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SAMe SAMe 400mg 30 tab.
Now Foods
40.20 $


Servings: 400mg 30 tab.

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For free shipping is missing: 81.00 $
40.20 $With VAT
1.34 $ / serving

From 3 units only 39.40 $ /Units. -2%

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  • Natural support for brain health
  • Supports good mood
  • Helps in depression treatment
  • Improvement of cognitive skills
  • Supports the proper brain functions
  • Strengthens liver cells
  • Protection against free radicals
  • Helps to protect your joints

Now Foods SAMe is a dietary supplement which contains 400 mg of S-Adenosyl methionine – a natural substance contained in each cell of the human body system. Its particularly high activity is observed in the cells of brain, liver, adrenal glands or pineal gland. Scientific research proved that it has a great impact on the improvement and stabilisation of our well-being as well as supports the functions of brain and liver.

S-Adenosyl methionine (SAM-e) is naturally synthesized in the human body system from ATP and methionine amino acid. It is called a universal donor of methyl groups, involved in biochemical transformations in all the cells of the body system. The scientists are investigating its influence on the stabilisation of neurons cell membranes, its participation in the synthesis of neurotransmitters and hormones as well as its protective influence on the hepatocytes (cells that form the liver). All this aspects are believed to contribute to the particular importance of SAM-e.

Methylation is a process which continually occurs in our body system. It concerns both enzymatic and structural proteins, phospholipids, glutathione (an antioxidant), DNA, RNA and many other active substances. It can be said that the aim of this process is to regulate biochemical processes which occur in each cell, by activating or deactivating various compounds. It is essential to maintain the health and homeostasis of all tissues and internal organs.

Proper brain functions
There are numerous scientific reports describing the role of SAM-e in the proper functioning of the human brain. As a universal donor of methyl groups, it is involved in the synthesis of phosphatidylcholine – a compound which is responsible for an appropriate structure and functions of cell membranes, including neurons.

S-adenosylmethionine is also necessary for the synthesis of the neurotransmitters which are essential for the functioning of the brain, such as serotonin, noradrenaline or dopamine. It is also involved in the production of melatonin – a hormone that regulates the healthy sleep Many researchers suggested that SAM-e may have neuroprotective properties as well as it can support thinking processes and prevent nervous system diseases.

Good mood
There are numerous aspects of the proper functioning of the brain and one of them is the proper functioning of such neurotransmitters as serotonin, dopamine or noradrenaline. Their disturbed synthesis may lead to a decrease in well-being and mood or even to serious diseases, such as depression. The researchers suggest that the use of the SAM-e may positively influence the regulation of the synthesis of these substances and thereby protect the body system from this type of disorders.

Since in people suffering from depression a decrease in the level of numerous neurotransmitters, particularly serotonin, can be observed, the scientists conclude that the supplementation with SAM-e can result in the improvement of their synthesis and thus it can support the treatment of this disease.

Previous studies seem to confirm this hypothesis, since in many cases an improvement in the patient health has been reported. It is also worth noting that S-adenosylmethionine does not cause any side effects, contrary to the widely used antidepressant drugs.

Improvement of cognitive skills
Our brain requires the proper functioning of both neurons and all neurotransmitters to be able to properly receive and process the information. Because SAM-e affects these both levels, it seems that its supplementation should stimulate the cognitive functions of our brain and prevent them from declining with age or in various neurodegenerative diseases.

Influence on the liver cells
The liver is one of the most important organs in our body system. Thousands of biochemical reactions which occur constantly in the body system determine our health, i.a. due to the synthesis of numerous proteins, detoxification of the body system or storage of vitamins.

It has been demonstrated that the decrease in the concentration of S-adenosylmethionine in liver cells (hepatocytes) can lead to serious disturbances in their functions. Most probably, it is caused by the fact that SAM-e plays an important role in the synthesis of glutathione – a compound which naturally occurs in the body system and shows great antioxidant potential. The undisturbed action of this compound allows for the effective protection of hepatocytes from damage caused by oxygen free radicals.

Since glutathione is synthesized not only in the liver, a positive influence of SAM-e in this area may also be important for other tissues of the body system. It is suggested that supplementation may enhance systemic fight against oxidative stress.

Fight with joint pain
Arthritis, especially arthritis of the lower limbs, is a serious problem of many older people. It significantly reduces the ability to move and, consequently, it negatively affects many everyday activities. There are studies which indicate the positive effect of SAMe in this type of disease, by improving the functioning of joints and reducing pain and inflammation. One of the mechanisms which explain this activity is the participation of SAM-e in the synthesis of proteoglycan and its anti-inflammatory and analgesic properties.

To sum it all up, Now Foods SAMe is a natural dietary supplement with a very wide spectrum of health promoting properties. It is especially recommended for the elderly people who want to take care of their health and the proper functioning of brain for many years. It can be also applied in people with low mood and well-being, who are overtired and want to support their mind. There are also extensive reports that supplementation with SAM-e may support the treatment of depression.

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Container size: 30 tabletsServing size: 1 tabletServings per container: 30
per 1 tabletamount%DV
SAMe (S-Adenosyl-L-Methionine)400 mg-

Other ingrednients

Cellulose, Croscarmellose Sodium, Magnesium Stearate (vegetable source), Silica, Stearic Acid (vegetable source), Ascorbic Acid, Citric Acid and Enteric Coating (water, methacrylic acid, methyl methacrylate, glycerin).

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Exogenous methionine is an amino acid containing sulphur in its composition. It provides multi metabolism, with the indispensable help of vitamin B6. Participates in the synthesis of phospholipids (e.g. Lecithin), carnitine responsible for transport in the body of long-chain fatty acids, burned in the mitochondria cells (organelles in cells with a separate kernel), along with cystine forms cysteine. It is in the body antioxidant function. Natural source of acquisition of methionine are high-protein foods of animal origin (eggs, meat, fish), vegetable (sesame seeds, grain products). Available in all protein and carbohydrate protein and amino acid supplements such EAA and contain so-called all-day amino acids, supporting the liver preparations and cosmetics supporting the growth and condition of hair, skin and nails.


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