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Doctor's Best Best B Complex is a valued dietary supplement which contains a wide range of B vitamins and vitamin C. In comparison to similar preparations on the market, the product is distinguished by the contents of the biologically active forms of vitamins: B12 in a form of methylcobalamin, folate in a form of 5-methyltetrahydrofolate (5-MTHF) and vitamin B6 as pyridoxal phosphate. To achieve even greater effectiveness of the supplement, riboflavin (B2), niacin (B3) and vitamin B6 were used as a composition of two different forms of these vitamins.
Numerous enzymes and pathways which are involved in the energy metabolism require, for their proper action, the participation of more than one vitamin from the B-group. For instance, two key enzymes of the Krebs cycle (the process of metabolic transformations which leads to the energy production) – pyruvate dehydrogenase and ketoglutarate dehydrogenase – need vitamins B1, B2, B3 and B5 to act properly. Moreover, mitochondria, which produce over 90% of the total energy of the body system, need all the B vitamins for the smooth functioning of most processes.
The transfer of methyl groups
Methionine synthase – an enzyme which transform homocysteine into methionine – requires active forms of vitamin B9 and B12 for the proper functioning. Hyperhomocysteinemia, which can result from the deficiency of both of these vitamins, is considered to be an independent risk factor of cardiovascular diseases, neurodegenerative disorders, fetal malformations and tumours.
Vitamin C (as ascorbic acid) is a vitamin which is necessary for the proper functioning of living organisms. It takes part in the transformation of tyrosine and the synthesis of adrenal steroids and collagen. Its level regulates the number of lymphocytes in the bloodstream, on which the immune system function is based. Furthermore, it shows protective properties against numerous toxic substances, such us: lead, carbon disulphide, aniline and others. What is more, it shows wide antioxidant properties and is able to protects DNA, proteins and fats from oxidation. It is necessary for the proper conduction of the phagocytosis processes.
Vitamin B1 (as thiamine hydrochloride) plays an essential role in the process of the energy production during aerobic transformations which take place in the mitochondria. It participates in the metabolism of amino acids, but its the most important role is the participation in the carbohydrates transformation. In the case of a diet rich in simple sugars, the reserves of vitamin B1 may be reduced.
The tissues which require large energy expenditure (nervous system, muscles, the heart muscle, the liver) have a fairly high demand for thiamine. This is why by the deficiency of this vitamin occur the disorders of their functions. Vitamin B1 has an especially important role in the activities and the regeneration of the central nervous system. It also supports the growth process and accelerates the wound healing as well as shows pain-killing properties.
Vitamin B2 (as riboflavin and riboflavin-5′-phosphate) plays an important role in energy metabolism by an active participation in the transformation of amino acids, lipids and carbohydrates and due to the fact that it is a cofactor for many mitochondrial enzymes. It is believed that up to 4% of all known enzymes in the human body system can use riboflavin or its metabolites in the processes of energy transfer. Riboflavin is contained in two coenzymes: flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). Thanks to that it participates in the processes of oxidation and reduction.
It plays a role in the proper functioning of the nervous system, and along with vitamin A, in the normal functioning of mucous membranes, respiratory tract, gastrointestinal mucosa, blood vessels epithelium and skin. Moreover, it contributes to the proper functioning of the sight organ. There are scientific evidences which indicate that riboflavin participates in the generation of red blood cells and the blood itself.
Vitamin B3 (as niacin and nicotinamide) participates in the transformation of energy components which should release energy. It participates in the generation of red blood cells, reduces the toxic action of chemicals and medicines, regulates the cholesterol levels in the bloodstream, dilates blood vessels, positively influences the nervous system and mental condition as well as it improves blood circulation in the skin and hair condition.
Vitamin B6 (as pyridoxine hydrochloride and pyridoxal 5'-phosphate / P-5-P) improves the immunity of the body system and participates in the generation of antibodies. It helps in the transformation of tryptophan into vitamin PP, which increases the level of the vitamin B6 in the body. It is also essential for the synthesis of porphyrins (the synthesis of heme to hemoglobine in the red blood cell production) and hormones (for example: histamine, and serotonin).
The biologically active forms of vitamin B6 (coenzymes) are phosphate derivatives of pyridoxamine and pyridoxal. Enzymes with such coenzymes are involved mainly in transformation of amino acids, for instance in the racemisation of the optically active amino acids and the decarboxylation of amino acids. Pyridoxal phosphate cooperates with glycogen phosphorylase and participates in the transamination reaction.
Folic acid (as 5-methyltetrahydrofolate / 5-MTHF) participates in the formation of the nucleic acids – DNA and RNA, synthesis of amino acids and the process of cell division. It plays an important role in the process of red blood cells generation (together with vitamin B12), in the formation process of the myelin sheath of neurons and the conversion of homocysteine in methionine. Its deficiency during pregnancy may lead to the defects of neural tube and miscarriage, and in the adulthood – anemia excavatum.
Why folates instead of folic acid?
Levomefolic acid, 5-methyltetrahydrofolate (5-MTHF) is a folate – an active form of vitamin B9. Unlike folates, the folic acid can be transformed into its active form by the liver and not in the digestive system, which is less efficient and slower. The body system needs more time for the synthesis of 5-MTHF and this may disturb the general metabolism of the substance. It often results in the fact that folic acid will be deposited in the body system, which may increase the risk of particular tumours and may lead to latent deficiency of vitamin B12.
Vitamin B12 (as methylcobalamin) is required for the proper functioning of the nervous system and the gastrointestinal tract. The deficits of vitamin B12 can cause inhibition of growth and reproduction of cells (including red blood cells – erythrocytes), as well as degenerative changes of the spinal cord and the peripheral nerves in the central nervous system. The vitamin B12 deficiency leads also to megaloblastic anaemia.
Methylcobalamin is the most effective, best absorbable and biologically active form of vitamin B12. It is the only one to cross the blood-brain barrier and thanks to that it has an influence on the functioning of the central nervous system. Thanks to methyl groups, it stimulates the production of particular neurotransmitters. Moreover, it is of great importance in the process of growth and cell replication.
Among some people, the liver cannot convert cyanocobalamin, a common supplementary form of vitamin B12, into appropriate amount of methylcobalamin, which is essential for the proper functioning of neurons or to direct protection of brain cells from dangerous toxins.
Methylcobalamin achieves its neuroprotective effect by increasing methylation, accelerating the growth of nerve cells or the ability to neutralize the high homocysteine levels, which is responsible for the cardiovascular system diseases, atherosclerotic and thrombotic lesion, heart attack or stroke.
Biotin is built into the molecular structure of several enzymes (which are called carboxylases) which are the enzymes required in numerous important biochemical reactions, for instance in the process of glucose generation (gluconeogenesis), fatty acid synthesis, metabolism of branched amino acids or the citric acid cycle.
Biotin is also a vitamin which helps in the regulation of DNA structures and stabilisation of gene activity, and this mainly thanks to binding with proteins which are closely related to DNA. The researchers have identified more than 2,000 human genes which are dependent on biotin.
Pantothenic acid (as calcium pantothenate) is a component of coenzyme A as well as of the multienzyme complex which catalyses the synthesis of fatty acids. It participates in the synthesis of heme into hemoglobine and cytochromes. It takes part in the regeneration of skin cells and mucous membranes, participates in the generation of antibodies and supports the process of hair pigmentation.
To sum it all up, Doctor's Best Best B Complex is an excellent product which provides a wide range of B vitamins and vitamin C. It is recommended for people who are exposed to vitamin deficiencies which result from the disorders of nutrient absorption by the intestines and irregularities in the composition of the intestinal flora of the digestive system.
People who use elimination or one-component diets and elderly people are especially exposed to the deficits of B vitamins. The product may be very helpful in the supplementation of physically active people and athletes, who are exposed to loss of water-soluble vitamins as they are excreted with sweat.
A complete set of vitamins B. Their deficiencies are so common that it's worth permanently incorporating this into your supplementation. 1 capsule per day should be enough. But keep in mind that the demand for B vitamins increases when the body uses more energy. Hence athletes or physically hard working people may increase the dose to 2 capsules a day without any fears. Few people know that behind popular ailments, such as"radiculitis" are often shortages of vitamins B. Therefore, if we have a problem with recurrent ailment, the best thing to do is start regularly taking vitamins from group B.
Physician-founded in 1990, Doctor’s Best is a science-based nutritional supplement company, offering more than 200 products, made primarily with branded ingredients that are thoroughly researched, manufactured to the highest quality standards, and rigorously tested every step of the way—from raw materials to finished product. We use only cGMP-certified manufacturing facilities. Doctor’s Best is committed to transparency through education and communication and strives to be crystal clear in what we offer, why and how we offer it.
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|per 1 capsule||amount||%DV|
|Vitamin C (as ascorbic acid)||40 mg||45%|
|Vitamin B1 (from thiamin HCl)||60 mg||5000%|
|Vitamin B2 (from riboflavin and riboflavin-5-phosphate)||75 mg||5770%|
|Vitamin B3 (as niacinamide and niacin)||50 mg||310%|
|Vitamin B6 (from pyridoxine hydrochloride and pyridoxal-5-phosphate)||50 mg||2940%|
|Folate (from Quatrefolic®, (6S)-5-methyltetrahydrofolic acid, glucosamine salt)||400 mcg||100%|
|Vitamin B12 (as methylcobalamin)||1000 mcg||41670%|
|Pantothenic acid (from d-calcium pantothenate)||100 mg||2000%|
Modified cellulose (vegetarian capsule), magnesium stearate (vegetable source), microcrystalline cellulose, silicon dioxide, ascorbyl palmitate.
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