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Jarrow Formulas B-Right is an exclusive dietary supplement containing the most absorbable, bioavailable and metabolically active form of vitamin B. The product stands out from other similar products due to the content of methylcobalamin (B12), 5-MTHF, pantethine and P-5-P. Also, for even greater efficiency, there are double forms of vitamin B6, B3 and pantothenic acid (B5) in it. This product perfectly streamlines methylation, supports the nervous system, lowers a homocysteine level and preventing cardiovascular diseases.
B vitamins are a group of organic nutrients, essential in small quantities for a variety of biochemical functions. In general, these compounds are not synthesized by the organism, and therefore, must be provided with food. They belong to water-soluble vitamins, that play a role of enzyme cofactors (as co-enzymes or prosthetic groups), ie. necessary part of enzymes involved in a normal course of certain biochemical reactions in the body.
Deficiency of only one vitamin B is rare, because the incorrect composition of a diet is the most common cause of multiple deficiencies. However, the deficiency of one vitamin may cause characteristic clinical symptoms.
And so, a deficiency of thiamine (vitamin B1) causes the beri-beri disease, a deficiency of riboflavin (vitamin B2) – the inflammation of the corners of the mouth and tongue, deficiency of niacin (vitamin B3) – symptoms of pellagra, a deficiency of vitamin B12 (cobalamin) – megaloblastic and pernicious ischemia, a deficiency of folic acid – also megaloblastic anemia.
Jarrow Formulas B-Right includes the following components:
Folate (pteroylpolglutamate) – also known as a folic acid, vitamin B9 or B11, which is synthesized in the body by the intestinal bacteria; It is the bioactive form of tetrahydrofolate (THF), which acts as a coenzyme in the reactions of the transfer of one-carbon active groups (methyl, formyl, methylene) – it is a donor of these units. It works with vitamin B12 in many physiological processes.
It is present food in different forms of folate, that may include up to seven additional glutamate residues, which are linked by gamma-peptide. The performance of individual folate absorption is different, which is why experts express it with folate equivalents.
5-Formyl-THF complex is a more stable form of folate, and therefore, is used in medicine as a drug known as leucovorin or a folinic acid. However, the main factor of introducing a one-carbon groups to substituted folates is 5,10-methylene-THF, formed by the reaction of glycine, serine and choline THF. THF derivatives play a huge role in many synthesis reactions where the products are not limited to: DNA, glycine, serine, methionine, purines and formylmethionine.
The product Jarrow Formulas B-Right contains special active form of folate (5-methyl-tetrahydrofolate), which is the main source of tetrahydrofolate tissues. It restores the correct processes of methylation in the body, and plays a special role in lowering the level of homocysteine, which is crucial for the cardiovascular system health.
What is homocysteine?
Homocysteine is a sulfuric amino acid, arising in human as a result of demethylation of the amino acid methionine. Currently, it is considered as an independent risk factor for atherosclerosis, coronary heart disease, heart attacks and thrombotic changes.
An increased homocysteine concentration is a significant risk for the development of atherosclerosis, thrombotic changes and hypertension. These changes are caused by impaired synthesis of 5-MTHF by methylenetetrahydrofolate reductase, which develops functional folate deficiency, leading to impaired re-methylation of homocysteine to methionine.
Some studies demonstrated that approximately 30% of the adult population in Poland has too high (abnormal) blood level of homocysteine, which is called hyperhomocysteinemia. The most common cause for this is the lack of vitamin B12, B6 and folic acid. Proper supplementation with these vitamins reduces a harmful homocysteine level, while protecting the cardiovascular system against complications.
5-MTHF goes into action
S-Adenosylmethionine (SAM-e), as a methyl donor, it creates homocysteine forms, which may be re-methylation only by the reaction of 5-MTHF. This latter reaction is catalysed by methionine synthase, an enzyme which is dependent on vitamin B12. The result of the above reaction is the production of methionine, which reduces the level of homocysteine in the body, which prevents the development of cardiovascular diseases.
Folic acid as a hematopoietic factor
Folic acid also belongs to hematopoietic factors which determine the proper course of erythropoiesis, ie. the process of proliferation and differentiation of erythrocytes (red blood cells), from stem cells in bone marrow of flat bones and the roots of long bones. Its deficiency in the body leads to megaloblastic anemia, resulting from an abnormal DNA synthesis, which results in the disorder of blood cell maturation. In addition, there may be disturbances of the central nervous system, which also needs this vitamin to function properly.
Vitamin B12 (cobalamin) – a common name for a group of cobalamins (cyanocobalamin, hydroxocobalamin, methylcobalamin, adenosylcobalamin) so corrinoids – compounds containing cobalt in the corrin ring – showing biological activity of vitamins. It is synthesized by the intestinal microflora, but the major source are animal foods, because the plants do not produce this vitamin. This shows that strict vegans are a risk group for the development of B12 deficiencies.
The influence of B12 (methylcobalamin!) on the level of homocysteine:
Particularly important enzyme vitamin B12-dependent is methionine synthase (homocysteine methyltransferase in other words), which catalyzes the conversion of (re-methylation) of homocysteine to methionine, which takes place during the reaction of mehtylotetrahydrofolian (5-MTHF).
Deficiency of vitamin B12, as a cofactor (as methylcobalamin!) is a cause of impaired methionine synthase activity, leading to accumulation of excess homocysteine (hyperhomocysteinemia) and so called "folate trap" – a functional folate deficiency as a result of shortage of methylcobalamin.
Vitamin B12 (methylcobalamin!) on a erythrocytes level and anemia:
Pernicious anemia arises when due to a lack of methylcobalamin disturbed is metabolism of a folic acid and then erythropoiesis, resulting in a release of immeture red blood precursors from the bone marrow into the blood (megaloblastic anemia). The most common cause of pernicious anemia is impaired absorption of vitamin B12 from the gastrointestinal tract.
Vitamin B12 deficiency causes diseases
Vitamin B12 deficiency manifests itself as a complex syndrome, whose main symptoms are those neurological, hematologic, and psychiatric. At the core of biochemical syndrome is a disorder of methionine metabolism, caused by the absence of the cofactor (which is cobalamin) methionine synthetase enzyme. If left untreated, it is life-threatening condition.
The cause of B12 deficiency may be a vegan diet or impaired absorption of this compound, caused, inter alia, by the use of drugs for heartburn – proton pump inhibitors (PPI).
Jarrow Formulas B-Right contains a bioactive form of vitamin B12 in the form of methylcobalamin(!), which directly activates the process of lowering a homocysteine level in the body, restores the correct processes of methylation in the body, and prevents dysfunctional deficiency of a folic acid to prevent pernicious and megaloblastic anemia.
Vitamin B6 (Pyridoxine) – is present in the six forms as a result of enzymatic reactions are converted into pyridoxal phosphate (the biologically active form of vitamin B6), which acts as a coenzyme or prosthetic group of enzymes, responsible for the metabolism of amino acids (transaminases and decarboxylases).
Vitamin B6 is required for the synthesis of neurotransmitters (dopamine, serotonin and norepinephrine), hemoglobin (red blood pigment), and it facilitates the absorption of magnesium from the gastrointestinal tract. It relieves the symptoms of premenstrual syndrome, enables a proper functioning of the nervous system, which was proved that it reduces the risk of Parkinson's disease, and demonstrates a positive effect on the behavior of children with autism.
Pantothenic acid (Vitamin B5) – amide of a pantoin acid and beta-alanine; after absorption it undergoes different metabolism changes. As fosfopantotein, it participates in the reaction leading to the formation of coenzyme A – a biologically active form of a pantothenic acid – and ACP – a protein carrier of acyl groups.
Coenzyme A (CoA) acts as a carrier of acyl groups (mostly as acetyl coenzyme A – acetyl –CoA) in many important metabolic processes, including Krebs cycle. Acetyl-CoA is involved in acetylcholine synthesis, and the excretion of sulfonamides. Furthermore, it is a cholesterol precursor, and therefore, steroid hormones as well.
A pantothenic acid determines the correct metabolism of proteins, sugars and fats, accelerates wound healing, prevents fatigue, and improves the cardiovascular system, is involved in tissue regeneration, improves pigmentation and hair condition. Its deficiency contributes to nervous system disorders, learning difficulties and excessive irritability.
Vitamin B1 (Thiamine) – is a water soluble vitamin which, after entering the body, is converted into a biologically active form by the action transferase involving ATP – thiamine pyrophosphate acting as a coenzyme of several enzymes (including the pyruvate carboxylase), related to carbohydrate metabolism in the process of cellular respiration.
So, as you can see above, vitamin B1 determines the correct process of obtaining energy from carbohydrates (glucose). In addition, it is responsible for the proper synthesis of acetylcholine – an important neurotransmitter responsible, among others, for skeletal muscle contraction and for cognitive and memory functions.
Thiamine deficiency leads to the dysfunction of the central nervous system, thereby causing weakness, fatigue, disorders of memory and concentration, and depression.
Vitamin B2 (Riboflavin) – is essential for the proper functioning of the nervous system and mucous membranes. It plays an important role in the process of cellular respiration leading to the production of energy, where it is a precursor of two major nucleotide-coenzymes: FNN and FAD, which are also its active form.
Riboflavin cooperates with vitamin A for the proper functioning of the eye, mucous membranes in the respiratory tract, the epithelium of the blood vessels, as well as the mucosa of the gastrointestinal tract. Its deficiency may cause blurred vision, corneal damage and eyeballs, inflammations of mucous membranes, muscular dystrophy, and functional disorders of the nervous system.
Vitamin B3 (Niacin) – is also known as vitamin PP – it occurs in two forms: a nicotinic and nicotinamide acid. Its deficiency leads to pellagra – a disease manifested by inflammation of the skin, dementia (dementia), depreciation, aggression, insomnia, and impaired coordination of body movements. It can be produced from tryptophan in the body, but the process is not sufficient to ensure the proper amount of it.
It plays an important role in regulating a blood cholesterol level. By blocking the breakdown of fats in fat tissue, it leads to a reduction in LDL (called bad cholesterol), reduces the amount of a free fatty acid (FFA) level, and total cholesterol. Meta-analysis of clinical trials have shown, that vitamin B3 significantly reduced the incidence of atherosclerosis and coronary artery diseases.
Biotin (vitamin B7, vitamin H) – it is produced by intestinal bacteria, as a coenzyme of the enzyme carboxylase, which means that it participates in the transmission of the carboxyl group to various organic compounds – including in the process of gluconeogenesis, Krebs cycle (citric acid cycle), and the synthesis of a number of fatty acids. It supports thyroid functioning, and influences the properties of the skin and hair.
Choline (choline bitartrate) – is a combination of a tartaric acid and choline in the form of an ester, which in this form is a precursor of acetylcholine – a neurotransmitter responsible for memory functions, logical reasoning and ability to concentrate. Choline is a water soluble substance, which is believed to be a vitamin due to its biological importance.
It is a substrate in the synthesis of phosphatidylcholine and sphingomyelin, which are the building blocks of phospholipids of all cell membranes of cells. This is particularly important for glial cells forming myelin sheath around axons, responsible for the isolation and improvement of the transmission of nerve impulses.
Inositol (or vitamin B8) – is called the fertility vitamin or happiness vitamin; It can be synthesized by the body, but the process does not cover the full demand. It builds phosphatidylinositol, which is being phospholipid component of cell membranes, and a precursor of important secondary transmitters (intracellular mediators), being intermediary in the exchange of chemical information: triphosphate (IP3) and diacylglycerol (DAG).
Inositol is also a very important component of sperm, it regulates menstrual cycles in women, and prevents hyperinsulinemia. In addition, it has an impact on the nutrition of central nervous system cells, including the brain, and reduces the level of "bad" cholesterol.
In summary, Jarrow Formulas B-Right is a dietary supplement designed for each person to make up for deficiencies of B vitamins. It is especially recommended for athletes who are under the influence of a large amount of training they torment the neuromuscular system, and those unusually mentally active people (as a nootropic preparation). The product can also be recommend for people living in the rush and constant stress, as well as for therapeutic purposes in various disease states after consultation with a specialist.
This product contains niacin (vitamin B3). This compound, when used on an empty stomach can cause discomfort, so-called "niacin flush." It is manifested in the form of burning, tingling and redness of the skin. These symptoms may last for about half an hour. For some people, this feeling can be quite pleasant, but if you want to avoid it, use the product with a meal.
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|per 1 capsule||amount||%DV|
|Thiamin (as thiamin mononitrate)||25 mg||2080%|
|Niacin (as nicotinic acid)||25 mg||160%|
|Vitamin B6 (as pyridoxine HCl)||25 mg||1470%|
|Vitamin B6 (as pyridoxal 5-phosphate)||10 mg||590%|
|Folate (as QUATREFOLIC (6S)-5-methyl-tetrahydrofolic acid glucosamine salt)||400 mcg||100%|
|Vitamin B12 (as methylcobalamin)||100 mcg||4170%|
|Vitamin B5 (as calcium D-pantothenate)||100 mg||2000%|
|Choline (as choline bitartrate)||50 mg||10%|
|Pantethine (Vitamin B5 derivative)||25 mg||-|
Silicon Dioxide, Calcium Phosphate, Magnesium Stearate (Vegetable Source), Cellulose And Stearic Acid (Vegetable Source), Hydroxypropylmethylcellulose (Capsule)
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