Blog us   | en | EUR
0 0.00 €
 sales@mz-store.com  +1 844-530-3647
Since 2005
Add to Cart
Methyl Folate Methyl Folate 400mcg 60 caps.
Jarrow Formulas
6.68 €

Methyl Folate

All variants:

Min. expiration date: 2024-03

From 3 units only: 6.55 € / Units. -2%

Shipping weight: 80g
No gluten
6.68 € With VAT
0.11 € / serving
Add to Cart
The seller, importer and entity responsible for the description is:
Description
  • Bioactive (methylated) form of folate
  • Recommended for pregnant women
  • Affects amino acid metabolism
  • Participates in erythropoiesis
  • Regulates the level of homocysteine
  • Maintains normal psychological functions
  • Supports the functioning of the immune system
  • Reduces the feeling of fatigue and tiredness
  • Participates in cell division

Jarrow Formulas Methyl Folate is a dietary supplement with a biologically active type of the fourth generation folate (Quatrefolic®) in a methylated form, i.e., 5-MTHF, also called vitamin B9 or B11.

Folic acid regulates cell growth and functioning, has a beneficial effect on the nervous system and the brain, prevents neural tube damage in foetuses, is beneficial for the development of new-born babies, regulates cell division and participates in blood production.

Participation in erythropoiesis
A relationship has been observed between consuming folic acid and the normal process of red blood cell production (erythropoiesis). The acid’s deficiencies lead to errors in DNA synthesis, and the incorrect fragments are cut out of the chain. When the process occurs several times, it leads to DNA fragmentation and cell cycle disorders that cause megaloblastosis, which is a morphological representation of biochemical disorders leading to the inhibition of DNA synthesis.

The main clinical effect of folic acid deficiency is megaloblastic anaemia, characterised by large, abnormally nucleated red blood cells that cumulate in bone marrow. As a result of general decrease of cell division, a reduction in the number of white blood cells and thrombocytes is also observed.

Participation in homocysteine metabolism
Methyl folate (5-MTHF) is an important regulating element during the production of methionine from homocysteine. Obstacles in homocysteine metabolism result in the accumulation of the substance in intracellular space and its subsequent export to the blood. Depending on the extent of disorders, its level in blood plasma can increase to a different extent. Hyperhomocysteinaemia in people is thought to be a risk factor of developing cardiovascular and neurodegenerative diseases, congenital malformations and cancer.

Participation in cell division
During the S-phase of the cell division cycle, the cell's DNA is replicated. The process depends on the presence of folate's active forms, and their deficiencies make the right synthesis of deoxyribonucleic acid impossible. Folic acid's additional function in nucleotide production consists in de novo synthesis of adenine and guanine, two out of four nitric bases that constitute the DNA chain.

Support for the immune system
Folic acid plays a key role in nucleotide synthesis, so it can affect cell proliferation in the immune system and its reactions. Folate deficiencies have been observed to reduce the proliferation of many cell types.

Cells deprived of folates are accumulated in the S-phase as a result of the distortion of nucleotide balance and slower DNA synthesis. When cells are provided with folic acid they were lacking, the accumulation in the S-phase is reversed and the division restored. Folic acid deficiency has also been proven to reduce the amount of circulating T lymphocytes and their proliferation.

Participation in amino acid synthesis
Folic acid coenzymes are active in amino acid metabolism, including histidine catabolism into glutamic acid, serine transformation into glycine and homocysteine remethylation into methionine. Folic acid mediates in transporting single carbon atoms from serine. The conversion of homocysteine into methionine serves mainly as a source of methionine for S-adenosyl methionine, which is a methyl group donor in many reactions of protein, nucleoprotein, histone, neurotransmitter and phospholipid methylation.

Maternal tissue growth during pregnancy
Folic acid is needed during pregnancy in order to increase the mother's erythrocyte mass. That causes the formation of a placenta and the development of the foetus, the womb, breasts and other maternal tissue, which is caused by the acid's role in cell division.

Psychological functions
A serious folic acid deficiency in people is characterised by the occurrence of macrocytic anaemia, which causes such symptoms as weakness, fatigue, concentration problems, irritability, headaches, palpitations and dyspnoea. Therefore, a cause and effect relationship has been noted between the consumption of folic acid and its contribution into maintaining normal psychological functions.

Recommended supplementation - for whom?
Folic acid supplementation is particularly recommended for all people vulnerable to its deficiencies, that is: pregnant women, adolescent girls, infants, elderly people, excessive alcohol drinkers, and those who follow a starvation diet or one based on a single product.

Moreover, deficiencies may occur in people susceptible to absorption and folate transformation disorders, during chronic diseases of the gastrointestinal tract and those who are on various drug treatments.

Directions for use
Manufacturer, Wholesaler, Seller
Reviews (0)
Nutrition facts
Similar products
Best to combine with

Latest on blog

MIND diet – will improve memory and reduce the risk of Alzheimer’s disease

MIND diet – will improve memory and reduce the risk of Alzheimer’s disease

Alzheimer’s disease is nowadays one of the most common neurodegenerative diseases. It results in loss of nerve cells in the brain, leading to memory...

Read more

Paleo diet – what does it consist of? What should we not eat on this diet?

Paleo diet – what does it consist of? What should we not eat on this diet?

The Paleo diet aims to imitate as closely as possible the diet of the Paleolithic man. Paleo diet – we eat lean meat and fishPaleo diet – eggs, seeds...

Read more

Psyllium – for digestive problems, coughs, and wounds

Psyllium – for digestive problems, coughs, and wounds

As a medicinal plant, Psyllium has been known since ancient times (both in Europe and China). For years they have also been used in natural medicine. Due to their...

Read more

Donuts – how many calories do they have? How to get rid of donut calories?

Donuts – how many calories do they have? How to get rid of donut calories?

Donuts are known almost all over the world and depending on the region they may differ in filling (or lack thereof) and how they are called. Although they were...

Read more

Vitamin E – more than the vitamin

Vitamin E – more than the vitamin

Vitamin E is actually not a single, specific substance, but rather a group of chemical compounds. The demand for it depends on age and gender. Young children need...

Read more

3 dietary changes your body will thank you for

3 dietary changes your body will thank you for

Replace white bread with whole-grain breadChoose brown rice, pasta, and groatsReplace sweets with nutsSummary Replace white bread with whole-grain bread Whole...

Read more
Sign up for our newsletter
And receive coupons, news, special offers and much more!

Customer service

MZCatalog - recommended dietitians
MZCatalog - recommended trainers
MZCatalog - recommended clubs