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|Servings: 120 caps.|
In the last batches of Apollo's Hegemony products, another glue was used for lids under the caps. The glue is weaker than previously used, this is why the lid often stays inside the cap when unscrewing the bottle. This does not affect the quality of products because during storage the lid adheres to the bottle and protects its contents.
What distinguishes Apollos Hegemony from other products?
The product Apollos Hegemony Vitamin D3 with K2 consists of the following components:
Vitamin D3 (cholecalciferol) – called a sunshine vitamin, is a compound with a steroid structure traditionally classified to the vitamins, but in the human body it plays the role of a prohormone. It is synthesized from cholesterol in the skin under the influence of sunlight, UV-B. Then in the liver and kidneys, as a result of metabolic reactions, it gets transformed into calcitriol – the active form of vitamin D, a hormone controlling the calcium-phosphate economy in the body. In many tissues and cells it connects to its nuclear receptor – VDR, while controlling more than 200 genes. He interacts with vitamin A, vitamin K2 and calcium.
Vitamin K2 (menaquinone) – a group of compounds – menaquinons – effecting on different biological reactions in the body, especially on the economy of calcium, maintaining proper bone health and the cardiovascular system. A unique form is menaquinone-7 (vitamin K2 MK-7), naturally occuring in fermented soybeans (natto), which exhibits the longest action in the body, lasting up to 72 hours, and excellent absorbability as well.
The demand for vitamin D and deficiency causes
Vitamin D deficiencies are common. According to the data obtained in 2005-2006 up to 41.6% of Americans have a deficiency of vitamin D. It should be remembered that in those years it was not thought yet that this relationship plays such an important biological role in every human cell.
It grows constantly the number of scientists who raise an optimal health threshold level of vitamin D in the blood. Time and again coming new information about its unusual properties, because at the moment a real need for this vitamin is not known to us. However, one we can be sure – we need more of it than we thought.
Long-term vitamin D deficiencies have tragic consequences for human health. Apart from the symptoms as a disease of the skeletal system, researchers have shown a link between a low level of vitamin D, and the occurrence of many terrible diseases such as multiple sclerosis (MS), cancer, autoimmune diseases, atherosclerosis, diabetes, depression, infertility or Alzheimer's disease.
The main causes of the vitamin D deficiency are: no or limited exposure to sunlight, poor diet (too low intake of oily fish), season, air pollution and abuse of creams with UV filters. Remember also that it should be noted that the need for vitamin D increases in various disease states, likewise with age.
Supplementation with vitamin D should be taken into account by people who have too little use of the gift of sunlight, and athletes who want to improve exercise capacity. In the autumn-winter period it is recommended to supplement vitamin D, which is essential to anyone.
The demand for vitamin K2 and deficiency causes
The history of vitamin K2 can be combined with the findings of the well-known, but also a controversial dentist – Weston Price. That dentist, in the early twentieth century, studied the relationship between a diet and dental diseases in different populations. On the basis of observations and researches, he discovered that people consuming industry unprocessed products with a high content of unidentified (then) component, they exhibited a better protection against tooth decay, as well as a lower incidence of chronic diseases. Later, the unidentified ingredient was called vitamin K2.
You should not identify vitamin K2 (menaquinone) with a well-known vitamin K1 (phylloquinone), which is common in many parts of many green plants and is involved in blood clotting. The first one is not enough in our diet.
As it turns out, in the diet of western countries there is a serious deficiencies of vitamin K2, particularly its long form, so MK-7 and MK-9, which is probably due to the small amount of fermented products in the diet and the negligence of the natural intestinal microflora, which should be a source of the vitamin.
Shorter acting form of vitamin K2, so MK-4, which is common in fatty animal products: eggs, dairy products, meat and liver. However, over the past 10-15 years a cholesterol phobia caused that people began to avoid fat-rich foods. It also heightened the disadvantage of the occurrence of shortages of menaquinons, and thus the deterioration of bone health, the emergence of osteoporosis and other bone diseases.
Apollos Hegemony Vitamin D3 with K2 supports the skeletal system
The activity of vitamin D results in increased absorption of calcium in the intestines and the decrease of urinary calcium excretion – interacting with parathyroid hormone (PTH) in the reabsorption of calcium, while reducing its level (parathyroid hormone).
A deficiency of vitamin D results in rickets (in children), bone loss, digestion disorders, osteomalacia, osteoporosis and adults results in bone pains.
Osteocalcin is a non-collagenous synthesized protein, primarily by osteoblasts (bone formation cells). Involved in the transport of calcium ions and binding it to the hydroxyapatite matrix – the mineral composed of calcium hydroxyphosphate, which is a mineral scaffold of connective tissue, which is responsible for the mechanical strength of bone.
However, osteocalcin shows its activities in respect of calcium ions, mainly in the form of a carboxylate, which is achieved only by the presence of Vitamin K2. Put it simpler, Vitamin K2 participates in the transport of calcium from the blood to the places where it is needed, especially to the bones.
Studies have confirmed the effectiveness of vitamin K2. It has been shown that, among other, it increases bone mineral density (BDM) in patients with hip fracture, while a deficiency of this vitamin can contribute to bone fragility.
Apollos Hegemony Vitamin D3 with K2 supports the immune system
Vitamin D exhibits immunomodulatory and indirectly antimicrobial properties – activates genes encoding antimicrobial peptides of the characteristics of natural antibiotics. It supports the innate immunity, while suppressing the adaptive immunity – which inhibits autoimmune reactions.
It also protects against mutations of the genes that underlie neoplastic transformation and progression of cancer. It is currently believed that vitamin D reduces the risk of up to 17 types of cancer.
Recent reports indicate that Vitamin K2 is an important point in the prevention of cancer as well as in their treatment. One theory explaining the mechanism of the antitumor activity is the induction of oxidative stress in cancer cells, thereby inhibiting their growth and sometimes results in the death of that cell. Thus, vitamin K2 in relation to the tumor cells is a pro-oxidant.
Apollos Hegemony Vitamin D3 with K2 supports the muscular system
Vitamin D, like testosterone, is a steroid, which activates a specific nuclear receptor in the muscle tissue stimulating genes, including those responsible for anabolic processes. While testosterone activates specific for it androgen receptor (AR), the vitamin D activates the proper receptor – known as Vitamin D receptor (VDR).
Vitamin D increases the protein synthesis directly as an anabolic hormone, while exhibiting anti-catabolic properties – it inhibits myostatin production and IGFBP (the protein binfong growth factor IGF-1).
Apollos Hegemony Vitamin D3 with K2 supports the nervous system
Vitamin D receptors are also found in the brain, and its deficiency may contribute to the development of depression, schizophrenia, Alzheimer's disease or lead to cognitive impairment.
It has been shown that vitamin D regenerate neurons, including myelin sheaths of nerve fibers, thereby preventing the formation and development of multiple sclerosis (MS).
There is also a link between vitamin D deficiency and disorders of sleep (insomnia) depression or neurosis motivated.
Apollos Hegemony Vitamin D3 with K2 supports the cardiovascular system
Vitamin D stimulates the production of prostacyclin – tissue hormones with anti-aggregation properties. Prostacyclin prevents platelets from sticking together and acts diastolic on the blood vessels reducing blood pressure.
Recently, there were also carried out studies in which the inhibitory effect of vitamin D on the activity of proteolytic enzymes was observed, which participate in pathological remodeling of the heart cells and blood vessels.
Vitamin K2 is not only to prevent osteoporosis, but as well as calcification or sclerosis and blood vessels hardening. It directs the excess of calcium found in the blood vessels to the right places for it, which prevents the formation and hardening of atherosclerotic plaques.
Apollos Hegemony Vitamin D3 with K2 supports the endocrine system
In one study, the supplementation with vitamin D after one year time resulted in a 30 percent increase of testosterone level of both total and free compared to placebo. Moreover, it has been shown that it enhances the action of testosterone and its derivatives on muscle mass, likewise stimulates the reprodaction of androgen receptors (AR).
Scientists have shown that the vitamin D supplementation in infancy reduces the risk of type 1 diabetes. The next studies have shown that it improves insulin secretion and glucose tolerance in patients with type 2 diabetes.
Up until recently, recommended dosage for vitamin D and maximal daily dosage were set on a much smaller level than now. The analysis of a lot of research shows that even the current recommended daily dosage is too restrictive. it's postulated to make the vitamin D dosage higher. This product has a higher dosage than a recommendations, but it's appropriate for scientific proof provided in the recent research. One portion is enough to cover the daily adult dosage. We don't recommend increasing the dose.
Apollo’s Hegemony is a manufacturer of dietary supplements whose composition is based on the latest scientific research and experience. The company is constantly expanding its range of products and taking care that they are of top quality.
It offers formulations which have multiple effects on the body and those with more targeted effects – e.g. boosting alertness and focus, increasing the tolerance to stress, promoting peaceful sleep and maintaining the health of the liver and adrenal glands.
Dietary supplements by Apollo’s Hegemony are effective owing to carefully selected composition which comprises the most potent forms and their precise doses. What is more, herbal supplements contain standardised extracts.
All products of this brand comply with good manufacturing practices (GMP) and their ingredients are vegan and vegetarian friendly.
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Rice Flour, Hypromellose (vege capsule).
The product has not been tested for substances banned by the World Anti-Doping Agency (WADA).
Lanolin is obtained in the process of cleaning of raw sheep wool from the so-called wool fat, protecting it from getting wet and unbeneficial weather conditions.
Lanolin is commonly used for the production of ointments and creams with lubricating and softening effect, however, it also found application in the production of dietary supplements and more precisely vitamin D3.
In order to obtain vitamin D3 from lanolin, it undergoes cleaning and crystallization and then proper chemical processes, as a result of which 7-dehydrocholesterol is produced - a precursor of vitamin D3, the same which is produced in skin under the influence of UV radiation. 7-dehydrorocholesterol obtained from lanolin is then subjected to the above mentioned radiation, being transformed to vitamin D3.
Vitamin D belongs to fat soluble vitamins, occurs in three forms: calciferol (vitamin D1) ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), it is formed under the action of sunlight for at least 15 minutes per day. In the absence of sunlight it should be administered in the diet in the form of fish oil (Vitamin A + D3) and fish oils. It is responsible for the absorption of calcium and phosphorus. It is the building substance of bone tissue particularly necessary during pregnancy, childhood, and for athletes. It is a component of dietary supplements and nutrients among competetive athletes. Deficiency of vitamin D causes children growth inhibition, and rickets.
For adults - deficiency causes osteomalacia.
Excess of vitamin D causes headaches, alopecia, nausea, drowsiness, blurred vision, pain in the long bones, the deposition of calcium deposits.
Dosage: 400 IU units during the day.
Cholecalciferol, or vitamin D3, is an organic chemical that belongs to the family of D vitamins. It is naturally found in fatty fish, fish oil, egg yolks, milk and dairy products. It is also synthesized in the human body. It is formed from 7-dehydrocholesterol present in the keratinocytes of the spinous and the basal layers of the epidermis, and a pre-requisite for initiating this process is the action of 290-315 nm wavelength UVB radiation on the skin.
Cholecalciferol is a biologically inactive compound. In the body, it undergoes enzymatic hydroxylation – first in the liver, with the participation of 25-hydroxylase, when calcidiol is formed and secondly in the kidneys, where under the influence of 1-α-hydroxylase, calcidiol is converted into the final active form – calcitriol.
The most important role of vitamin D3 in the body is the regulation of calcium-phosphate metabolism, which directly affects normal skeletal mineralization. In addition, it is involved in cell proliferation and differentiation, insulin secretion, as well as in some functions of the nervous, endocrine and immune systems.
Cholecalciferol is the most popular form of vitamin D used in dietary supplements. Studies show that supplementation with vitamin D in this form most effectively and rapidly raises the level of 25 (OH) D3 – a metabolite that is a marker of the level of vitamin D in the body.
Dosage: according to RDI standards for individual age groups.
What is Vitamin K2 MK-7?
Vitamin K2 MK-7 is a long-chain form of vitamin K2 (menaquinone) containing 7 isoprene residues in the side chain. It is a vitamin soluble in fats. It is usually applied to complement the supplementation with vitamin D in order to achieve the synergy of effect and reduce possible undesirable effects.
It exerts the strongest influence on bones and circulatory system. The most significant role of vitamin K2 MK-7 is the activation of osteocalcin – a hormone produced by bones, which among others takes part in transporting calcium to bones and teeth. Thanks to this, it increases mineral density of bones and limits the risk of storing calcium in soft tissues, such as blood vessels, reducing at the same time the probability of developing atherosclerosis.
Other health benefits are based on the possibility of testosterone level growth, thanks to stimulating Leydig cells in testicles and neuroprotective properties, protecting nervous system against degeneration and development of dementia.
Vitamin K2 MK-7 in monopreparations, preparations combined with vitamin D3 and vitamin complexes may be found in the offer of the shop muscle-zone.pl.
What is menaquinone-7?
Menaquinone-7 is a term used for long-chain form of vitamin K2, having seven isoprene residues in the side chain. Contrary to another popular form MK-4, it is not synthesized in tissues, however, it may be produced in the intestines by means of the conversion from vitamin K1 by intestinal bacteria.
It exhibits especially positive influence on the health of the circulatory system, especially by lowering the risk of atherosclerosis and heart attacks. It owes this effect mainly to osteocalcin, activated by vitamin K2. This hormone is responsible among others for the transport of calcium to bones, which counteracts its storage in soft tissues, decreasing at the same time the probability of blood vessel calcification and the creation of atherosclerotic plaques. K2 MK-7 also contributes to protecting the nervous system, securing neurons from excitotoxicity induced by excessive activity of glutamate and reducing the consequences of excessively low level of glutathione.
Vitamin K2 in the form of menaquinone-7 is a very popular additive to supplements with vitamin D3, due to the synergy of effects and reducing potential negative effects of applying higher doses of cholecalciferol.
Menaquinone-7 may be found both in monopreparations and complex supplements in the offer of muscle-zone.pl.