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Doctor's Best, Best Vitamin D3 is a dietary supplement of multi-directional activity which contains vitamin D3. The product is the perfect complement to your daily diet. It helps to keep your bones strong and healthy, supports functioning of the immune system, protects the nervous system and shows anticancer properties.
The product is recommended mainly in the autumn-winter period, during which the synthesis of vitamin D in the skin declines. The supplement is also recommended for people who avoid sun exposure. Moreover, the preparation is recommended for people who are exposed to increased risk of diseases of affluence and disorders in bone mineral balance.
Vitamin D3 (cholecalciferol) plays a core role in numerous processes in the body system. This vitamin i.a. participates in the process of calcium absorption in the small intestine, secretion of particular hormones and is also responsible for the proper functioning of the nervous system and the immune system as well as shows antimutagenic properties.
Vitamin D can be produced endogenously by converting 7-dehydrocholesterol (which is present in skin) into cholecalciferol in the presence of UVB radiation. How much vitamin D3 will be synthesized in your skin depends from i.a. age, latitude, the degree of air pollution, the content of melanin in your skin, the body surface area which is exposed to sun as well as whether we use cosmetics with UV filter.
The consequences of vitamin D3 deficiency
Unfortunately, the deficiency of vitamin D3 is already considered to be an epidemiological problem. Avitaminosis D3 contributes to rickets, osteomalacia, myopathy, parathyroid glands hyperactivity as well as autoimmune diseases and cancers. Vitamin D3 deficiency may be associated with obesity, kidney and liver function disorders and impaired absorption of fats from the intestinal tract.
The role of vitamin D3 in neurological disorders
More and more research indicates a close relationship between vitamin D3, and actually its deficiencies, and the occurrence of diseases of the central nervous system (i.a. Alzheimer's disease, depression, schizophrenia, epilepsy). Vitamin D shows neuroprotective properties and contributes to the reduction of calcium ions in the brain, which at the same time reduces the expression of type I calcium channels, which are responsible for the damage to the brain tissue.
Moreover, there is more and more evidence saying that vitamin D3 can be one of the factors responsible for the occurrence of multiple sclerosis (MS), which is a chronic inflammatory disease of the central nervous system, which results in the damage of the myelin sheaths surrounding nerve fibers. In scientific studies it has been demonstrated that the incidence of the disease increases in the regions with less sunlight, which has been linked to a lower synthesis of vitamin D3 in skin.
Anticancer properties of vitamin D3
Vitamin D3 reduces proliferation and increases the differentiation in tumor cells of leukemia lines M1 and HL-60. A similar effect can be also observed in the case of cancers of prostate, breast, colon or melanoma. Moreover, it has been proven that vitamin D3 limits the invasiveness of tumors, as it reduces the activity of metaloproteases and serine proteases, and also increases the expression of the cadherin E. The researchers have so far examined many different mechanisms of action of vitamin D contributing to its anticancer activity, which creates hope for a lower risk of cancer and improved effectiveness of cancer therapy.
The influence of vitamin D3 on the calcium-phosphate metabolism
Vitamin D3 contributes to an increase in the levels of calcium and phosphates in serum by stimulating intestinal absorption. The vitamin has a positive influence on the proper bone mineralization and supports the process of bone remodeling. It has been observed that in the autumn-winter period, in which sun exposure and skin synthesis of vitamin D3 is much reduced, there is a deterioration of bone tissue condition.
To sum it all up, Doctor's Best, Best Vitamin D3 is a dietary supplement recommended for everyone. Due to the fact that deficiencies of vitamin D3 are common around the world as well as that people are exposed to diseases caused by insufficient supply of this vitamin, it is worth to take care of its supplementation. The product effectively increases the level of vitamin D3 in the body system, it is an essential measure within the prevention of rickets and osteomalacia as well as it can also have therapeutic effects in numerous diseases.
The lowest effective daily dose of vitamin D is 1000-2000 IU, while the recommended therapeutic doses in the case of adults and elderly people are 7000-10000 IU of vitamin D per day, which is important especially in the fall-winter season, when the skin synthesis is considerably limited.
Because of the fact that vitamin D is a compound soluble in fats, in order to ensure its best absorption, it should be taken with a meal containing fat.
It is worth to combine vitamin D3 with vitamin K2. It supports calcium absorption in bones and prevents too high level of calcium in blood.
Physician-founded in 1990, Doctor’s Best is a science-based nutritional supplement company, offering more than 200 products, made primarily with branded ingredients that are thoroughly researched, manufactured to the highest quality standards, and rigorously tested every step of the way—from raw materials to finished product. We use only cGMP-certified manufacturing facilities. Doctor’s Best is committed to transparency through education and communication and strives to be crystal clear in what we offer, why and how we offer it.
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|per 1 softgel||amount||%DV|
|Vitamin D3 (as Cholecalicferol)||5000 IU||625%|
Extra virgin olive oil, softgel capsule (gelatin, glycerin, purified water).
Vitamin D belongs to fat soluble vitamins, occurs in three forms: calciferol (vitamin D1) ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), it is formed under the action of sunlight for at least 15 minutes per day. In the absence of sunlight it should be administered in the diet in the form of fish oil (Vitamin A + D3) and fish oils. It is responsible for the absorption of calcium and phosphorus. It is the building substance of bone tissue particularly necessary during pregnancy, childhood, and for athletes. It is a component of dietary supplements and nutrients among competetive athletes. Deficiency of vitamin D causes children growth inhibition, and rickets.
For adults - deficiency causes osteomalacia.
Excess of vitamin D causes headaches, alopecia, nausea, drowsiness, blurred vision, pain in the long bones, the deposition of calcium deposits.
Dosage: 400 IU units during the day.
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