcumins should stop or slow down the carcinogenesis or it can reverse the already existing changes. Moreover, the population-based observation provides us with information that, for instance, Hindus, who consume large quantities of turmeric (1–2 g per day), are less prone to particular cancers than the inhabitants of the Western countries.
Bioperine® is a standardized black pepper extract which is a source of piperine. In the studies, it has been proven that it affects the bioavailability of nutrients (vitamins, minerals, plant substances) by increasing the secretion of digestive juices and slowing down the emptying of the stomach and intestines. Thanks to that, the all consumed food ingredients can be potentially longer exposed to the uptake and absorption.
Piperine is also an inhibitor of glucuronidation process in the liver. The process consists of attaching the molecule of glucuronic acid to the active substance (a medicine or other active substances), which should signal its excretion from the body system. The process prevents the accumulation of excessive amount of active substances which are present in dietary supplements and medicines. The consumption of piperine may decrease the excretion of certain substances and, at the same time, increase their bioavailability. Such substances are curcuminoids.
To sum it all up, Doctor's Best Best Curcumin C3 Complex is a dietary supplement with a wide range of prohealth properties, which are mainly a result of the presence of strong antioxidants (because, as it is commonly known, the free radicals are responsible for numerous diseases).
It is recommended in the anticancer prevention and among people who suffer from chronic inflammations (rheumatoid arthritis, osteoarthritis). Therapeutic doses may be used for a long period of time, because they do not cause any side effects.
Tablets: 1 tablet daily with a meal.
Capsules: 2 capsules daily with a meal.
Physician-founded in 1990, Doctor’s Best is a science-based nutritional supplement company, offering more than 200 products, made primarily with branded ingredients that are thoroughly researched, manufactured to the highest quality standards, and rigorously tested every step of the way—from raw materials to finished product. We use only cGMP-certified manufacturing facilities. Doctor’s Best is committed to transparency through education and communication and strives to be crystal clear in what we offer, why and how we offer it.
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