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Bioactive Complete B-Complex of the Life Extension company is a supplement containing the whole array of B vitamins in large doses. Its supplementation is recommended to physically active people or those with its huge deficiencies and with methylation problems caused by genetic mutations. Vitamins from B group are the compounds soluble in water, essential to maintain health. The ingredients contained in this supplement are in a biologically active form.
Vitamin B1 (as thiamin hydrochloride) – is a vitamin used by all living organisms, but people cannot produce it by themselves, so it has to be delivered in a diet. It is contained in the list of the most important substances necessary to maintain health according to WHO (World Health Organization).
The main function of this vitamin is transforming carbohydrates into energy, but it also lowers cortisol, accelerates wound healing, alleviates pain and regulates carbohydrates metabolism, processing its surplus, which may turn out to be extremely vital to people whose diet contains high amounts of this macronutrient.
Moreover, thiamine is required for the nervous system health and is used among others in the biosynthesis of many cellular components, including neurotransmitters, such as acetylcholine or GABA. It was also proven that it supports growth processes among children and is used in the production of hydrochloric acid in the stomach, which in turn facilitates digestion.
Vitamin B2 (as riboflavin and riboflavin 5'-phosphate) – its main function is also changing carbohydrates into energy and their metabolism by processing its excess. It influences fatty acids synthesis, is responsible for appropriate vision and helps the organism dispose of toxins. It may turn out to be indispensable for people who have a copy of MTHFR 677TT gene, where homocysteine is increased due to the disturbed metabolism of folic acid. Among such people, even low riboflavin doses may diminish homocysteine level and reduce blood pressure. Higher doses of this vitamin, on the other hand, have a proven therapeutic effect in treating migraines and anemias (by increasing iron utilization).
Vitamin B3 (as niacin and nicotinamide) – niacin supplementation is very effective in lipid panel regulation. The increase of HDL-C was observed among people with low levels of this lipoprotein, while among people with high levels of LDL-C, the lipoprotein level decreased. The decrease of triglycerides was also noted.
Vitamin B3 is also a precursor of nicotinamide adenine dinucleotide in the oxidized form (NAD+), which in turn is responsible for the range of metabolic processes, among others, supporting Krebs cycle, indirect sirtuin activation (proteins: SIRT1, SIRT2, SIRT3, SIRT7), increasing mitochondria activity and facilitating the creation of new ones, inhibiting cell apoptosis and many other. Nicotinamide is also used with the aim to maintain healthy skin and hair.
Vitamin B6 (as pyridoxine hydrochloride and pyridoxal 5-phosphate [P-5-P]) – P-5-P is an active vitamin B6 form that influences protein metabolism – participates in the process of protein transformation, intensifies its synthesis, lowers prolactin secretion, influences glycogenesis and strengthens the immune system. It is also responsible for the synthesis of many other neurotransmitters, such as serotonin, dopamine and GABA. Decreased number of inflammation states in the organism - lower markers, such as OB and CRP, thanks to which it also regulates the work of the bowels – decreased inflammations IL6, TNF-α and NF-KB.
Vitamin B6 also influences histamine metabolism by affecting the proper functioning of DAO (diamine oxidase), i.e. the enzyme decomposing histamine. It improves the functioning of morning cortisol and stimulates the part of the brain during REM phase, which influences more pronounced dreams. Both these functions considerably increase the comfort and recovery properties of sleep.
Methylfolate (as 5-MTHF – calcium salt of levomefolic acid) – sometimes called vitamin B9. It is an organic compound, an active form of folic acid, which does not have to go through enzymatic reductase by MTHFR in order to become biologically active. It plays an important function in DNA synthesis, the conversion of homocysteine to methionine and tetrahydrofolian, cysteine metabolism and the synthesis of neurotransmitters, such as: serotonin, dopamine, norepinephrine. It is necessary to the creation and proper functioning of erythrocytes (along with vitamin B12 and iron). It also supports the functioning of the central nervous system.
Vitamin B12 (as methylcobalamin) – participates in the process of red cells creation, helps to protect liver, takes part in the synthesis of certain amino acids and nucleic acids, stimulates appetite. Methylcobalamin is the most bioavailable form of vitamin B12, which crosses the blood-brain barrier, thanks to which it also influences the functioning of the central nervous system and neurotransmitters. Most importantly, however, it supports methylation processes and histamine metabolism (similarly to vitamin B6). This vitamin is a cofactor of methionine synthase, which catalyzes homocysteine to methionine conversion, which takes place in the reaction with 5-MTHF.
Biotin (called vitamin B7) – fulfills the function of a coenzyme for the enzymes called carboxylases, which participate in the synthesis of fatty acids, isoleucine, valine and in gluconeogenesis (generating glucose from non-carbohydrate substrates). Biotin is essential for cell growth, fatty acids production, fat and amino acids metabolism. It helps in maintaining a constant glucose level in blood. It positively influences skin and hair properties.
Pantothenic acid (as calcium pantothenate) – also called vitamin B5; its main role in a human body is ensuring a substrate, which is required to create coenzyme A, an essential cofactor for many enzymes in a human body.
Inositol – restricted chemical compound from glycitols group. It is sometimes defined as vitamin B8, however, it is not a vitamin, as it may be synthesized by the organism. It helps in the treatment of the polycystic ovary syndrome (PCOS). Among women with this syndrome, inositol may effectively restore ovulation and fertility, as well as decrease resting glucose level in blood. Higher doses of inositol act anti-anxiety, anti-depression and significantly reduce the number of panic attacks.
PABA (4-Aminobenzoic acid) – a restricted chemical compound belonging to the group of non-protein amino acids. It is sometimes called vitamin B10, but in reality it is classified as “vitagen”, i.e. a substance similar to vitamins. PABA influences the processes connected to protein metabolism, but most importantly, it is in the composition of tetrahydrofolic acid (THF), which is a folic acid metabolite. It is essential to homocysteine methylation to methionine and improves pantothenic acid assimilability.
What is it about this methylation?
Methylation is the process taking place relentlessly in all cells. During its transmission, there is a methyl group (a carbon atom plus 3 hydrogen atoms) between molecules. Methyl group is connected to the enzyme, which fulfills the appropriate function.
When everything works as it should, MTHFR gene starts a multistage metabolic process – methylation. It looks more less like this:
MTHFR gene codes MTHFR enzyme, which cooperating with folic acid, metabolizes it from the form of – 5,10- methylene tetrahydrofolate to 5- methyltetrahydrofolate;
5- methyltetrahydrofolate helps to transform the amino acid homocysteine into another amino acid – methionine, which is used in many metabolic processes;
In the liver, methionine gets converted to SAM-e (S-Adenosyl methionine), which is the source of methyl groups in the cell metabolism;
Methylation is crucial for many processes, such as detox, growth, regeneration, neurotransmitters and immune cells creation, nervous system, DNA and RNA synthesis, energy production (ARP), building cell walls and histamine elimination.
Defective MTHFR gene
When a person has a defective MTHFR gene, we deal with polymorphism, i.e. an enzyme produced by MTHFR has a changed shape, by which its effectiveness is decreased. A defective enzyme cannot deal with folic acid conversion in the form that is useful for the organism, which increases homocysteine level.
Homocysteine undergoes weak conversion to methionine, which decreases the amount of glutathione in the organism (the strongest antioxidant), which causes the liver to be more burdened. Also by the lower quantity of methionine, the organism produces less SAM-e, which is a provider of methyl groups and is necessary to neurotransmitters production.
Homocysteine comes into being as a result of disconnecting methyl group from methionine. A by-product of this is SAM, which is the main donor of methyl groups. Next, homocysteine may convert back into methionine or undergo a reaction leading to the creation of cysteine.
The first option takes place on the remethylation pathway, where methionine synthase is needed – an enzyme, whose cofactors are vitamin B12 and folic acid. This enzyme transfers the methyl group from N-5- methyltetrahydrofolate – a folic acid derivative, which is produced under the influence of reductase enzyme MTHFR.
The second option takes place on the transsulfuration pathway, where cystathionine β-synthase is needed (CBS), which takes place with the participation of vitamin B6, thanks to which cystathionine is produced and next – under the influence of γ-cystathionase (also dependent on vitamin B6) – cysteine is produced.
The goal of the above mentioned processes is removing homocysteine from the bloodstream – among healthy people – the processes of homocysteine production and removal are balanced. However, by disturbing the above mentioned gene, the amount of homocysteine is too high, non-physiological, which makes it toxic.
Vitamins from B group/ methylation
Methylation is an incredibly complicated and long process and cannot be presented in a few paragraphs. However, the most important is that in order for the process to be successful its all elements have to be present. The lack of one element means stopping the whole process. Vitamins from B group are such indispensable elements.
Due to genetic mutations a lot of people have problems with the proper methylation process. It is therefore important to supplement already methylated substances (such as are contained in the supplement of Life Extension) in order to enable the organism to use them.
Who may use the supplement?
If you want to reduce the homocysteine level, get rid of energy decreases during the day, protect yourself from the excess of free radicals, make methylation processes easier for the organism, support more than 100 enzymatic reactions taking place in your body and protect yourself from cardiovascular diseases, this supplement is certainly for you.
It is recommended to use the product in case of exposure to stressors. In the scientific studies, it was observed that supplementation with a complex of B vitamins had a positive impact on well-being, reduced fatigue and improved concentration in people who are exposed to chronic stress associated with their work.
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|per 2 capsules||amount||%DV|
|Vitamin B1 (as thiamine HCI)||100 mg||9091%|
|Vitamin B2 (as riboflavin and riboflavin 5'-phosphate, sodium)||75 mg||5357%|
|Vitamin B3 (as niacinamide and nicotinic acid)||100 mg||625%|
|Vitamin B6 (as pyridoxine HCI and pyridoxal 5' phosphate)||20 mg||1429%|
|Folate (vitamin B9) (as calcium-L-methylfoliate)||400 mcg||200%|
|Vitamin B12 (as methylcobalamin)||300 mcg||12000%|
|Biotin (vitamin B8)||1000 mcg||2000%|
|Vitamin B5 (D-pantothenate, calcium)||500 mg||8333%|
|PABA (para-aminobenzoic acid)||50 mg||-|
vegetable cellulose (capsule), rice bran, stearic acid, silica.
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