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Now Foods Vitamin D-3 400 IU is a dietary supplement containing vitamin D3 in the form of cholecalciferol obtained from lanolin. Vitamin D3 was suspended in high-quality extra virgin olive oil, which increases its stability and assimilability. One capsule contains 400 IU (10 mcg) of vitamin D3.
Vitamin D3 is a compound soluble in fats with steroid structure. Partial, but insufficient need for this essential vitamin is covered by skin synthesis. Vitamin D3 present in skin under the influence of UV-B radiation is converted to vitamin D3 and then in the liver and kidneys to the active calcidiol and calcitriol.
Calcitriol - an active form of vitamin D3 works by means of nuclear receptors VDR (vitamin D receptor), located in cells of almost all organs - bones, intestinal epithelium, heart, brain or pancreas. Activation of these receptors influences the expression of ca. 200 genes. Moreover, calcitriol, by acting through membrane receptors, influences the activation of kinases, proteases and the synthesis of prostaglandins.
Vitamin D3 regulates calcium-phosphorus balance, essential for proper mineralization of bones and calcium absorption. It has protective influence on cells of osseous and cartilaginous tissue. Vitamin D3 deficiency in children results in rickets and improper bone mineralization and in adults it leads to bone pain and osteoporosis.
Vitamin D3 regulates the activity of the immune system of the organism. Activation of neutrophils of VDR receptors located in lymphocytes T and B influences decreasing inflammations. Vitamin D3 stimulates maturation of monocytes to macrophages, responsible for phagocytosis of pathogens and chemotaxis. Deficiency of this vitamin, by causing the decrease of the activity of acid phosphatase disturbs differentiation of monocytes, which consequently leads to weakening the organism’s immunity. Moreover, vitamin D3 deficiency is related to numerous autoimmune and infectious diseases.
An important direction of therapies of autoimmune diseases is reduction of inflammations in the organism. Vitamin D3 may decrease inflammation caused by the intensified synthesis of the so-called tumor necrosis factor in rheumatoid arthritis. It may be also helpful in the therapy of psoriasis.
Vitamin D3 causes the increase of glutathione level in the organism. Glutathione (GSH) is a tripeptide appearing in the highest amounts in the liver - a filter which protects the organism from the activity of toxins. Glutathione is a strong antioxidant, which protects the organism from oxidative stress and biochemical reactions with its participation are mainly detoxifying, enabling the elimination of toxic substances from the organism. Decreasing oxidative stress is important from the neuro- and cardioprotective point of view and from the point of view of degenerative and cardiovascular system diseases.
To sum up, Now Foods Vitamin D-3 400 IU is a preparation recommended for longer supplementation, especially in deficiencies of vitamin D3, in order to ensure proper mineralization of bones and teeth in the periods of fatigue and in order to improve well-being and general state of health.
According to the data complied by EFSA regarding the dosing of vitamin D, its daily safe dose for adults is 4000 IU per day, while higher values (even up to 10000 IU per day) are recommended it case of i.a. pathological obesity and absorption disorders.
Vitamin D is a compound soluble in fats, therefore in order to ensure the best absorption, it should be taken with a meal containing fat.
Now Foods is a company with years of experience in the industry that offers a wide range of nutrients and dietary supplements. Brand is known for its high-quality products designed for hair and nails and supplements supporting the immune system. The offer includes the antioxidant supplements, antibacterial supplements, reducing appetite supplements, products supporting the reduction of body fat and improving digestion. All products are made from natural ingredients.
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Vitamin D belongs to fat soluble vitamins, occurs in three forms: calciferol (vitamin D1) ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), it is formed under the action of sunlight for at least 15 minutes per day. In the absence of sunlight it should be administered in the diet in the form of fish oil (Vitamin A + D3) and fish oils. It is responsible for the absorption of calcium and phosphorus. It is the building substance of bone tissue particularly necessary during pregnancy, childhood, and for athletes. It is a component of dietary supplements and nutrients among competetive athletes. Deficiency of vitamin D causes children growth inhibition, and rickets.
For adults - deficiency causes osteomalacia.
Excess of vitamin D causes headaches, alopecia, nausea, drowsiness, blurred vision, pain in the long bones, the deposition of calcium deposits.
Dosage: 400 IU units during the day.
Cholecalciferol, or vitamin D3, is an organic chemical that belongs to the family of D vitamins. It is naturally found in fatty fish, fish oil, egg yolks, milk and dairy products. It is also synthesized in the human body. It is formed from 7-dehydrocholesterol present in the keratinocytes of the spinous and the basal layers of the epidermis, and a pre-requisite for initiating this process is the action of 290-315 nm wavelength UVB radiation on the skin.
Cholecalciferol is a biologically inactive compound. In the body, it undergoes enzymatic hydroxylation – first in the liver, with the participation of 25-hydroxylase, when calcidiol is formed and secondly in the kidneys, where under the influence of 1-α-hydroxylase, calcidiol is converted into the final active form – calcitriol.
The most important role of vitamin D3 in the body is the regulation of calcium-phosphate metabolism, which directly affects normal skeletal mineralization. In addition, it is involved in cell proliferation and differentiation, insulin secretion, as well as in some functions of the nervous, endocrine and immune systems.
Cholecalciferol is the most popular form of vitamin D used in dietary supplements. Studies show that supplementation with vitamin D in this form most effectively and rapidly raises the level of 25 (OH) D3 – a metabolite that is a marker of the level of vitamin D in the body.
Dosage: according to RDI standards for individual age groups.
Lanolin is obtained in the process of cleaning of raw sheep wool from the so-called wool fat, protecting it from getting wet and unbeneficial weather conditions.
Lanolin is commonly used for the production of ointments and creams with lubricating and softening effect, however, it also found application in the production of dietary supplements and more precisely vitamin D3.
In order to obtain vitamin D3 from lanolin, it undergoes cleaning and crystallization and then proper chemical processes, as a result of which 7-dehydrocholesterol is produced - a precursor of vitamin D3, the same which is produced in skin under the influence of UV radiation. 7-dehydrorocholesterol obtained from lanolin is then subjected to the above mentioned radiation, being transformed to vitamin D3.
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