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Jarrow Formulas Vitamin D3 is a dietary supplement which contains vitamin D in form of cholecalciferol. One capsule contains up to 2,500 IU of vitamin D3, which is an optimal dose effectively protecting the nervous system from deficiencies.
The product is recommended within the prevention of vitamin D3 deficiencies. The deficiencies are particularly common in people living in non-sunny regions (UVB radiation is essential for the natural production of vitamin D3 in the body system), elderly and obese people. The supplementation is also recommended for people complaining about weak bones and immunity problems.
Vitamin D is an umbrella term for a group of chemical compounds of similar structure and biological activity. Because of its functions, it is often referred to as a prohormone. The human body system is able to synthesize vitamin D, but UVB radiation is necessary for this process. In supplementation, vitamin D is often used in form of cholecalciferol, the so called vitamin D3. It is oil-soluble and can accumulate in the organism. In the body system it has pleiotropic effects.
Influence on the skeletal system
The best known function of vitamin D3 is regulation of calcium/phosphorous management. It is essential for the proper absorption of calcium. It affects osteocalcin, a basic protein of bones, and calbindin, responsible for binding calcium. Thanks to that vitamin D3 contributes to the maintenance of the proper bone mineralization, health, elasticity and strength.
Too low level of vitamin D3 is often associated with osteomalacia. It is a dangerous disease causing weakening and demineralization of bones and muscle tissue degradation. Complementing the deficiencies not only prevents disease development but can even reverse the whole process.
Vitamin D3 modulates the immune system functions. It reduces its hyperactivity, so that it effectively protects from autoimmune diseases. It suppresses inflammations by reducing proinflammatory cytokines levels and raising anti-inflammatory cytokines levels.
Vitamin D3 contributes to the activation of lymphocytes T, which play a crucial role in the immune system. It also promotes cathelicidine synthesis, a peptide present in the human body system which acts as a natural antibiotic. This is why supplementation with vitamin D3 is recommended as a preventative element during the flu season.
Prevention of cardiovascular diseases
Vitamin D3 reduces the risk of cardiovascular diseases. It prevents hypertension thanks to the reduction in the activity of RAA system (renin–angiotensin–aldosterone system). It has a positive influence on smooth muscles and vascular endothelial. Vitamin D3 deficiencies are often associated with the very dangerous medical condition, left ventricular hypertrophy.
Vitamin D3 contributes to the increase in the level of intracellular glutathione, so that it protects nerve cells from the neurotoxic effects of oxidation. It slows down the associated with age changes in neurons density in the area of hippocampus, which increase the risk of dementia and memory problems.
The researchers have proven that high level of vitamin D3 protects brain cells from dying because of stroke, which significantly reduces its negative consequences.
Numerous studies have demonstrated that too low level of vitamin D3 in the body system correlates with the frequency of cognitive disorders, Alzheimer’s and Parkinson’s diseases. This is probably associated with the influence of vitamin D3 on the production of neurotransmitters, particularly dopamine.
Prevention of cancers
Vitamin D3 has a slight anticancer potential. It reduces the risk of 17 different types of cancers. It inhibits the pathogenic proliferation of cells and protects the genome from accumulation of mutations, which are the main cause of cancer development. It increases the process of cell differentiation, and thanks to apoptosis stimulation it prevents the spread of cancer.
Improvement in insulin sensitivity
Vitamin D3 can support the treatment of diabetes and it is an important factor of its prevention. It positively affects the functioning of beta cells, increases insulin sensitivity and improves its secretion.
Benefits for athletes
Vitamin D3 can bring some benefits for physically active people – complementing the deficiencies increases muscle strength. Numerous tests have demonstrated that trainings of people with the proper vitamin D3 level are much more efficient than trainings of people with avitaminosis.
Some research suggests that vitamin D3 raises testosterone levels, mainly due to the reduction in globulin level, which is responsible for binding sex hormones.
To sum it all up, Vitamin D3 is the best way to solve the problem of vitamin D3 deficiencies. The product is especially recommended for people avoiding sun, by whom the natural synthesis of vitamin D3 has been inhibited. Used regularly, it supports the body system in many aspects and reduces the risk of numerous diseases, ranging from slight infections to dangerous cancers. The properly chosen form and dose of the vitamin guarantee perfect bioavailability and highest effectiveness.
The standard dose protecting from the deficiencies in adults with the proper vitamin D3 level amounts for 1,000–2,000 IU a day. Therapeutic doses can be higher, up to 10,000 IU in elderly people and during the autumn/winter period, when the natural synthesis of vitamin D3 is inhibited due to the lack of sunlight.
Vitamin D3 is oil-soluble, which is why it should be taken with a meal containing a good source of fat to ensure optimal absorption.
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Vitamin D belongs to fat soluble vitamins, occurs in three forms: calciferol (vitamin D1) ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), it is formed under the action of sunlight for at least 15 minutes per day. In the absence of sunlight it should be administered in the diet in the form of fish oil (Vitamin A + D3) and fish oils. It is responsible for the absorption of calcium and phosphorus. It is the building substance of bone tissue particularly necessary during pregnancy, childhood, and for athletes. It is a component of dietary supplements and nutrients among competetive athletes. Deficiency of vitamin D causes children growth inhibition, and rickets.
For adults - deficiency causes osteomalacia.
Excess of vitamin D causes headaches, alopecia, nausea, drowsiness, blurred vision, pain in the long bones, the deposition of calcium deposits.
Dosage: 400 IU units during the day.
Cholecalciferol, or vitamin D3, is an organic chemical that belongs to the family of D vitamins. It is naturally found in fatty fish, fish oil, egg yolks, milk and dairy products. It is also synthesized in the human body. It is formed from 7-dehydrocholesterol present in the keratinocytes of the spinous and the basal layers of the epidermis, and a pre-requisite for initiating this process is the action of 290-315 nm wavelength UVB radiation on the skin.
Cholecalciferol is a biologically inactive compound. In the body, it undergoes enzymatic hydroxylation – first in the liver, with the participation of 25-hydroxylase, when calcidiol is formed and secondly in the kidneys, where under the influence of 1-α-hydroxylase, calcidiol is converted into the final active form – calcitriol.
The most important role of vitamin D3 in the body is the regulation of calcium-phosphate metabolism, which directly affects normal skeletal mineralization. In addition, it is involved in cell proliferation and differentiation, insulin secretion, as well as in some functions of the nervous, endocrine and immune systems.
Cholecalciferol is the most popular form of vitamin D used in dietary supplements. Studies show that supplementation with vitamin D in this form most effectively and rapidly raises the level of 25 (OH) D3 – a metabolite that is a marker of the level of vitamin D in the body.
Dosage: according to RDI standards for individual age groups.
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