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HomocysteX HomocysteX

Seeking Health HomocysteX is a modern formula which supports normal methylation processes and helps maintain healthy homocysteine levels in the body. The supplement contains synergistic B vitamins (B2, B6, B9, B12) in biologically active forms and carefully selected doses.

It is recommended to persons who struggle with methylation disorders and elevated homocysteine levels due to an improper diet, chronic inflammation, increased oxidative stress or MTHFR polymorphism.

Homocysteine modulators
This supplement contains key compounds which ensure effective methylation and thus aid in maintaining normal homocysteine levels. These are so-called homocysteine modulators. This group includes:
Vitamin B2 (riboflavin) belongs to water-soluble compounds and is formed from ribitol and flavin. It functions as a precursor for two vital coenzymes which are FMN (flavin mononucleotide) and FAD (flavin adenine dinucleotide). FAD is a cofactor for methylenetetrahydrofolate reductase and that is why riboflavin will lower homocysteine levels in persons who are homozygous for 677C->T mutation. In addition, it has been confirmed in studies that persons respond well to vitamin B2 administration for lowering blood pressure. Scientists have demonstrated that low vitamin B2 levels may impair methylation reactions in the brain which results in symptoms similar to those of classic depression.

Vitamin B6 is a complex of six pyridine derivatives. They are all converted in the body into pyridoxal 5′-phosphate, the most biologically active form of vitamin B6. Its basic role is to metabolise proteins and transfer amino acid and sulphur groups. Even though it is not involved directly in methylation, it acts as a cofactor of an enzyme that is critical to the conversion of homocysteine into cysteine. Without enough vitamin B6, remethylation is not effective, which may lead the accumulation of homocysteine that is dangerous to your health.

Vitamin B9 (folic acid) is the most important regulator of homocysteine levels. It provides methyl groups which facilitate the conversion of homocysteine into the harmless methionine. However, it must be converted at first effectively in the body into its active form, namely 5-methyltetrahydrofolate. This process is controlled by the enzyme methylene tetrahydrofolate reductase (MTHFR).

Individuals with a MTHFR gene mutation must remember that supplementation with the inactive folic acid will cause dangerous accumulation of this compound. The body will suffer from the deficiency of the folate required for normal homocysteine metabolism. When choosing a product for you, it is worth checking if it contains an active, methylated form of folic acid.

Vitamin B12 (cobalamin) is essential for the proper course of two key enzymatic reactions: methionine synthesis and isomerisation of methylmalonyl-CoA to succinyl-CoA. What is more, it converts some forms of tetrahydrofolic acid into its active form, which is 5-MTHF.

If vitamin B12 is to effectively support the methylation process, it should be provided as the active methylcobalamine. When it is supplemented as cyanocobalamin, it may not perform its function.

Problems with homocysteine
Homocysteine is a by-product of methylation. It is formed during the metabolism of the amino acid methionine. It is utilised by two ways – it is either converted into methionine during remethylation or cysteine in sulphurisation. If methylation is not effective or one of metabolic processes fails, hyperhomocysteinemia occurs.

Elevated homocysteine levels increase the tendency for accumulation of atherosclerotic plaques in the arteries, promote hypertension and increase the risk of cardiovascular diseases.

Importance of methylation
Methylation is a complicated process during which a hydrogen atom is replaced by a methyl group (composed of a carbon atom and three hydrogen atoms) that binds to a specific enzyme. Owing to that, cell division, repair of damaged DNA structures and detoxification of the body are possible. What is more, methylation provides the body with methyl groups which are involved in the synthesis of such compounds as choline, carnitine and coenzyme Q10 and production of the most important neurotransmitters – serotonin and dopamine.

Methylation processes are impaired most frequently due to too few methyl groups and deficiency in ingredients which are critical to normal course of methylation (mainly vitamin B6, B12 and folic acid). The gene defect, namely a MTHFR polymorphism, is more and more common. Individuals with this mutation do not convert folic acid into its active form.

Methylation disorders are suggested as one of the main causes of cardiovascular diseases. It may be also the cause of problems with getting pregnant, increase the likelihood of neurodegenerative diseases and lead to the impairment of cognitive abilities.

To sum up, Seeking Health HomocysteX is a supplement which provides B vitamins in forms which are bioavaiable for the body and have a real impact on the course of methylation and normal homocysteine metabolism.  The formula works perfectly as cardiovascular prevention and for persons with a MTHFR gene mutation.

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Since 2005
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HomocysteX HomocysteX 60 caps.
Seeking Health
27.49 $

HomocysteX 60 caps.

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- Delivery even day after tomorrow

- Foreign shippment from 5.69 $ Every 83.30 $ reduces shipping costs by 2.78 $

You have got questions about the product

sales@mz-store.co.uk

01709231594 (mon.-fri 900-1700)

Description
  • Blend of homocysteine modulators
  • Promotes normal methylation processes
  • Cardiovascular prevention
  • Contains bioactive forms of B vitamins
  • Recommended to individuals with MTHFR gene mutation
  • Helps regulate homocysteine levels
  • Supports cognitive health

Seeking Health HomocysteX is a modern formula which supports normal methylation processes and helps maintain healthy homocysteine levels in the body. The supplement contains synergistic B vitamins (B2, B6, B9, B12) in biologically active forms and carefully selected doses.

It is recommended to persons who struggle with methylation disorders and elevated homocysteine levels due to an improper diet, chronic inflammation, increased oxidative stress or MTHFR polymorphism.

Homocysteine modulators
This supplement contains key compounds which ensure effective methylation and thus aid in maintaining normal homocysteine levels. These are so-called homocysteine modulators. This group includes:
Vitamin B2 (riboflavin) belongs to water-soluble compounds and is formed from ribitol and flavin. It functions as a precursor for two vital coenzymes which are FMN (flavin mononucleotide) and FAD (flavin adenine dinucleotide). FAD is a cofactor for methylenetetrahydrofolate reductase and that is why riboflavin will lower homocysteine levels in persons who are homozygous for 677C->T mutation. In addition, it has been confirmed in studies that persons respond well to vitamin B2 administration for lowering blood pressure. Scientists have demonstrated that low vitamin B2 levels may impair methylation reactions in the brain which results in symptoms similar to those of classic depression.

Vitamin B6 is a complex of six pyridine derivatives. They are all converted in the body into pyridoxal 5′-phosphate, the most biologically active form of vitamin B6. Its basic role is to metabolise proteins and transfer amino acid and sulphur groups. Even though it is not involved directly in methylation, it acts as a cofactor of an enzyme that is critical to the conversion of homocysteine into cysteine. Without enough vitamin B6, remethylation is not effective, which may lead the accumulation of homocysteine that is dangerous to your health.

Vitamin B9 (folic acid) is the most important regulator of homocysteine levels. It provides methyl groups which facilitate the conversion of homocysteine into the harmless methionine. However, it must be converted at first effectively in the body into its active form, namely 5-methyltetrahydrofolate. This process is controlled by the enzyme methylene tetrahydrofolate reductase (MTHFR).

Individuals with a MTHFR gene mutation must remember that supplementation with the inactive folic acid will cause dangerous accumulation of this compound. The body will suffer from the deficiency of the folate required for normal homocysteine metabolism. When choosing a product for you, it is worth checking if it contains an active, methylated form of folic acid.

Vitamin B12 (cobalamin) is essential for the proper course of two key enzymatic reactions: methionine synthesis and isomerisation of methylmalonyl-CoA to succinyl-CoA. What is more, it converts some forms of tetrahydrofolic acid into its active form, which is 5-MTHF.

If vitamin B12 is to effectively support the methylation process, it should be provided as the active methylcobalamine. When it is supplemented as cyanocobalamin, it may not perform its function.

Problems with homocysteine
Homocysteine is a by-product of methylation. It is formed during the metabolism of the amino acid methionine. It is utilised by two ways – it is either converted into methionine during remethylation or cysteine in sulphurisation. If methylation is not effective or one of metabolic processes fails, hyperhomocysteinemia occurs.

Elevated homocysteine levels increase the tendency for accumulation of atherosclerotic plaques in the arteries, promote hypertension and increase the risk of cardiovascular diseases.

Importance of methylation
Methylation is a complicated process during which a hydrogen atom is replaced by a methyl group (composed of a carbon atom and three hydrogen atoms) that binds to a specific enzyme. Owing to that, cell division, repair of damaged DNA structures and detoxification of the body are possible. What is more, methylation provides the body with methyl groups which are involved in the synthesis of such compounds as choline, carnitine and coenzyme Q10 and production of the most important neurotransmitters – serotonin and dopamine.

Methylation processes are impaired most frequently due to too few methyl groups and deficiency in ingredients which are critical to normal course of methylation (mainly vitamin B6, B12 and folic acid). The gene defect, namely a MTHFR polymorphism, is more and more common. Individuals with this mutation do not convert folic acid into its active form.

Methylation disorders are suggested as one of the main causes of cardiovascular diseases. It may be also the cause of problems with getting pregnant, increase the likelihood of neurodegenerative diseases and lead to the impairment of cognitive abilities.

To sum up, Seeking Health HomocysteX is a supplement which provides B vitamins in forms which are bioavaiable for the body and have a real impact on the course of methylation and normal homocysteine metabolism.  The formula works perfectly as cardiovascular prevention and for persons with a MTHFR gene mutation.

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Composition

Composition

Container size: 60 capsulesServing size: 1 capsuleServings per container: 60
per 1 portion (1 capsule)amount%DV
Riboflavin (as riboflavin-5’-phosphate sodium)25 mg1923%
Vitamin B6 (as pyridoxal-5’-phosphate)25 mg1471%
Folate (as Quatrefolic (6S)-5-methyltetrahydrofolate, glucosamine salt)800 mcg 200%
Vitamin B12 (80% as methylcobalamin and 20% as adenosylcobalamin)1000 mcg 41667%

Other ingrednients

Microcrystalline cellulose, HPMC (capsule), ascorbyl palmitate, L-leucine, and silica.

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Sodium

Information

Sodium is an important component of the intracellular fluids, and is a regulator of acid-base balance. Along with potassium affects the proper of growth and provides the proper functioning of muscles and nerves. The source of acquisition is table salt (NaCl) and bladderwrack, shellfish, bacon, beef, and of plant beets and carrots. People on salt-free diet should avoid, among others, spicy sauces and smoked meats and sausages.
Sodium deficiency is very rare, at heaving sweating after a long effort (e.g. in the marathon).
Excess sodium increases blood pressure (especially for the elderly), edema and increased thirst. Exceeding the daily dose of 14g a day can cause poisoning.


 

Vitamin B6

Information

Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) is soluble in the liquid. It participates in the metabolism of proteins, fats and carbohydrates. By reducing the amount of fat in the blood do not enable deposition of the body. It helps the absorption of magnesium and vitamin B12 (cobalamin). It works on the muscle antispasmodic and anti-inflammatory pain in the joints. It acts anti. It provides efficient operation of the brain. It increases energy increasing vigor of a man. The demand for vitamin B6 increases during pregnancy and breast-feeding infants. The natural product is: yeast, eggs, wheat germ, meat (liver), wheat bran, nuts, peanuts peanuts, soybeans. There is a hypothesis that can be synthesized by intestinal bacteria.
Deficiency of vitamin B6 causes abnormal metabolism of proteins, decrease in lymphocytes in the blood, causes a feeling of lethargy and fatigue intensifies.
Dosage: 1.5-2.5 mg daily (increased demand during pregnancy and lactation).


 

Quatrefolic

Information

Quatrefolic is the glucosamine salt of (6S)-5-methyltetrahydrofolate and also an active form of folic acid. It is an innovative nutrient (fourth generation folate) which is well soluble in water and thus absorbed effectively by the body. As an organic compound ranked among B vitamins, it is necessary for normal functioning at the cellular level.

Adding folates to a diet is recommended especially to pregnant and lactating women. These compounds may contribute to healthy foetal development. According to studies, their intake may reduce the incidence of pregnancy complications.

Some sources report that folate supplementation supports cardiovascular function (blood production) and contribute to healthy immune function.

Quatrefolic may affect the metabolism of homocysteine whose levels increase in the body over time. Adding it to a diet may thus prevent the development of dementia and maintain healthy cognitive functions which is vital to adults, especially the elderly.

Salt

Information

Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl

Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).

 

Methylcobalamin

Information

What is methylcobalamin?

Methylcobalamin is a biologically active form of vitamin B12. It is one of the two forms of this vitamin that may be used as cofactors in various reactions. It differs from popular cyanocobalamin in the presence of methyl group instead of cyanide, thanks to which it releases the organism from the need of neutralizing this harmful factor.

The methyl group from methylcobalamin may be transferred to homocysteine, thanks to which it comes back in the form of methionine in order to be further converted to SAMe, which is the main donor of methyl groups in our organism. These methyl groups may be then used in the processes of creatine production, in neurotransmitter metabolism and as DNA methylation, thanks to which we achieve proper energy level, better well-being and generally better condition of the organism. B12 is a coenzyme for three enzymes: isomerase, methyltransferase and dehalogenase.

Apart from the influence on the nervous system, the supply of vitamin B12 is also very important for the proper synthesis of red cells as well as hemoglobin and anemia prevention.

 

Methylcobalamin in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.

Adenosylcobalamin

Information

Adenosylcobalamin - a biologically active form of vitamin B12, which similarly to its methylated form does not need to undergo additional biochemical transformations in order to enter metabolic pathways in the human organism.

Apart from the best assimilability, adenosylcobalamin is distinguished from other forms of vitamin B12 by its high affinity for regeneration of nervous tissue. It is indicated that this form of cobalamin is engaged in the production of myelin sheaths with key meaning for proper neurotransmission. Apart from this, vitamin B12 is conducive to maintaining optimal functionality of the nervous system, being conducive to the synthesis of neurotransmitters.

Vitamin B12 is also an incredibly important regulator of methylation process, thanks to which its supplementation positively influences metabolism of the whole organism. It is a coenzyme in the conversion reactions of homocysteine to methionine as well as methylmalonyl-CoA to succinyl-CoA. Because of the first reaction, proper supply of vitamin B12 is also conducive to maintaining high concentrations of S-adenosylmethionine, thanks to which it positively influences mental functions.

Moreover, vitamin B12 is a key regulatory factor, taking part in erythropoiesis, i.e. the process of forming red cells. Its improper supply may be the cause of the development of the so-called vitamin B12 deficiency anemia.

Supplementation with vitamin B12 should be considered especially be people on vegetable diets and those who take drugs from the group of proton-pump inhibitors (PPIs) and metformin.

 

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