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Hepatica Curcumin C3 Complex is a diet supplement containing patented, concentrated turmeric extract which is a source of active curcuminoids - curcumin, demethoxycurkumin and bisdemetoxycurcumin that exhibit anti-inflammatory, analgesic and antineoplastic activity. The recommended daily dose supplies the organism with the amount of active substances equal to 13 spoons of turmeric! This product contains 90 vegetable capsules, suitable for vegetarians and vegans.
Curcumin is a polyphenolic compound that belongs to curcuminoids group. It is an intensive yellow dye present in turmeric (Curcuma longa), a plant known from millennia in holistic medicine as a versatile analgesic and antiseptic agent, in treatment of digestive system ailments, different kind of infections and skin disorders.
Currently, the biological activity of curcumin has been confirmed in many scientific studies. This substance has unique properties and because of them it can be a valuable preventive and healing agent for many civilization diseases.
Curcumin exhibits a strong anti-inflammatory and antioxidant activity, comparable to vitamin C and E. Oxidative stress, resulting from the excess of free oxygen radicals, can lead to damage of DNA, proteins, lipids and carbohydrates that build cell structures and to homeostasis disorders. Curcumin is a "sweeper" of free oxygen radicals, moreover, it has been shown in an animal model to inhibit peroxidation of membrane lipids. Curcumin can also affect the activation of genes responsible for coding antioxidant enzymes such as glutathione peroxidase or glutathione S-transferase, strengthening the natural antioxidant organism barrier.
Curcumin has anti-inflammatory and analgesic properties. Oxidative stress is connected with the formation of inflammation in the organism. Free oxygen radicals intensify the inflammatory reaction that leads to further production increase of reactive oxygen species. Curcumin displays multidirectional anti-inflammatory activity. It inhibits the activation of the NF-кB factor involved in the regulation of genes coding proinflammatory cytokines; reduces the production of TNF-α, IL-1, IL-6 and IL-8; reduces the production of cyclooxygenase 2 (COX-2) and lipoxygenase (5-LOX). The effect on COX-2 and 5-LOX determines the analgesic properties of curcumin.
In light of the above facts, curcumin is a potential candidate to be a drug for the inflammation based diseases. To these diseases belong, among others, the following: cardiovascular and neurodegenerative diseases, diabetes, RA and cancer. Up to this point, several hundred papers have been published (including clinical trials) that show the efficacy of curcumin in the reduction of: cognitive disorders; inflammation in the brain; beta-amyloid accumulation (as observed in Alzheimer's disease); inhibition of vascular degeneration; decrease in hyperglycaemia and improvement in lipid profile. Most of these tests have been performed on animals.
The research has confirmed antineoplastic and chemopreventive properties of curcumin. Changes in the genetic material of cells, e.g. induced by DNA mutations are considered as a basis for the tumor development. Curcumin has a chemopreventive effect against many types of tumors. In animal studies, curcumin reduced the formation of skin, liver and lung tumors after the exposition to carcinogens. The best established, however, is its preventive activity against gastrointestinal cancer. The antineoplastic activity of curcumin is mainly based on inhibiting the proliferation and inducing the apoptosis of tumor cells.
Demethoxycurkumin and bis-dimethoxy-curcumin are natural derivatives of curcumin, that have different number of methoxy groups in the molecule. They exhibit similar activity to curcumin.
To sum up, Hepatica Curcumin C3 Complex is a formulation of many pro-health properties. Concentrated, sound portion of the extract enables to enjoy the benefits of curcumin, that are difficult to obtain just form eating turmeric and curry. This product is recommended as a prophylaxis of civilization diseases; as a support for the digestive system; for the reduction of inflammation, improvement of insulin sensitivity and lipid profile; or after the consultation with a doctor – as a supplement in inflammatory diseases.
Curcumin and its derivatives have relatively low bioavailability, due to their hydrophobic character. It can be increased by the addition of piperine and fat. Therefore, it is best to take the product together with a meal containing fats and black pepper.
Hepatica is a young Polish producer dealing with the highest-class natural products. Its specialty is a range of plant preparations, devoid of unnecessary supporting substances. The quality of each of them results from proper selection of materials, high content of active substances, the dose adjusted to the needs and form of a given dietary supplement. The heart of the company is its founder, a renowned physiotherapist and co-founder of Nature Laboratory, SławekRasiński, who derives his inspiration and knowledge from around the World. Numerous travels and acquaintances with doctors and herbalists from all continents fruit, changing in dozens of unusual, effective and also often innovative preparations, on which a large board of analysis specialists work in the best prepared laboratories.
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Turmeric (Curcuma longa) is a plant of Asian, with the ginger family with a strong odour, contains curcumin, used as a dye (orange-yellow) for the food, e.g. rice, a spicy and acrid taste, soluble in fat and alcohols (water insoluble) . The raw material is the rhizome of turmeric, also containing an essential oil. It is used for prophylactic treatment because of its anti-inflammatory, antioxidant, antipyretic and cholagogic properties. Significantly increases thermogenesis, enhancing fat reduction. Its effects in the treatment of cancer (certain destroys cancer cells) have been proven. In the supplement it is available as a component of fat burners and supplements which improve the work of cartilage and joint tissue.
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