• Vitamin K2 in the patented form of VitaMK7®
• The combination of vitamins with synergistic action
• Cardiovascular health
• A natural source of vitamin K2 MK-7
• Prevention of civilization diseases
• Reduction of inflammation
• Reduction of tiredness
• Positive effect on the mood
• Strengthening of the body’s immunity
• Proper muscle work
• Prevention of osteoporosis

Aliness Vitamin K2 MK-7 100 μg from Natto + D3 is a dietary supplement containing vitamin D3 and vitamin K2 MK-7 in the patented form of VitaMK7®, obtained through the fermentation process involving Bacillus subtillis natto bacteria cultures, developed by Gnosis. The product is intended to supplement the deficiencies of vitamins D3 and K2 and to support cardiovascular health and the musculoskeletal system.

Vitamin K2 is a group of compounds – menaquinones, which include various subtypes of MK, the most active of which is MK-7. One of the best sources of vitamin K2 MK-7 is natto – a Japanese dish made from fermented soybeans. VitaMK7®, produced in a patented process of bacterial fermentation with the participation of scientifically tested Bacillus subtillis natto strains, is one of the few sources of natural vitamin K2 with a documented action checked by EFSA (European Food Safety Authority).

Vitamin D3 belongs (along with vitamin K2) to the group of fat-soluble vitamins. The active metabolite of vitamin D3 – calcitriol – is a steroid hormone that regulates the calcium-phosphate balance of the body and the expression of genes through the effect on specific VDR nuclear receptors (vitamin D receptors). Vitamin D3 has a multi-directional, positive effect on the health and proper functioning of the skeletal, muscular, nervous and immune systems and plays an important role in the prevention of civilization diseases.

Musculoskeletal health
The most well-known function of vitamin D3 is the regulation of calcium-phosphate balance and maintenance of the systemic mineral homeostasis. Calcitriol increases the absorption of calcium from the intestines and inhibits its excretion in the urine. Too low concentration of this element in the blood results in an increased release of calcium from the bones.

Calcium has a number of extremely important physiological functions, including the involvement in hormonal regulation and neurotransmission; it is necessary for muscle contraction, plays a role of building material – it is necessary for the proper mineralization of the skeleton. Almost 99% of calcium in the bones is bound in the form of apatite.

In addition to the regulation of calcium-phosphate metabolism, vitamin D3 affects the metabolism of bone tissue, directly affecting individual populations of bone cells. By regulating gene expression, it plays an important role in osteogenesis, bone cell differentiation, maintenance of balance between resorption and bone formation, and synthesis of proteins by osteoblasts that are necessary for optimal bone mineralization.

Vitamin D3 affects the proper functioning of the muscles, as evidenced by the presence of VDR receptors in smooth and striated muscle cells. It positively influences the synthesis of muscle proteins and has anti-inflammatory properties, thanks to which it supports post-workout regeneration and may protect against injuries.

Synergism of the action of vitamins D3 and K2
Vitamins D and K cooperate in the regulation of calcium-phosphate metabolism and bone tissue metabolism. Figuratively speaking, vitamin D3 increases the absorption of calcium, while vitamin K2 allows transport of calcium to the bone, protecting against the undesirable deposition of this element, for example in the arteries (which poses a threat to the cardiovascular system) and joints.

Vitamin K2 affects the activity of osteocalcin, a bone matrix protein, which in its active form is able to incorporate calcium ions into the bone tissue. In addition, vitamin K2 stimulates the SXR receptors (steroid and xenobiotic receptor), thus contributing to the regulation of the expression of numerous genes encoding bone matrix proteins.

Common vitamin D deficiencies
Vitamin D3 is naturally produced from the 7-dehydrocholesterol present in the skin under the influence of UV-B radiation. Common deficiencies of this vitamin result from ineffective skin synthesis caused by insufficient exposure of inadequately large skin surface to the sun, the use of sunscreens, air pollution and geographical location, which prevents optimal sun exposure. Due to the numerous health consequences of long-term vitamin D3 deficiency, it should be supplemented with a high-quality preparation.

To sum up, Aliness Vitamin K2 MK-7 100 μg from Natto + D3 is a preparation recommended for regular supplementation to prevent deficiencies of vitamins D3 and K2, support musculoskeletal and cardiovascular health, strengthen immunity, in autumn and winter, for elderly people and athletes, and to prevent civilization diseases.