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NOW FOODS & D-3 K-2 Liposomal Spray is a dietary supplement with a combination of 1000 IU Vitamin D3 and 100 mcg of vitamin K2 per serving. A liposomal formulation provides better absorption compared to traditional supplements in capsules and tablets. Its absorption exceeds 90%.
Vitamin D3 (cholecalciferol) is a steroid belonging to D vitamins. The synthesis of cholecalciferol occurs in the skin under the action of UV-B rays on a derivative of cholesterol – 7-dehydrocholesterol. Inactive cholesterol is converted in the kindeys and the liver into the active form – calcitriol. Vitamin D shows a hormonal action, has its own nuclear receptors (VDR – vitamin D receptor) in cells. This vitamin is soluble in fats.
Vitamin K2 (menaquinone)– a compound belonging to K vitamins. It affects mainly calcium balance and the maintenance of a healthy skeleton. Its action differs greatly from the one of vitamin K1 (phylloquinone) and these vitamins should not be confused. Vitamin K, as well as vitamin D, is fat-soluble.
What are liposomes?
Liposomes are vesicles surrounded by a lipid bilayer, filled with water or a water solution. Their structure resembles biological membranes enclosing cells and intracellular organelles. They are effectively used as carriers of drugs and nutrients. Their high bioavailability is achieved by providing vitamins through the digestive system directly into the bloodstream. Liposomal supplements are also gentler to the digestive tract.
The causes of deficiency
The main source of vitamin D is the synthesis of cholesterol taking place in the skin. The reaction is promoted by the exposure to UVB rays which reach our skin in the afternoon. Unfortunately, during this time we are mostly in work or school, indoors, where we do not have any direct contact with sunlight. Frequently, even when we can enjoy the sun in the appropriate hours, most of the surface of our skin is covered with clothes.
These factors definitely do not help us maintain adequate levels of vitamin d. The situation is even more problematic in the autumn-winter period, when the exposure of our skin to the sun is not possible due to a low temperature.
Vitamin K2 is synthesised in the intestines by microbiota. In today's era of ubiquitous antibiotics and heavily processed food, microbiome disorders are common which also reduces the level of available vitamin K2.
The effect on the skeletal system
Vitamin D supplementation improves the absorption and use of calcium and phosphorus. It also stabilises calcium blood levels. This results from the effect of this vitamin on parathormone secretion by parathyroid glands. Parathormone is responsible for increased release of calcium from its reserves, mainly from bones. Vitamin D significantly reduces levels of this hormone in the blood.
Studies show that vitamin D and K2 levels are associated with the incidence of bone fractures. It can therefore be concluded that supplementation with a combination of these vitamins can potentially increase the strength of our bones.
The function of vitamin K2 in regulating calcium balance involves activating the next hormone –osteocalcin. Osteocalcin, to put is simply, causes that calcium is transported where it should be, namely to bone tissue and teeth. It has been observed that increased osteocalcin levels are correlated with higher bone mineral density.
The effect on the cardiovascular system
People with vitamin D deficiency are more prone to cardiovascular diseases than people with normal levels of this vitamin.
Vitamin D may reduce blood pressure in people with hypertension. The activation of VDR receptors by this vitamin consequently reduces the expression of gene responsible for the production of renin which raises our blood pressure. It is also worth noting that pressure is not reduced in persons with normal laboratory results.
By increasing osteocalcin levels and activating MGP protein, not only does vitamin K2 improve the transport of calcium to bones, but also reduces its accumulation in other tissues in which excess calcium is unwanted. The correct levels of this vitamin prevents the hardening and calcification of blood vessels and the accumulation of atherosclerotic plaques.
The effect on the nervous system
Vitamin D deficiency can cause symptoms of depression. It is worth including vitamin D supplement in our diet when we observe a lower mood or have little energy and motivation. Low vitamin D levels are correlated with a higher incidence of serious neurological diseases such as Alzheimer's, Parkinson's disease or multiple sclerosis.
The impact on testosterone levels
It has been shown that raising vitamin D levels results in increased total testosterone and decreased SHBG levels in men. This action has been confirmed despite of adverse factors like smoking, drinking alcohol or excessive body weight. The supplementation can also reduce the decline in androgen resulting from the ageing of the body. Vitamin D supplementation should be considered in people with low total or free testosterone levels or high sex hormone binding globulin levels.
The addition of vitamin K may maximise the effect on testosterone. It happens so thanks to osteocalcin which stimulates Leydig cells to produce testosterone.
The impact on insulin sensitivity
It has been shown that blood vitamin D levels are inversely correlated with the level of insulin sensitivity. High levels of this vitamin can also lower insulin levels on an empty stomach. It has also been confirmed that it reduces the likelihood of type 2 diabetes in people affected by the disease.
The part here is also played by vitamin K2 which, thanks to the mentioned osteocalcin, induces the release of adiponectin by fat cells. Adiponectin shows the action improving tissue sensitivity to insulin. An additional advantage of adiponectin are its anti-inflammatory properties.
The effect on body fat reduction
It is believed that low vitamin D levels are associated with obesity. What's more, the lower levels of the vitamin, the higher obese class is reached.
Vitamin K2 also reduces the amount of body fat owing to the action of adiponectin, which is released from fat cells due to the activity of vitamin K-dependent osteocalcin.
The action on physical capacity
It has been proven that vitamin D can affect both muscle regeneration after physical damage as well as resistance training.
Vitamin K2 affects the function of mitochondria It appears that the presence of menaquinone helps retain the ability of mitochondria to form ATP molecules in response to stimuli that could impair this process. It can be concluded that vitamin K2 supports energy balance.
The effect on the immune system
Vitamin D supplementation has a proven effect on reducing the duration of colds or flu. Therefore it is worth to try it, especially when we get the disease.
Low vitamin D levels are linked with higher incidence of various autoimmune diseases, such as multiple sclerosis or Crohn's disease. There is also a higher risk of developing some type of cancer, e.g. breast, colon, prostate or ovarian cancer.
Lower vitamin D levels are also associated with atopic dermatitis. The supplementation with this vitamin is likely to relieve symptoms of the disease. In case of asthma, the administration helps reduce the number of attacks in children.
The effects of shortages
Vitamin D deficiency may result in an increased probability of many diseases. These include cancers, autoimmune, neurological, cardiovascular diseases, depression and atopic dermatitis. Also reduced testosterone levels and lower insulin sensitivity are observed.
Who will benefit?
Taking the combination of vitamin D3 and K2 should bring benefits basically to everybody. However, they should particularly interest people experiencing a lower mood, cardiovascular and skeletal problems, dealing frequently with diseases and certainly those with deficiencies confirmed with blood tests. This supplement is especially recommended in the autumn-winter period because vitamin D reaches then lower levels.
It is estimated that vitamin D deficiency affects over 50% of the world population. Factors that increase the demand for this vitamin are: age, overweight or obesity, insufficient supply of vitamin D, along with diet, as well as kidney and liver diseases.
Now Foods is a company with years of experience in the industry that offers a wide range of nutrients and dietary supplements. Brand is known for its high-quality products designed for hair and nails and supplements supporting the immune system. The offer includes the antioxidant supplements, antibacterial supplements, reducing appetite supplements, products supporting the reduction of body fat and improving digestion. All products are made from natural ingredients.
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De-ionized Water, Vegetable Glycerin, Xylitol, MCT Oil (medium chain triglycerides) (from coconut/palm kernel oil), Natural Fruit Flavors, Phospholipids (soy), Rosemary Extract (Rosmarinus officinalis) (Leaf), Potassium Sorbate (as preservative) and Citric Acid.
Vitamin D belongs to fat soluble vitamins, occurs in three forms: calciferol (vitamin D1) ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), it is formed under the action of sunlight for at least 15 minutes per day. In the absence of sunlight it should be administered in the diet in the form of fish oil (Vitamin A + D3) and fish oils. It is responsible for the absorption of calcium and phosphorus. It is the building substance of bone tissue particularly necessary during pregnancy, childhood, and for athletes. It is a component of dietary supplements and nutrients among competetive athletes. Deficiency of vitamin D causes children growth inhibition, and rickets.
For adults - deficiency causes osteomalacia.
Excess of vitamin D causes headaches, alopecia, nausea, drowsiness, blurred vision, pain in the long bones, the deposition of calcium deposits.
Dosage: 400 IU units during the day.
Cholecalciferol, or vitamin D3, is an organic chemical that belongs to the family of D vitamins. It is naturally found in fatty fish, fish oil, egg yolks, milk and dairy products. It is also synthesized in the human body. It is formed from 7-dehydrocholesterol present in the keratinocytes of the spinous and the basal layers of the epidermis, and a pre-requisite for initiating this process is the action of 290-315 nm wavelength UVB radiation on the skin.
Cholecalciferol is a biologically inactive compound. In the body, it undergoes enzymatic hydroxylation – first in the liver, with the participation of 25-hydroxylase, when calcidiol is formed and secondly in the kidneys, where under the influence of 1-α-hydroxylase, calcidiol is converted into the final active form – calcitriol.
The most important role of vitamin D3 in the body is the regulation of calcium-phosphate metabolism, which directly affects normal skeletal mineralization. In addition, it is involved in cell proliferation and differentiation, insulin secretion, as well as in some functions of the nervous, endocrine and immune systems.
Cholecalciferol is the most popular form of vitamin D used in dietary supplements. Studies show that supplementation with vitamin D in this form most effectively and rapidly raises the level of 25 (OH) D3 – a metabolite that is a marker of the level of vitamin D in the body.
Dosage: according to RDI standards for individual age groups.
Lanolin is obtained in the process of cleaning of raw sheep wool from the so-called wool fat, protecting it from getting wet and unbeneficial weather conditions.
Lanolin is commonly used for the production of ointments and creams with lubricating and softening effect, however, it also found application in the production of dietary supplements and more precisely vitamin D3.
In order to obtain vitamin D3 from lanolin, it undergoes cleaning and crystallization and then proper chemical processes, as a result of which 7-dehydrocholesterol is produced - a precursor of vitamin D3, the same which is produced in skin under the influence of UV radiation. 7-dehydrorocholesterol obtained from lanolin is then subjected to the above mentioned radiation, being transformed to vitamin D3.
Vitamin K exists in the triad of vitamins: menaquinone (vitamin. K1), menadione (vitamin. K2) and menadione (vitamin. K3), soluble in fat. It is produced by bacteria in the human colon. Natural sources of vitamin. K are: eggs, kale, cauliflower, cabbage, meat, milk, lettuce, spinach, fish oil and liver. The synthetic form is administered to newborns, to reduce the sterility of the gastrointestinal tract. Used as a antihaemorrhagic, due to its participation in the process of prothrombin. Increases antibacterial and antifungal immunity. Prevents abundant bleeding during menstruation of women.
Vitamin K deficiency causes external bleeding and ecchymosis on skin, decreased prothrombin synthesis in the liver (especially while taking antibiotics and sulfanilamide).
What is menaquinone?
Menaquinone is the term used for vitamin K2. It appears in short- and long-chain forms, the most popular of which are MK-4 and MK-7, containing respectively 4 and 7 isoprene residues in the side chains.
Vitamin K2 exhibits the widest spectrum of its activity by means of osteocalcin, which it has the ability to activate. By means of this hormone produced by bone cells, it may support the state of mineral density of bones and the condition of blood vessels and lower the risk of circulatory diseases. An interesting property of this vitamin is stimulation of Leydig cells to synthesize testosterone, which will be of interest especially to men. K2 also has neuroprotective properties, protecting from excitotoxicity caused by glutamate and oxidative stress from glutathione deficiency. Osteocalcin may also increase adiponectin release from fatty cells, thanks to which it is possible to achieve better insulin sensitivity and decrease inflammations.
Menaquinone is contained in dietary supplements available in the offer of muscle-zone.pl.
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