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Bioactive Complete B-Complex of the Life Extension company is a supplement containing the whole array of B vitamins in large doses. Its supplementation is recommended to physically active people or those with its huge deficiencies and with methylation problems caused by genetic mutations. Vitamins from B group are the compounds soluble in water, essential to maintain health. The ingredients contained in this supplement are in a biologically active form.
Vitamin B1 (as thiamin hydrochloride) – is a vitamin used by all living organisms, but people cannot produce it by themselves, so it has to be delivered in a diet. It is contained in the list of the most important substances necessary to maintain health according to WHO (World Health Organization).
The main function of this vitamin is transforming carbohydrates into energy, but it also lowers cortisol, accelerates wound healing, alleviates pain and regulates carbohydrates metabolism, processing its surplus, which may turn out to be extremely vital to people whose diet contains high amounts of this macronutrient.
Moreover, thiamine is required for the nervous system health and is used among others in the biosynthesis of many cellular components, including neurotransmitters, such as acetylcholine or GABA. It was also proven that it supports growth processes among children and is used in the production of hydrochloric acid in the stomach, which in turn facilitates digestion.
Vitamin B2 (as riboflavin and riboflavin 5'-phosphate) – its main function is also changing carbohydrates into energy and their metabolism by processing its excess. It influences fatty acids synthesis, is responsible for appropriate vision and helps the organism dispose of toxins. It may turn out to be indispensable for people who have a copy of MTHFR 677TT gene, where homocysteine is increased due to the disturbed metabolism of folic acid. Among such people, even low riboflavin doses may diminish homocysteine level and reduce blood pressure. Higher doses of this vitamin, on the other hand, have a proven therapeutic effect in treating migraines and anemias (by increasing iron utilization).
Vitamin B3 (as niacin and nicotinamide) – niacin supplementation is very effective in lipid panel regulation. The increase of HDL-C was observed among people with low levels of this lipoprotein, while among people with high levels of LDL-C, the lipoprotein level decreased. The decrease of triglycerides was also noted.
Vitamin B3 is also a precursor of nicotinamide adenine dinucleotide in the oxidized form (NAD+), which in turn is responsible for the range of metabolic processes, among others, supporting Krebs cycle, indirect sirtuin activation (proteins: SIRT1, SIRT2, SIRT3, SIRT7), increasing mitochondria activity and facilitating the creation of new ones, inhibiting cell apoptosis and many other. Nicotinamide is also used with the aim to maintain healthy skin and hair.
Vitamin B6 (as pyridoxine hydrochloride and pyridoxal 5-phosphate [P-5-P]) – P-5-P is an active vitamin B6 form that influences protein metabolism – participates in the process of protein transformation, intensifies its synthesis, lowers prolactin secretion, influences glycogenesis and strengthens the immune system. It is also responsible for the synthesis of many other neurotransmitters, such as serotonin, dopamine and GABA. Decreased number of inflammation states in the organism - lower markers, such as OB and CRP, thanks to which it also regulates the work of the bowels – decreased inflammations IL6, TNF-α and NF-KB.
Vitamin B6 also influences histamine metabolism by affecting the proper functioning of DAO (diamine oxidase), i.e. the enzyme decomposing histamine. It improves the functioning of morning cortisol and stimulates the part of the brain during REM phase, which influences more pronounced dreams. Both these functions considerably increase the comfort and recovery properties of sleep.
Methylfolate (as 5-MTHF – calcium salt of levomefolic acid) – sometimes called vitamin B9. It is an organic compound, an active form of folic acid, which does not have to go through enzymatic reductase by MTHFR in order to become biologically active. It plays an important function in DNA synthesis, the conversion of homocysteine to methionine and tetrahydrofolian, cysteine metabolism and the synthesis of neurotransmitters, such as: serotonin, dopamine, norepinephrine. It is necessary to the creation and proper functioning of erythrocytes (along with vitamin B12 and iron). It also supports the functioning of the central nervous system.
Vitamin B12 (as methylcobalamin) – participates in the process of red cells creation, helps to protect liver, takes part in the synthesis of certain amino acids and nucleic acids, stimulates appetite. Methylcobalamin is the most bioavailable form of vitamin B12, which crosses the blood-brain barrier, thanks to which it also influences the functioning of the central nervous system and neurotransmitters. Most importantly, however, it supports methylation processes and histamine metabolism (similarly to vitamin B6). This vitamin is a cofactor of methionine synthase, which catalyzes homocysteine to methionine conversion, which takes place in the reaction with 5-MTHF.
Biotin (called vitamin B7) – fulfills the function of a coenzyme for the enzymes called carboxylases, which participate in the synthesis of fatty acids, isoleucine, valine and in gluconeogenesis (generating glucose from non-carbohydrate substrates). Biotin is essential for cell growth, fatty acids production, fat and amino acids metabolism. It helps in maintaining a constant glucose level in blood. It positively influences skin and hair properties.
Pantothenic acid (as calcium pantothenate) – also called vitamin B5; its main role in a human body is ensuring a substrate, which is required to create coenzyme A, an essential cofactor for many enzymes in a human body.
Inositol – restricted chemical compound from glycitols group. It is sometimes defined as vitamin B8, however, it is not a vitamin, as it may be synthesized by the organism. It helps in the treatment of the polycystic ovary syndrome (PCOS). Among women with this syndrome, inositol may effectively restore ovulation and fertility, as well as decrease resting glucose level in blood. Higher doses of inositol act anti-anxiety, anti-depression and significantly reduce the number of panic attacks.
PABA (4-Aminobenzoic acid) – a restricted chemical compound belonging to the group of non-protein amino acids. It is sometimes called vitamin B10, but in reality it is classified as “vitagen”, i.e. a substance similar to vitamins. PABA influences the processes connected to protein metabolism, but most importantly, it is in the composition of tetrahydrofolic acid (THF), which is a folic acid metabolite. It is essential to homocysteine methylation to methionine and improves pantothenic acid assimilability.
What is it about this methylation?
Methylation is the process taking place relentlessly in all cells. During its transmission, there is a methyl group (a carbon atom plus 3 hydrogen atoms) between molecules. Methyl group is connected to the enzyme, which fulfills the appropriate function.
When everything works as it should, MTHFR gene starts a multistage metabolic process – methylation. It looks more less like this:
MTHFR gene codes MTHFR enzyme, which cooperating with folic acid, metabolizes it from the form of – 5,10- methylene tetrahydrofolate to 5- methyltetrahydrofolate;
5- methyltetrahydrofolate helps to transform the amino acid homocysteine into another amino acid – methionine, which is used in many metabolic processes;
In the liver, methionine gets converted to SAM-e (S-Adenosyl methionine), which is the source of methyl groups in the cell metabolism;
Methylation is crucial for many processes, such as detox, growth, regeneration, neurotransmitters and immune cells creation, nervous system, DNA and RNA synthesis, energy production (ARP), building cell walls and histamine elimination.
Defective MTHFR gene
When a person has a defective MTHFR gene, we deal with polymorphism, i.e. an enzyme produced by MTHFR has a changed shape, by which its effectiveness is decreased. A defective enzyme cannot deal with folic acid conversion in the form that is useful for the organism, which increases homocysteine level.
Homocysteine undergoes weak conversion to methionine, which decreases the amount of glutathione in the organism (the strongest antioxidant), which causes the liver to be more burdened. Also by the lower quantity of methionine, the organism produces less SAM-e, which is a provider of methyl groups and is necessary to neurotransmitters production.
Homocysteine comes into being as a result of disconnecting methyl group from methionine. A by-product of this is SAM, which is the main donor of methyl groups. Next, homocysteine may convert back into methionine or undergo a reaction leading to the creation of cysteine.
The first option takes place on the remethylation pathway, where methionine synthase is needed – an enzyme, whose cofactors are vitamin B12 and folic acid. This enzyme transfers the methyl group from N-5- methyltetrahydrofolate – a folic acid derivative, which is produced under the influence of reductase enzyme MTHFR.
The second option takes place on the transsulfuration pathway, where cystathionine β-synthase is needed (CBS), which takes place with the participation of vitamin B6, thanks to which cystathionine is produced and next – under the influence of γ-cystathionase (also dependent on vitamin B6) – cysteine is produced.
The goal of the above mentioned processes is removing homocysteine from the bloodstream – among healthy people – the processes of homocysteine production and removal are balanced. However, by disturbing the above mentioned gene, the amount of homocysteine is too high, non-physiological, which makes it toxic.
Vitamins from B group/ methylation
Methylation is an incredibly complicated and long process and cannot be presented in a few paragraphs. However, the most important is that in order for the process to be successful its all elements have to be present. The lack of one element means stopping the whole process. Vitamins from B group are such indispensable elements.
Due to genetic mutations a lot of people have problems with the proper methylation process. It is therefore important to supplement already methylated substances (such as are contained in the supplement of Life Extension) in order to enable the organism to use them.
Who may use the supplement?
If you want to reduce the homocysteine level, get rid of energy decreases during the day, protect yourself from the excess of free radicals, make methylation processes easier for the organism, support more than 100 enzymatic reactions taking place in your body and protect yourself from cardiovascular diseases, this supplement is certainly for you.
It is recommended to use the product in case of exposure to stressors. In the scientific studies, it was observed that supplementation with a complex of B vitamins had a positive impact on well-being, reduced fatigue and improved concentration in people who are exposed to chronic stress associated with their work.
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|per 2 capsules||amount||%DV|
|Thiamine (vitamin B1) (as thiamine HCI)||100 mg||8333%|
|Riboflavin (vitamin B2) (as riboflavin and riboflavin 5'-phosphate)||75 mg||5769%|
|Niacin (as niacinamide and niacin)||100 mg||625%|
|Vitamin B6 (as pyridoxine HCI and pyridoxal 5' phosphate)||100 mg||5862%|
|Folate (as L-5-methyltetrahydrofate calcium salt)||400 mcg||100%|
|Vitamin B12 (as methylcobalamin)||300 mcg||12500%|
|Pantothenic acid (as D-calcium pantothenate)||500 mg||10000%|
|PABA (para-aminobenzoic acid)||50 mg||-|
vegetable cellulose (capsule), rice bran, stearic acid, silica.
Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) is soluble in the liquid. It participates in the metabolism of proteins, fats and carbohydrates. By reducing the amount of fat in the blood do not enable deposition of the body. It helps the absorption of magnesium and vitamin B12 (cobalamin). It works on the muscle antispasmodic and anti-inflammatory pain in the joints. It acts anti. It provides efficient operation of the brain. It increases energy increasing vigor of a man. The demand for vitamin B6 increases during pregnancy and breast-feeding infants. The natural product is: yeast, eggs, wheat germ, meat (liver), wheat bran, nuts, peanuts peanuts, soybeans. There is a hypothesis that can be synthesized by intestinal bacteria.
Deficiency of vitamin B6 causes abnormal metabolism of proteins, decrease in lymphocytes in the blood, causes a feeling of lethargy and fatigue intensifies.
Dosage: 1.5-2.5 mg daily (increased demand during pregnancy and lactation).
Fat is an essential nutrient plant and animal organisms. Because of the nutritional value and composition of fats are divided into: saturated (mono-saturated and multi-saturated fatty acids) and unsaturated fatty acids (including essential fatty acids - EFA). The group of lipids include lipids (triacylglycerols, waxes), complex fats (glycolipids, phospholipids), sterols and isoprenoids. Saturated fatty acids is a group of fatty acids having different carbon chain lengths, in which except for the carboxyl group, each of the carbon atoms is bound by a single bond. May adversely affect the lipid profile, so they can be used in limited quantities. Fats are a concentrated source of energy, with different flavours, facilitating the consumption and swallowing of food. They have building functions (part of cell membranes and co-create the white matter of the brain). EFAs are precursors of tissue hormones and biologically active compounds. The unsaturated fatty acids include fatty acids from the group Omega-3, Omega-6 and Omega-9 (the last digit indicates, on which, counting of the end of the chain, there is a double bond in the appropriate carbon chain. The essential fatty acids include: acids, medium-Omega-3 [n-3 ] included in EFAs [essential fatty acids], and long chain (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) Omega-6 and Omega-9. the number indicates that the last double bond in the carbon chain is on the third from the end carbon atom. The acids from the omega 3 group are essential components of cell membranes, they are precursors of eicosanoids and biological activators. They must be combined with ingestion in suitable proportions of Omega-6 acids.
Dosage: Depending on demand and applied diet. It is generally accepted that fats should constitute 20-30% of the energy (calorie) of meals daily.
Calcium (element chem. symbol Ca, atomic no. 20, the group of alkaline earth metals) is the basic building substance of bones and teeth, in which stored is 99% of the element, in the form of hydroxylapatite. When building bones and teeth, phosphorus is very important in the right proportion. It is a base-forming element and activator of many enzymes (ATPase) necessary to release the energy of ATP. It has a significant effect on blood clotting and regulates blood pressure and neuromuscular conductivity. Thanks to the reduced permeability of cell membranes, it soothes the symptoms of food allergies. Calcium is actively involved in the metabolism of iron interacts with vitamins A, C and D and phosphorus, magnesium. Natural source of calcium are animal products (dairy products, sardines, salmon, sprats eaten with bones) and plant products (nuts, soybeans, sunflower seeds). Absorption takes place in the small intestine (less in the colon), it has an effect on the level of lactose, insoluble fibre, organic acids, alkalinity (low pH). The best absorption have organic compounds (lactates, amino acid chelates etc.). Obstructing the absorption of calcium is caused by: phytic acid and oxalic acid as well as excess fat. Scientific studies have confirmed that the combination of calcium, magnesium, boron and vitamin D in dose 3 mg / 24h effectively prevent osteoporosis. Supplements on the market are both mono-preparation supplements (enriched with vitamin D3) and multi-component supplements, available at www.muscle-zone.pl.
Calcium deficiency disorders manifested in the construction of the bones (osteoporosis) and iron metabolism. The symptoms are: rickets, cramps and muscle tremor, osteoporosis.
Excess resulting from an overdose of calcium supplements containing vitamin D3 for children and adults overdose of calcium (hypercalcemia). Symptoms of hypercalcemia are: lack of appetite, vomiting and constipation.
The dosage administered in various publications are inconsistent: 800 - 1000 mg / 24 h (100 - 500 mg / 24h)
Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl
Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).
What is methylcobalamin?
Methylcobalamin is a biologically active form of vitamin B12. It is one of the two forms of this vitamin that may be used as cofactors in various reactions. It differs from popular cyanocobalamin in the presence of methyl group instead of cyanide, thanks to which it releases the organism from the need of neutralizing this harmful factor.
The methyl group from methylcobalamin may be transferred to homocysteine, thanks to which it comes back in the form of methionine in order to be further converted to SAMe, which is the main donor of methyl groups in our organism. These methyl groups may be then used in the processes of creatine production, in neurotransmitter metabolism and as DNA methylation, thanks to which we achieve proper energy level, better well-being and generally better condition of the organism. B12 is a coenzyme for three enzymes: isomerase, methyltransferase and dehalogenase.
Apart from the influence on the nervous system, the supply of vitamin B12 is also very important for the proper synthesis of red cells as well as hemoglobin and anemia prevention.
Methylcobalamin in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
Biotin (vitamin H, co-enzyme R) is in a group of B vitamins, due to the presence of sulphur compounds it is involved in the synthesis of ascorbic acid (vitamin C). Also synthesized in the intestines. It enhances the production of hormones and regulates cholesterol levels. It reduces muscle pain. It prevents hair loss and graying of hair. It soothes the skin inflammations. No toxic effects. Often combined with other B group vitamins and vitamin A. The natural sources of biotin are: whole grain bread, yeast, eggs (yolk), milk, brown rice and cheese.
Daily demand: 100-300 mg per day
Inositol is an organic compound from the group of B vitamins soluble in fluids, present in the natural or synthetic form, synthesized in plants, such as brewer's yeast, beans, grapefruit, cabbage, sprout of wheat, melons and animal (liver). Along with choline is included in the lecithin. It affects the cell nutrition of the central nervous system (brain) by reducing the level of LDL (bad cholesterol), this makes it applicable in treatment of Alzheimer's disease and atherosclerosis. It has a calming effect. There has been a beneficial effect of inositol on the skin and hair reported.
Para-aminobenzoic acid (PABA) is soluble in water, part of the vitamin B complex. Synthesized in the body. Participates in energy conversion (metabolism) of proteins. Used in ointments to prevent excessive sun exposure, protecting against ultraviolet radiation. Positive effect on the condition of the skin and hair. According to a recent study, in conjunction with folic acid, allows to restore hair natural colour on gray. Synthesized in the body. Natural source of acquisition are: brewer's yeast, wheat germ, bran, whole grains, and rice and products of animal origin: liver and kidneys.
Dosage - the lack of strict standards daily dose
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