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L-5-MTHF 1000mcg L-5-MTHF 1000mcg 60 caps.
Seeking Health
21.29 $

L-5-MTHF 1000mcg 60 caps.

From 3 units only: 20.86 $ / Units. -2%

Shipping weight: 150g
No gluten
21.29 $With VAT
0.35 $ / serving
We can let you know you when the product will be available again
  • Supports effective methylation processes in body
  • Reduces risk of neural tube defects in foetuses
  • Source of folate in highly assimilable form
  • Reduces damage caused by DNA oxidation
  • Participates in homocysteine metabolism
  • Enhances blood flow
  • Exerts neuroprotective effect
  • Antidepressant properties

Seeking Health L-5-MTHF is a dietary supplement providing the organism with 1000 mcg of pure L-methylfolate – a source of vitamin B9 in the form of an active coenzyme.

The fantastic assimilability of the form stems from the fact that, unlike other forms, it does not require any additional metabolic processes for the organism to utilise it practically entirely. It is particularly important in the case of people with high demand for folates, including pregnant women or people suffering from a mutation of the enzyme MTHFR, which is essential in the reduction of a substrate of folic acid metabolism in the organism (5,10-CH2-THF) to L-methylfolate, whose metabolic activity in that case can drop by even 70%.

The most important role of 5-MTHF in the organism is the participation in methylation processes. It is a methyl group donor in the conversion of homocysteine to methionine (as a by-product, SAMe is created – S-adenosyl methionine, which is the main methyl group donor in systemic processes).

Research has demonstrated versatile positive effects of folates on the nervous system. Their neuroprotective properties have been discovered regarding mainly lead and dexamethasone poisonings as well as high homocysteine levels. However, the most interesting fact is the relationship between those compounds and depressive disorders. Tests clearly show that reduced blood folate levels increase the risk of developing depression. A study managed to foresee a depressive episode directly on the basis of reduced folate levels in the blood serum which occurred before the episode. It was also demonstrated that the time needed for fluoxetine, an antidepressant, to start working is longer in the above-described systemic conditions. Further research on that subject demonstrated a positive synergic effect of folates (in the dosage of 500 mcg) with antidepressant drugs of the groups SSRI and TCA, as well as a reduction of resistance to those drug groups. The effect was much more prominent among groups with naturally low folate levels and even more obvious in the case of women.

Another function of folates is their antioxidant ability regarding the DNA thanks to the fact that it has a 4-hydroxypyrimidine element. Their proper levels in the circulation prevent excessive homocysteine levels, which can damage the DNA by oxidising it. The effect was documented in a test on the basis of the marker 8-OHdG, whose amount decreased in the case of interventional folate supplementation in the doses of 400-800 mcg.

A well-known benefit of folate supplementation is their ability to reduce the risk of neurological complications in pregnancy. The right dosage of folates (according to research, 800 mcg) reduces the risk of neural tube defects to 0.

It is also worth mentioning what effects they have on the circulatory system. Folate supplementation improves the levels of BH4 and nitric oxide while reducing homocysteine levels. All those changes are crucial for improving the permeability of blood vessels.

To sum up, Seeking Health L-5-MTHF is an excellent choice if your goal is interventional or long-lasting folate supplementation. The form of L-methylfolate is the best one available in the case of those compounds because of the lack of the need to metabolise it further in the organism (for comparison, regular folic acid has to undergo four subsequent reactions in order to turn into L-methylfolate, and with each reaction, part of the substance is lost). Folates themselves have a great deal to offer, especially in terms of maintaining the right condition of the nervous system, eliminating free radicals, and the safety for pregnant women.

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Container size: 60 capsulesServing size: 1 capsuleServings per container: 60
per portion (1 capsule)amount%DV
Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt)1000 mcg425%

Other ingrednients

Microcrystalline cellulose, HPMC (capsule), ascorbyl palmitate, L-leucine, and silica.

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Quatrefolic is the glucosamine salt of (6S)-5-methyltetrahydrofolate and also an active form of folic acid. It is an innovative nutrient (fourth generation folate) which is well soluble in water and thus absorbed effectively by the body. As an organic compound ranked among B vitamins, it is necessary for normal functioning at the cellular level.

Adding folates to a diet is recommended especially to pregnant and lactating women. These compounds may contribute to healthy foetal development. According to studies, their intake may reduce the incidence of pregnancy complications.

Some sources report that folate supplementation supports cardiovascular function (blood production) and contribute to healthy immune function.

Quatrefolic may affect the metabolism of homocysteine whose levels increase in the body over time. Adding it to a diet may thus prevent the development of dementia and maintain healthy cognitive functions which is vital to adults, especially the elderly.



Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at

Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).


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